Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Brendan Grau"'
Autor:
Eric R. Ashley, Gregory L. Beutner, Brendan Grau, Amude M. Kassim, Matthew D. Truppo, Jingjun Yin, John Limanto, Hallena R. Strotman, Zhijian Liu, Mary M. Kim, Artis Klapars
Publikováno v:
Organic Letters. 16:2716-2719
A novel synthesis of vernakalant is described. Using inexpensive and readily available reagents, the key transformations involve (1) an efficient zinc-amine-promoted etherification, (2) a highly stereoselective enzyme-catalyzed dynamic asymmetric tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cfe972d367530c2775b8385cb90fd9
https://doi.org/10.1021/ol501002a
https://doi.org/10.1021/ol501002a
Publikováno v:
Organic letters. 9(24)
Chiral fluorinated hydroxyketones were synthesized with excellent ee (>98%) and yield by a chemo- and stereoselective reduction of prochiral methyl/trifluoromethyl diketones using commercially available ketoreductase enzymes. By using p- and m-triflu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fa9fdccf5c5b618e111b169dea3597
https://pubmed.ncbi.nlm.nih.gov/17973397
https://pubmed.ncbi.nlm.nih.gov/17973397
Autor:
Krista Morley, Jacob M. Janey, Ian W. Davies, Greg Hughes, Scott J. Pollack, Brendan Grau, Matthew D. Truppo
Publikováno v:
Catalysis Science & Technology. 2:1556
The use of transaminases for the incorporation of deuterium and tritium in chiral amines starting from prochiral ketone precursors has been demonstrated. Efficient labeling was demonstrated using a variety of ketone substrates. Amplification of the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c76491bca85f3b2d9d0e001bca79786d
https://doi.org/10.1039/c2cy20110k
https://doi.org/10.1039/c2cy20110k
Publikováno v:
The Journal of Organic Chemistry. 66:6836-6837
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c6903b203291fea0a2418c5bedfdeb
https://doi.org/10.1021/jo015966n
https://doi.org/10.1021/jo015966n