Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Brendan F, Kohrn"'
Autor:
David W. Woolston, Nathan D. Lee, Mazyar Shadman, Elena Latorre-Esteves, Xin Ray Tee, Jeanne Fredrickson, Brendan F. Kohrn, Chaitra Ujjani, Ashley Eckel, Brian Till, Min Fang, Jerald Radich, Ivana Bozic, Rosa Ana Risques, Cecilia C.S. Yeung
Publikováno v:
Haematologica, Vol 109, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/542a298ed0e44e0db8002b7784b77e69
Autor:
David W. Woolston, Nathan D. Lee, Mazyar Shadman, Elena Latorre-Esteves, Xin Ray Tee, Jeanne Fredrickson, Brendan F. Kohrn, Chaitra Ujjani, Ashley Eckel, Brian Till, Min Fang, Jerald Radich, Ivana Bozic, Rosa Ana Risques, Cecilia C.S. Yeung
Publikováno v:
Haematologica, Vol 109, Iss 3 (2023)
BTK inhibitors, Bcl-2 inhibitors, and other targeted therapies have significantly improved the outcomes of patients with chronic lymphocytic leukemia (CLL). With increased survivorship, monitoring disease and deciphering potential mechanisms of resis
Externí odkaz:
https://doaj.org/article/0f5b94b207804bfbba3755740dba5865
Autor:
Yinuo Li, Xiuhua Xu, Huma Asif, Yue Feng, Brendan F. Kohrn, Scott R. Kennedy, J. Julie Kim, Jian-Jun Wei
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-17 (2022)
Highlights High rate of MED12 mutations and leiomyoma burden are clearly associated with myometrial oxidative stress. MED12 mutations are driven by misrepair of 8-OHdG at c.130-c.131 detected by deep sequencing analysis both in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/fa4d73ee827a428fb574c9eddc9efbec
Autor:
Talayeh S. Ghezelayagh, Brendan F. Kohrn, Jeanne Fredrickson, Enna Manhardt, Marc R. Radke, Ronit Katz, Heidi J. Gray, Renata R. Urban, Kathryn P. Pennington, John B. Liao, Kemi M. Doll, Elise J. Simons, Jennifer K. Burzawa, Barbara A. Goff, Paul Speiser, Elizabeth M. Swisher, Barbara M. Norquist, Rosa Ana Risques
Publikováno v:
Cancer Research Communications. 2:1282-1292
Current screening methods for ovarian cancer have failed to demonstrate a significant reduction in mortality. Uterine lavage combined with TP53 ultradeep sequencing for the detection of disseminated ovarian cancer cells has emerged as a promising too
Autor:
Talayeh S, Ghezelayagh, Brendan F, Kohrn, Jeanne, Fredrickson, Enna, Manhardt, Marc R, Radke, Ronit, Katz, Heidi J, Gray, Renata R, Urban, Kathryn P, Pennington, John B, Liao, Kemi M, Doll, Elise J, Simons, Jennifer K, Burzawa, Barbara A, Goff, Paul, Speiser, Elizabeth M, Swisher, Barbara M, Norquist, Rosa Ana, Risques
Publikováno v:
Cancer Res Commun
Current screening methods for ovarian cancer (OC) have failed to demonstrate a significant reduction in mortality. Uterine lavage combined with TP53 ultra-deep sequencing for the detection of disseminated OC cells has emerged as a promising tool, but
Autor:
Rosa Ana Risques, Barbara M. Norquist, Elizabeth M. Swisher, Paul Speiser, Barbara A. Goff, Jennifer K. Burzawa, Elise J. Simons, Kemi M. Doll, John B. Liao, Kathryn P. Pennington, Renata R. Urban, Heidi J. Gray, Ronit Katz, Marc R. Radke, Enna Manhardt, Jeanne Fredrickson, Brendan F. Kohrn, Talayeh S. Ghezelayagh
Current screening methods for ovarian cancer have failed to demonstrate a significant reduction in mortality. Uterine lavage combined with TP53 ultradeep sequencing for the detection of disseminated ovarian cancer cells has emerged as a promising too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935b8042855ea29e7c605d33eb84f855
https://doi.org/10.1158/2767-9764.c.6550803
https://doi.org/10.1158/2767-9764.c.6550803
Autor:
Rosa Ana Risques, Barbara M. Norquist, Elizabeth M. Swisher, Paul Speiser, Barbara A. Goff, Jennifer K. Burzawa, Elise J. Simons, Kemi M. Doll, John B. Liao, Kathryn P. Pennington, Renata R. Urban, Heidi J. Gray, Ronit Katz, Marc R. Radke, Enna Manhardt, Jeanne Fredrickson, Brendan F. Kohrn, Talayeh S. Ghezelayagh
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779d5debab4067df26859628fcf93f10
https://doi.org/10.1158/2767-9764.22544940
https://doi.org/10.1158/2767-9764.22544940
Autor:
Rosa Ana Risques, Barbara M. Norquist, Elizabeth M. Swisher, Paul Speiser, Barbara A. Goff, Jennifer K. Burzawa, Elise J. Simons, Kemi M. Doll, John B. Liao, Kathryn P. Pennington, Renata R. Urban, Heidi J. Gray, Ronit Katz, Marc R. Radke, Enna Manhardt, Jeanne Fredrickson, Brendan F. Kohrn, Talayeh S. Ghezelayagh
Table S1. Clinical patient informationTable S2. Duplex Sequencing gene targetsTable S3. Custom probes for hotspotsTable S4. Mutation Frequency and Mutation Burden by patient and geneTable S5. Codons most frequently mutated in ovarian cancersTable S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74307ae151fd8adb045ea362a8686575
https://doi.org/10.1158/2767-9764.22544937
https://doi.org/10.1158/2767-9764.22544937
Autor:
Rosa Ana Risques, Barbara M. Norquist, Elizabeth M. Swisher, Paul Speiser, Barbara A. Goff, Jennifer K. Burzawa, Elise J. Simons, Kemi M. Doll, John B. Liao, Kathryn P. Pennington, Renata R. Urban, Heidi J. Gray, Ronit Katz, Marc R. Radke, Enna Manhardt, Jeanne Fredrickson, Brendan F. Kohrn, Talayeh S. Ghezelayagh
S1. Experimental designS2. Association between the variant allele frequency (VAF) of tumor mutations identified in uterine lavage with stage of the ovarian cancer (A) and preoperative CA-125 level (B)S3. Gene distribution of the largest mutant clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846abd237654468ab3ecaaf6e86d4136
https://doi.org/10.1158/2767-9764.22544943
https://doi.org/10.1158/2767-9764.22544943
Autor:
Monica Sanchez-Contreras, Mariya T. Sweetwyne, Kristine A. Tsantilas, Jeremy A. Whitson, Matthew D. Campbell, Brendan F. Kohrn, Hyeon Jeong Kim, Micheal J. Hipp, Jeanne Fredrickson, Megan M. Nguyen, James B. Hurley, David J. Marcinek, Peter S. Rabinovitch, Scott R. Kennedy
Accumulation of somatic mutations in the mitochondrial genome (mtDNA) during aging has long been proposed as a possible mechanism of mitochondrial and tissue dysfunction. A thorough characterization of age-associated mtDNA somatic mutations has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::096eaf33a6859cf4e3c0a95c2a4b66d6
https://doi.org/10.1101/2022.08.30.505884
https://doi.org/10.1101/2022.08.30.505884