Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Brendan F, Boyce"'
Autor:
Zhenqiang Yao, Akram Ayoub, Venkatesan Srinivasan, Jun Wu, Churou Tang, Rong Duan, Aleksa Milosavljevic, Lianping Xing, Frank H. Ebetino, Alison J. Frontier, Brendan F. Boyce
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone formation, while the anabolic agent, teriparatide, does not inhibit bone resorption, and thus they have limited efficacy in
Externí odkaz:
https://doaj.org/article/9342ddf34d9e437d96b8b870a032df6e
Publikováno v:
Endocrinology and Metabolism, Vol 38, Iss 5, Pp 504-521 (2023)
Maintenance of skeletal integrity requires the coordinated activity of multinucleated bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoclasts form resorption lacunae on bone surfaces in response to cytokines by fusion of precursor cells.
Externí odkaz:
https://doaj.org/article/0e3c90b5a9b44848850a9ae54c1c912c
Autor:
Jinbo Li, Zhenqiang Yao, Xin Liu, Rong Duan, Xiangjiao Yi, Akram Ayoub, James O. Sanders, Addisu Mesfin, Lianping Xing, Brendan F. Boyce
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Age-related osteoporosis is known to be dependent on TGFβ1 signalling. Here the authors show that a subset of neutrophils (identified by TGFβ1+CCR5+) increase during aging in mouse bone marrow resulting in bone loss, while a CCR5 antagonist can red
Externí odkaz:
https://doaj.org/article/caabbfc0732a40c8a46c9011575cb27a
Autor:
Qianze Dong, Yan Xiu, Yang Wang, Christina Hodgson, Nick Borcherding, Craig Jordan, Jane Buchanan, Eric Taylor, Brett Wagner, Mariah Leidinger, Carol Holman, Dennis J. Thiele, Sean O’Brien, Hai-hui Xue, Jinming Zhao, Qingchang Li, Howard Meyerson, Brendan F. Boyce, Chen Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Acute myeloid leukaemia (AML) is maintained by self-renewing leukemic stem cells. Here the authors show that Heat Shock Transcription Factor 1 (HSF1) is specifically required for the maintenance of AML stem cells, while sparing steady-state and stres
Externí odkaz:
https://doaj.org/article/5f343dbfc38c484a8f207124fe46c553
Autor:
Jiatong Liu, Xi Lin, Andrew McDavid, Yutiancheng Yang, Hengwei Zhang, Brendan F. Boyce, Lianping Xing
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Cellular senescence plays important roles in age-related diseases, including musculoskeletal disorders. Senescent cells (SCs) exert a senescence-associated secretory phenotype (SASP) by producing SASP factors, some of which overlap with factors produ
Externí odkaz:
https://doaj.org/article/f3556008dc5045ad96badff1926c5b72
Autor:
Calvin L. Cole, John F. Bachman, Jian Ye, Joseph Murphy, Scott A. Gerber, Christopher A. Beck, Brendan F. Boyce, Gowrishankar Muthukrishnan, Joe V. Chakkalakal, Edward M. Schwarz, David Linehan
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 731-745 (2021)
Abstract Background Skeletal muscle wasting (SMW) in cancer patients is associated with increased morbidity, mortality, treatment intolerance and discontinuation, and poor quality of life. This is particularly true for patients with pancreatic ductal
Externí odkaz:
https://doaj.org/article/253d934b0fa14eca9e41eee1ebbe2db1
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Cellular senescence plays an important role in human diseases, including osteoporosis and osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory phenotype to affect the function of neighboring cells and SCs themselves. Dela
Externí odkaz:
https://doaj.org/article/ee5217b7a6cf42768015cc8f098d936d
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
The ubiquitin/proteasome system controls the stability of Runx2 and JunB, proteins essential for differentiation of mesenchymal progenitor/stem cells (MPCs) to osteoblasts. Local administration of proteasome inhibitor enhances bone fracture healing b
Externí odkaz:
https://doaj.org/article/9cee414f2e6b4f359a2ca4a84504837c
Autor:
Jinming Zhao, Yan Xiu, Lin Fu, Qianze Dong, Nicholas Borcherding, Yang Wang, Qingchang Li, Nilushi S. De Silva, Ulf Klein, Brendan F. Boyce, Chen Zhao
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103425- (2021)
Summary: We previously showed stabilization of NIK−induced activation of NF-κB non-canonical signaling suppresses MLL-AF9−induced AML. In the current study, we demonstrate that deletion of NF-κB non-canonical RelB prevents the inhibitory effect
Externí odkaz:
https://doaj.org/article/9c0b3adda5714869b9b0e2d2d9728712
Autor:
Jinbo Li, Akram Ayoub, Yan Xiu, Xiaoxiang Yin, James O. Sanders, Addisu Mesfin, Lianping Xing, Zhenqiang Yao, Brendan F. Boyce
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor
Externí odkaz:
https://doaj.org/article/5b2df4499d844e86910a28da5979f452