Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

Autor: Irene Hernando-Herraez, Brendan Evano, Thomas Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen Clark, Simon Andrews, Shahragim Tajbakhsh, Wolf Reik

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Age-related tissue alterations have been associated with a decline in stem cell number and function. Here the authors report a single cell multi-omics study of mouse muscle stem cells, combining single cell transcriptome and DNA methylome profiling a

Externí odkaz: https://doaj.org/article/7fb038d80fdb4c259027e99923ca8c58

Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches

Autor: Brendan Evano, Sara Khalilian, Gilles Le Carrou, Geneviève Almouzni, Shahragim Tajbakhsh

Publikováno v: Cell Reports, Vol 30, Iss 10, Pp 3195-3206.e7 (2020)

Summary: Stem cells can be maintained through symmetric cell divisions (SCDs) and asymmetric cell divisions (ACDs). How and when these divisions occur in vivo in vertebrates is poorly understood. Here, we developed a clonogenic cell tracing method th

Externí odkaz: https://doaj.org/article/accc97448f4f4c68b92cd27bcbc378fc

Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures

Autor: Daniela Di Girolamo, Maria Benavente-Diaz, Alexandre Grimaldi, Priscilla Thomas Lopes, Melania Murolo, Brendan Evano, Stamatia Gioftsidi, Vincent Laville, Sebastian Mella, Shahragim Tajbakhsh, Glenda Comai

The muscle stem cell (MuSC) population is recognized as functionally heterogeneous. Cranial muscle stem cells, which originate from head mesoderm, can have greater proliferative capacity in culture and higher regenerative potential in transplantation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d5bf0faf77d8fc5a8a8df1310d7d96
https://hal-pasteur.archives-ouvertes.fr/pasteur-04025397

Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation

Autor: Wolf Reik, Irene Hernando-Herraez, Shahragim Tajbakhsh, Glenda Comai, Pierre-Henri Commere, Thomas M. Stubbs, Brendan Evano, Diljeet Gill

Publikováno v: PLoS Genetics, Vol 16, Iss 10, p e1009022 (2020)
PLoS Genetics
PLoS Genetics, Public Library of Science, 2020, 16 (10), pp.e1009022. ⟨10.1371/journal.pgen.1009022⟩
PLoS Genetics, 2020, 16 (10), pp.e1009022. ⟨10.1371/journal.pgen.1009022⟩

Adult skeletal muscles are maintained during homeostasis and regenerated upon injury by muscle stem cells (MuSCs). A heterogeneity in self-renewal, differentiation and regeneration properties has been reported for MuSCs based on their anatomical loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796dbd7425a91d3055abcab991a2235b
https://doaj.org/article/44796252406a407a85e793d21603b3eb

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

Autor: Shahragim Tajbakhsh, Wolf Reik, Brendan Evano, Thomas M. Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen J. Clark, Simon Andrews, Irene Hernando-Herraez

Publikováno v: Nature Communications
Nature Communications, 2019, 10 (1), pp.4361. ⟨10.1038/s41467-019-12293-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4361. ⟨10.1038/s41467-019-12293-4⟩

Age-related tissue alterations have been associated with a decline in stem cell number and function. Although increased cell-to-cell variability in transcription or epigenetic marks has been proposed to be a major hallmark of ageing, little is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102a8ae6840250a67fc2cc2bb49001d
https://hal-pasteur.archives-ouvertes.fr/pasteur-03105560/document