Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Brendan Colgan"'
Autor:
Mirco Govoni, Michele Bassi, Stefano Vezzoli, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Stefano Petruzzelli, Gera L. Jellema, Ebenezer K. Afolabi, Brendan Colgan, Brian Leaker, Oliver Kornmann, Kai Michael Beeh, Henrik Watz, Dave Singh
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome g
Externí odkaz:
https://doaj.org/article/329954abcd014a2482d1ae81f7bede63
Autor:
Dave Singh, Kai Michael Beeh, Brendan Colgan, Oliver Kornmann, Brian Leaker, Henrik Watz, Germano Lucci, Silvia Geraci, Aida Emirova, Mirco Govoni, Marie Anna Nandeuil
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background CHF6001 is a novel inhaled phosphodiesterase-4 inhibitor. This Phase IIa study assessed the effects of CHF6001 on markers of inflammation in induced sputum and blood in patients with chronic obstructive pulmonary disease (COPD). M
Externí odkaz:
https://doaj.org/article/01259f933c6244f7abadad184d308298
Effects of Videogaming on Attention and Conduct in Adolescents with Tourette’s Syndrome (P12-11.010)
Publikováno v:
Wednesday, April 26.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a74fb782264e0077e527a72f1d0a13ea
https://doi.org/10.1212/wnl.0000000000202093
https://doi.org/10.1212/wnl.0000000000202093
COPD sputum eosinophils: relationship to blood eosinophils and the effect of inhaled PDE4 inhibition
Autor:
Oliver Kornmann, Brendan Colgan, Aida Emirova, Brian Leaker, Debora Santoro, Dave Singh, Marie Anna Nandeuil, Deborah Balzano, Henrik Watz, Germano Lucci, Mirco Govoni, Kai Michael Beeh
Publikováno v:
The European Respiratory Journal
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Patients with COPD who have higher eosinophil numbers in the airways and peripheral blood demonstrate a greater clinical response to inhaled corticosteroids (ICS) [1–3]. Furthermore, the effect of the oral phosphodiesterase-4 (PDE4) inhibitor roflu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb32bed2c3874cb172492928179b145
http://europepmc.org/articles/PMC7406856
http://europepmc.org/articles/PMC7406856
Autor:
Brendan Colgan, Michele Bassi, Stefano Vezzoli, Mirco Govoni, Germano Lucci, Oliver Kornmann, Ebenezer K. Afolabi, Aida Emirova, Gera L. Jellema, Kai Michael Beeh, Dave Singh, Marie Anna Nandeuil, Brian Leaker, Stefano Petruzzelli, Henrik Watz
Publikováno v:
Respiratory Research
Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020)
Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020)
Background Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152ce93e30a4349557d5903e780fb460
https://pubmed.ncbi.nlm.nih.gov/32197620
https://pubmed.ncbi.nlm.nih.gov/32197620
Autor:
Germano Lucci, Aida Emirova, Silvia Geraci, Brian Laeker, Kai Michael Beeh, Mirco Govoni, Michele Bassi, Oliver Kornmann, Dave Singh, Henrik Watz, Marie Anna Nandeuil, Brendan Colgan, Emanuele Calabro Rocco
Publikováno v:
Airway pharmacology and treatment.
Background: CHF6001 is a selective inhaled PDE4i (NEXThaler®). The aim of this study was to assess the effects of CHF6001 on markers of inflammation in sputum and blood. Methods: In this randomized, double-blind, 3-way crossover study, moderate-to-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf0ea4c0f3d9df635a092510f61be3a5
https://doi.org/10.1183/13993003.congress-2019.pa2044
https://doi.org/10.1183/13993003.congress-2019.pa2044
Autor:
Aida Emirova, Dave Singh, Marie Anna Nandeuil, Mirco Govoni, Henrik Watz, Brian Leaker, Oliver Kornmann, Silvia Geraci, Germano Lucci, Kai Michael Beeh, Brendan Colgan
Publikováno v:
Respiratory Research
Respiratory Research, Vol 20, Iss 1, Pp 1-12 (2019)
Respiratory Research, Vol 20, Iss 1, Pp 1-12 (2019)
Background CHF6001 is a novel inhaled phosphodiesterase-4 inhibitor. This Phase IIa study assessed the effects of CHF6001 on markers of inflammation in induced sputum and blood in patients with chronic obstructive pulmonary disease (COPD). Methods Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7b5826d9997cc5bb3bd015ee0da397
https://pubmed.ncbi.nlm.nih.gov/31399091
https://pubmed.ncbi.nlm.nih.gov/31399091
Autor:
Aida Emirova, Dave Singh, Marie Anna Nandeuil, Brendan Colgan, Germano Lucci, Oliver Kornmann, Brianr R. Leaker, Mirco Govoni, Silvia Geraci, Kai Michael Beeh, E. Calabro Rocco, Henrik Watz
Publikováno v:
D101. CLINICAL AND TRANSLATIONAL STUDIES IN ASTHMA AND COPD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcab39aa6ff2a02ce9b47eca747abcb4
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7095
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7095