Výsledky vyhledávání - "Brendan C.O. Muldoon"

Physicochemical Characterization of Bioactive Polyacrylic Acid Organogels as Potential Antimicrobial Implants for the Buccal Cavity

Autor: Brendan C.O. Muldoon, Gavin Andrews, David S. Jones, F.Dominic Sanderson, A. David Woolfson

Publikováno v: Biomacromolecules. 9:624-633

This study describes the formulation and physicochemical characterization of poly(acrylic acid) (PAA) organogels, designed as bioactive implants for improved treatment of infectious diseases of the oral cavity. Organogels were formulated containing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d9135bfa346483f55a6ef92dbc68af
https://doi.org/10.1021/bm700597e

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An Examination of the Rheological and Mucoadhesive Properties of Poly(Acrylic Acid) Organogels Designed as Platforms for Local Drug Delivery to the Oral Cavity

Autor: Brendan C.O. Muldoon, David S. Jones, A. David Woolfson, F.Dominic Sanderson

Publikováno v: Journal of Pharmaceutical Sciences. 96:2632-2646

This study examined the rheological/mucoadhesive properties of poly(acrylic acid) PAA organogels as platforms for drug delivery to the oral cavity. Organogels were prepared using PAA (3%, 5%, 10% w/w) dissolved in ethylene glycol (EG), propylene glyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5907ae8034b63d7193b0a01513cb45e9
https://doi.org/10.1002/jps.20771

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Rheological destructuring of aqueous gels composed of cellulose ethers following storage in the presence of redox agents

Autor: Brendan C.O. Muldoon, F.Dominic Sanderson, A. David Woolfson, David S. Jones

Publikováno v: Journal of Applied Polymer Science. 98:852-859

Despite their widespread use, there is a paucity of information concerning the effect of storage on the rheological properties of pharmaceutical gels that contain organic and inorganic additives. Therefore, this study examined the effect of storage (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84980f011e4846dec7d0b31a85d5b89a
https://doi.org/10.1002/app.22180

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Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc

Autor: Claire J. Forbes, R. Karl Malcolm, Leslie Geer, Laura A. Doyle, Per Johan Klasse, A. David Woolfson, Robin J. Shattock, Laurie Goldman, Ronald S. Veazey, John P. Moore, Brendan C.O. Muldoon, Mark Mitchnick, Deborah Lowry

Aqueous semi-solid polymeric gels, such as those based on hydroxyethylcellulose (HEC) and polyacrylic acid (e.g. Carbopol®), have a long history of use in vaginal drug delivery. However, despite their ubiquity, they often provide sub-optimal clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126c007c725ddb83243030dbea01184c
https://publications.aston.ac.uk/id/eprint/16740/1/nihms319663.pdf

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Moisture-activated rheological structuring of nonaqueous poloxamine-poly(acrylic acid) systems designed as novel biomedical implants

Autor: F.Dominic Sanderson, A. David Woolfson, Brendan C.O. Muldoon, Gavin Andrews, David S. Jones, Colin P. McCoy

Publikováno v: Journal of pharmaceutical sciences. 99(4)

This study reports the formulation/characterisation of novel polymeric platforms designed to behave as low-viscosity systems in the nonaqueous state, however, following uptake of aqueous fluids, exhibit rheological structuring and mucoadhesion. The r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c93e0189692e9fd8d884a848bb1c3b5
https://pubmed.ncbi.nlm.nih.gov/19904825

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