Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy

Autor: Katherine Rankin, Priyanka Hastak, Alexander Wong, Sarah C. Sasson, Brendan Beaton, Avani Yeola, Andrew Warden, Stuart Turville, Anthony D. Kelleher, Fabienne Brilot, Judith Trotman

Publikováno v: eJHaem, Vol 4, Iss 3, Pp 728-732 (2023)

Abstract Patients with Waldenström macroglobulinaemia (WM) are at increased risk of severe COVID‐19 infection and have poor immune responses to COVID‐19 vaccination. This study assessed whether a closely monitored pause in Bruton's Tyrosine Kina

Externí odkaz: https://doaj.org/article/71d8b842c3924d84ac1c441d4c9116d8

Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial

Autor: David I Marks, Amy A Kirkwood, Clare J Rowntree, Melanie Aguiar, Katharine E Bailey, Brendan Beaton, Paul Cahalin, Anna Z Castleton, Laura Clifton-Hadley, Mhairi Copland, Anthony H Goldstone, Richard Kelly, Emma Lawrie, SooWah Lee, Andrew K McMillan, Mary Frances McMullin, Tobias F Menne, Rachel J Mitchell, Anthony V Moorman, Bela Patel, Pip Patrick, Paul Smith, David Taussig, Deborah Yallop, Krisztina Zuborne Alapi, Adele K Fielding

Publikováno v: Marks, D I, Kirkwood, A A, Rowntree, C J, Aguiar, M, Bailey, K E, Beaton, B, Cahalin, P, Castleton, A Z, Clifton-Hadley, L, Copland, M, Goldstone, A H, Kelly, R, Lawrie, E, Lee, S, McMillan, A K, McMullin, M F, Menne, T F, Mitchell, R J, Moorman, A V, Patel, B, Patrick, P, Smith, P, Taussig, D, Yallop, D, Alapi, K Z & Fielding, A K 2022, ' Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial ', The Lancet Haematology, vol. 9, no. 4, pp. e262-e275 . https://doi.org/10.1016/S2352-3026(22)00038-2

BACKGROUND: Treatment for adults with acute lymphoblastic leukaemia requires improvement. UKALL14 was a UK National Cancer Research Institute Adult ALL group study that aimed to determine the benefit of adding the anti-CD20 monoclonal antibody, ritux

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb76af476ccd2c9482ebad9b933c975
https://doi.org/10.1016/s2352-3026(22)00038-2

Inexpensive monitoring of flying insect activity and abundance using wildlife cameras

Autor: Therese Reber, Brendan Beaton, Eric J. Warrant, Jesse R. A. Wallace, David Dreyer

The ability to measure flying insect activity and abundance is important for ecologists, conservationists and agronomists alike. However, existing methods are laborious and produce data with low temporal resolution (e.g. trapping and direct observati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81d05610ce99da1319a8a1f65527a465
https://doi.org/10.1101/2021.08.24.457487

Efficacy of Vaccine BNT162b2 (Pfizer-BioNTech) in Individuals with Waldenstrom's Macroglobulinemia and Follicular Lymphoma in Australia

Autor: Brendan Beaton, Andrew C. Warden, Ian D. Caterson, Anupriya Aggarwal, Alberto Ospina Stella, Anthony D. Kelleher, Sarah C. Sasson, Fabienne Brilot, Priyanka Hastak, Stuart Turville, Juliette Raedemaeker, Katherine Rankin, Chansavath Phetsouphanh, Judith Trotman, Alexander Wong

Publikováno v: Blood

Introduction Lymphoid malignancies are a risk factor for severe COVID-19. Vaccination with BNT162b2 protects the general population from severe disease, but recent studies have shown limited seroconversion after vaccination in patients with lymphoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28efdd5ff49721c28c181d509d6c192
http://europepmc.org/articles/PMC8701644

The Role of Neutrophils in Measles Virus–mediated Oncolysis Differs Between B-cell Malignancies and Is Not Always Enhanced by GCSF

Autor: Bella Patel, Katharine Bailey, Yu Zhang, Adele K. Fielding, Anna Castleton, Brendan Beaton, Aditi Dey

Publikováno v: Molecular Therapy. 24(1):184-192

The mechanism by which oncolytic measles virus (MV) kills cancer cells remains obscure. We previously showed that neutrophils are involved in MV-mediated tumor regressions and become activated, upon MV infection. In the present study, we attempted to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2875cab9303bcb3c30f3b48bd946c070