Výsledky vyhledávání - "Brendan A. Leroy"

Long-Term High-Level Reconstitution of NADPH Oxidase Activity in Murine X-Linked Chronic Granulomatous Disease Using a Bicistronic Vector Expressing gp91phoxand a ΔLNGFR Cell Surface Marker

Autor: Brendan A. Leroy, Mohammed A. Sadat, Mary C. Dinauer, So Saulnier, Manuel Grez, Johann Peter Hossle, Nancy Pech

Publikováno v: Human Gene Therapy. 14:651-666

A murine model of X-linked chronic granulomatous disease (X-CGD), an inherited immune deficiency with absent phagocyte NADPH oxidase activity caused by defects in the gp91(phox) gene, was used to evaluate a bicistronic retroviral vector in which expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087cf00af7f37df4889a6c18de348133
https://doi.org/10.1089/104303403321618164

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Mutagenesis of p22 Histidine 94

Autor: Karla J. Biberstine-Kinkade, Mary C. Dinauer, Brendan A. Leroy, Natalie D. Stull, Lixin Yu, Andrew R. Cross, Shelley Bennett

Publikováno v: Journal of Biological Chemistry. 277:30368-30374

The NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O2 to generate superoxide (O2*-), the precursor of microbicidal oxygen species that play an important role in host defense. Flavocytochrome b558, a heterodimeric oxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::873ba8178db2010ab983f2eb805ff244
https://doi.org/10.1074/jbc.m203993200

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Heme-ligating Histidines in Flavocytochromeb 558

Autor: William M. Nauseef, Mary C. Dinauer, Karla J. Biberstine-Kinkade, Brendan A. Leroy, Rebecca I. Epstein, Frank R. DeLeo

Publikováno v: Journal of Biological Chemistry. 276:31105-31112

The phagocyte NADPH-dependent oxidase generates superoxide (O(2)) by reducing molecular oxygen through flavocytochrome b(558) (flavocytochrome b), a heterodimeric oxidoreductase composed of gp91(phox) and p22(phox) subunits. Although each flavocytoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::560c9c5f107a7a12d5044a58e9143f07
https://doi.org/10.1074/jbc.m103327200

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Akademický článek

Long-Term High-Level Reconstitution of NADPH Oxidase Activity in Murine X-Linked Chronic Granulomatous Disease Using a Bicistronic Vector Expressing gp91^phox and a ΔLNGFR Cell Surface Marker.

Autor: Mohammed A. Sadat, Nancy Pech, So Saulnier, Brendan A. Leroy, Johann P. Hossle, Manuel Grez, Mary C. Dinauer

Publikováno v: Human Gene Therapy; 5/1/2003, Vol. 14 Issue 7, p651-666, 16p

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