Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption

Autor: Robert F. Siliciano, Weimin Liu, Alexa N. Avitto, Michel C. Nussenzweig, Yehuda Z. Cohen, Paul M. Sharp, Michael S. Saag, Ronnie M. Russell, Luis J. Montaner, Frederic Bibollet-Ruche, Ronald G. Collman, George M. Shaw, Pierre Pellegrino, Sonya L. Heath, Julio C. C. Lorenzi, Jesse Connell, Ian Williams, Stephanie Trimboli, Andrew G. Smith, M. Alexandra Monroy, Scott Sherrill-Mix, Yingying Li, Beatrice H. Hahn, Janet M. Siliciano, D. Brenda Salantes, Lindsey J. Plenderleith, Emmanouil Papasavvas, Angharad E. Fenton-May, Julia DeVoto, Katharine J. Bar, Marina Caskey, Marcos V. P. Gondim, Persephone Borrow, Felicity Mampe

Publikováno v: Gondim, M V P, Sherrill-Mix, S, Bibollet-Ruche, F, Russell, R M, Trimboli, S, Smith, A G, Li, Y, Liu, W, Avitto, A N, DeVoto, J C, Connell, J, Fenton-May, A E, Pellegrino, P, Williams, I, Papasavvas, E, Lorenzi, J C C, Brenda Salantes, D, Mampe, F, Alexandra Monroy, M, Cohen, Y Z, Heath, S, Saag, M S, Montaner, L J, Collman, R G, Siliciano, J M, Siliciano, R F, Plenderleith, L J, Sharp, P M, Caskey, M, Nussenzweig, M C, Shaw, G M, Borrow, P, Bar, K J & Hahn, B H 2021, ' Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption ', Science Translational Medicine, vol. 13, no. 576, eabd8179 . https://doi.org/10.1126/SCITRANSLMED.ABD8179
Sci Transl Med

Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1 transmission. However, harnessing these cytokines for HIV-1 cure strategies has been hampered by an incomplete understanding of their antiviral activities at later

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd61e6b06a1340de5cdaf3c9a30f3230
https://hdl.handle.net/20.500.11820/a6051f01-6cf5-434d-b22c-8486e3fd60c2

HIV-1 latent reservoir size and diversity are stable following brief treatment interruption

Autor: Pablo Tebas, Robert F. Siliciano, Mohamed Abdel-Mohsen, Jun Lai, E. Turner Overton, Kevin McCormick, James A. Hoxie, Randall Tressler, Scott Sherrill-Mix, Janet M. Siliciano, Jonathan Z. Li, D. Brenda Salantes, Richard A. Koup, Tuhina Srivastava, Yu Zheng, Felicity Mampe, Gerald H. Learn, Frederic D. Bushman, Subul A. Beg, Katharine J. Bar

Publikováno v: Journal of Clinical Investigation. 128:3102-3115

BACKGROUND. The effect of a brief analytical treatment interruption (ATI) on the HIV-1 latent reservoir of individuals who initiate antiretroviral therapy (ART) during chronic infection is unknown. METHODS. We evaluated the impact of transient viremi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee58aa6a2ce89d8cc213453d53a0db5a
https://doi.org/10.1172/jci120194

CD209a Expression on Dendritic Cells Is Critical for the Development of Pathogenic Th17 Cell Responses in Murine Schistosomiasis

Autor: Joanne M. Russo, D. Brenda Salantes, Miguel J. Stadecker, Bridget Larkin, Nir Hacohen, Stephen C. Bunnell, Raktima Raychowdhury, Cheolho Cheong, Tae J. Yun, Laurence D. Parnell, Holly Ponichtera, Chao-Qiang Lai, Beiyun C. Liu, Mara G. Shainheit

Publikováno v: The Journal of Immunology. 192:4655-4665

In murine schistosomiasis, immunopathology and cytokine production in response to parasite eggs are uneven and strain dependent. CBA/J (CBA) mice develop severe hepatic granulomatous inflammation associated with prominent Th17 cell responses driven b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a53396d4eef522b76826a9efc578f3d
https://doi.org/10.4049/jimmunol.1400121

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.