Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brenda R. Flam"'
Autor:
Alberto Podjarny, Andre Mitschler, Kerry Combs, Evelyn O. Sibley, Al Sabetta, Erin E. McCann, Anne L. Carrington, Eduardo Howard, Diane R. Sawicki, Janet Sredy, Brenda R. Flam, Michael C. Van Zandt
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5661-5675
Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid aldose reductase inhibitors. The compound class features a
Publikováno v:
Journal of Biological Chemistry. 277:25363-25369
Based on the integral role that argininosuccinate synthase (AS) plays in the production of nitric oxide in vascular endothelial cells and urea in liver, an analysis was carried out to determine whether signals reside in the AS mRNA to account for tis
Autor:
Brenda R. Flam, Melissa Harrell-Booth, Larry P. Solomonson, Paul J. Hartmann, Duane C. Eichler
Publikováno v:
Nitric Oxide. 5:187-197
Although normal intracellular levels of arginine are well above the K(m), and should be sufficient to saturate nitric oxide synthase in vascular endothelial cells, nitric oxide production can, nonetheless, be stimulated by exogenous arginine. This ph
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 4 (2013)
Frontiers in Physiology, Vol 4 (2013)
Thioredoxin-interacting protein (TXNIP) has been linked to cell apoptosis and inflammation in a number of diseases, including type 2 diabetes (Shah et al., 2013), atherosclerosis (Berk, 2007), and myocardial ischemia (Yoshioka et al., 2012). TXNIP ha
Publikováno v:
Metabolism. 44:1074-1081
Insulin resistance in the ob/ob mouse model is associated with a reduction in insulin-induced protein-tyrosine phosphorylation in tissues such as liver. To ascertain whether this decrease in phosphorylation may be due to increased phosphatase activit
Autor:
Iwan Gunawan, Diane R. Sawicki, Brenda R. Flam, Laura Seestaller, Brenda Mihan, Donald Sullivan, Michael S. Malamas, Janet Sredy
Publikováno v:
ChemInform. 31
Insulin resistance in the liver and peripheral tissues together with a pancreatic cell defect are the common causes of type 2 diabetes. It is now appreciated that insulin resistance can result from a defect in the insulin receptor signaling system, a
Publikováno v:
IFMBE Proceedings ISBN: 9783642016967
Targeted drug delivery provides an effective means of delivering high concentrations of a therapeutic agent to its sites of action. Bilayer vesicles composed of nonionic surfactants (niosomes) can be manufactured to both attach to specific endothelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5b73f27f68b067ed52b8e4dca6dd223
https://doi.org/10.1007/978-3-642-01697-4_124
https://doi.org/10.1007/978-3-642-01697-4_124
Publikováno v:
Experimental Biology and Medicine. 197:135-143
The ability of aldose reductase inhibitors to prevent the decline in neural Na+,K+-ATPase activity in diabetic rats has not been confirmed by all laboratories. In this study, the efficacy of two structurally different aldose reductase inhibitors was
Publikováno v:
The FASEB Journal. 21
Publikováno v:
Nitric oxide : biology and chemistry. 17(3-4)
Nitric oxide (NO) is an important vasorelaxant produced along with L-citrulline from L-arginine in a reaction catalyzed by endothelial nitric oxide synthase (eNOS). Previous studies suggested that the recycling of L-citrulline to L-arginine is essent