Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Brenda R. Grimes"'
Autor:
Murray Korc, Brittney-Shea Herbert, Riccardo Colombo, Keith L. March, Jose Victorino, Jaesik Jeong, Rachel Gasaway, Lyndsey Brown, Corinne Blackburn, Jesse Gore, Ruchi Bansal, Brenda R. Grimes, Roger B. Slee
PDF - 1019K, Figure S1 The CIN70 signature predicts survival in PDAC patients. Figure S2 Murine PDAC KRC cells exhibit chromosome instability and evidence of a weakened SAC. Figure S3 Clonogenic survival of PANC-1 and BxPC3 cells treated with NMS-P71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e3cdeeafabfe46ea6e105727a39fea
https://doi.org/10.1158/1535-7163.22500747
https://doi.org/10.1158/1535-7163.22500747
Autor:
Murray Korc, Brittney-Shea Herbert, Riccardo Colombo, Keith L. March, Jose Victorino, Jaesik Jeong, Rachel Gasaway, Lyndsey Brown, Corinne Blackburn, Jesse Gore, Ruchi Bansal, Brenda R. Grimes, Roger B. Slee
Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). Although often implicated as a driver of tumor progression and drug resistance, CIN also reduces cell fitness and pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b23d77188bf5b3b19e363caa90ed77
https://doi.org/10.1158/1535-7163.c.6536565.v1
https://doi.org/10.1158/1535-7163.c.6536565.v1
Autor:
Kristin M Sheffield, Jessica R Peachey, Michael Method, Brenda R Grimes, Jacqueline Brown, Kim Saverno, Tomoko Sugihara, Zhanglin Lin Cui, Kimberley T Lee
Publikováno v:
Future oncology (London, England). 18(21)
Aim: To assess invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS) in hormone receptor-positive, HER2-negative early breast cancer with combined clinicopathological criteria from monarchE, a phase III study of abemaciclib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b92d71c304b27b3b42d3dce374bcff
https://pubmed.ncbi.nlm.nih.gov/35611679
https://pubmed.ncbi.nlm.nih.gov/35611679
Autor:
Masakazu Toi, Frances Boyle, Young-Hyuck Im, Mattea Reinisch, David Molthrop, Zefei Jiang, Ran Wei, Francisco Sapunar, Brenda R Grimes, Sarah Cassidy Nabinger, Stephen R D Johnston
Publikováno v:
The oncologist.
The monarchE Cohort 1 patient population was enrolled based on high-risk clinicopathological features that can easily be identified as part of routine clinical breast cancer evaluation. Efficacy data from Cohort 1 demonstrate substantial evidence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad63215565c227bc2d4d45b673701ae
https://pubmed.ncbi.nlm.nih.gov/36342342
https://pubmed.ncbi.nlm.nih.gov/36342342
Autor:
Brittney-Shea Herbert, Brenda R Grimes, Wei Min Xu, Michael Werner, Christopher Ward, Sandro Rossetti, Peter Harris, Elsa Bello-Reuss, Heather H Ward, Caroline Miller, Vincent H Gattone, Carrie L Phillips, Angela Wandinger-Ness, Robert L Bacallao
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55191 (2013)
Autosomal dominant polycystic kidney disease (ADPKD) is associated with a variety of cellular phenotypes in renal epithelial cells. Cystic epithelia are secretory as opposed to absorptive, have higher proliferation rates in cell culture and have some
Externí odkaz:
https://doaj.org/article/1affffd7c15345f98c11b62caccdf1ff
Autor:
Hiroshi Masumoto, Brenda R. Grimes, Natalay Kouprina, Alexander Samoshkin, William C. Earnshaw, Ruchi Bansal, Artem V. Kononenko, Hee Sheung Lee, Nicholas C.O. Lee, Vladimir Larionov
Publikováno v:
BMC Cancer
Lee, H-S, Lee, N C O, Samoshkin, A, Kononenko, A V, Kouprina, N, Larionov, V, Grimes, B R, Bansal, R, Masumoto, H & Earnshaw, W C 2013, ' A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells ', BMC Cancer, vol. 13, 252 . https://doi.org/10.1186/1471-2407-13-252
Lee, H-S, Lee, N C O, Samoshkin, A, Kononenko, A V, Kouprina, N, Larionov, V, Grimes, B R, Bansal, R, Masumoto, H & Earnshaw, W C 2013, ' A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells ', BMC Cancer, vol. 13, 252 . https://doi.org/10.1186/1471-2407-13-252
Background Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer genome evolution and tumor progression, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f68d760a0444873d1d6aafe4bba815
Autor:
Jessica R. Peachey, Michael Method, Jacqueline Brown, Kristin M Sheffield, Kimberley T. Lee, Yajun Emily Zhu, Brenda R. Grimes, Kim Saverno
Publikováno v:
Journal of Clinical Oncology. 39:e18581-e18581
e18581 Background: While most patients (pts) with HR+, HER2- early breast cancer (EBC) do not experience disease recurrence, those with high risk clinicopathologic features may have recurrence within the first few years on adjuvant endocrine therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9c24ce3cbceb93249466152fbcd5e18
https://doi.org/10.1200/jco.2021.39.15_suppl.e18581
https://doi.org/10.1200/jco.2021.39.15_suppl.e18581
Autor:
Brenda R. Grimes, Roger B. Slee, Nazmul Huda, David Gilley, LiRen Tu, Liang Cheng, Alison M. Bates
Publikováno v:
Molecular Carcinogenesis. 55:842-852
A critical function of the telomere is to disguise chromosome ends from cellular recognition as double strand breaks, thereby preventing aberrant chromosome fusion events. Such chromosome end-to-end fusions are known to initiate genomic instability v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e94e64e52bb2c00893e89a5f0f4cb51
https://doi.org/10.1002/mc.22326
https://doi.org/10.1002/mc.22326
Autor:
Nazmul Huda, David Gilley, Hiromi Tanaka, Matthew J. Beam, Satoshi Abe, Li Ren Tu, Brenda R. Grimes
Publikováno v:
Proceedings of the National Academy of Sciences. 109:14098-14103
Several lines of evidence suggest that defects in telomere maintenance play a significant role in the initiation of genomic instability during carcinogenesis. Although the general concept of defective telomere maintenance initiating genomic instabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f534a721a67c297251e403cb4bf6a591
https://doi.org/10.1073/pnas.1120062109
https://doi.org/10.1073/pnas.1120062109
Autor:
Roger B. Slee, Milan Radovich, Gail H. Vance, Brittney-Shea Herbert, D. Schindelhauer, Brenda R. Grimes, S. Christan, Robert J. Hickey, Camie M. Steiner, T. Schwarz, Bryan P. Schneider
Publikováno v:
Oncogene. 31:3244-3253
Many tumors exhibit elevated chromosome mis-segregation termed chromosome instability (CIN), which is likely to be a potent driver of tumor progression and drug resistance. Causes of CIN are poorly understood but probably include prior genome tetrapl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9596f423b2bc2c81dbe42fe9cea4ddf0
https://doi.org/10.1038/onc.2011.502
https://doi.org/10.1038/onc.2011.502