Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brenda R S Temple"'
Autor:
Dustin E Bosch, Adam J Kimple, Robin E Muller, Patrick M Giguère, Mischa Machius, Francis S Willard, Brenda R S Temple, David P Siderovski
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003040 (2012)
Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative agent of amoeb
Externí odkaz:
https://doaj.org/article/4362270682cc4067a9e0e1c85c876670
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42633 (2012)
Plants recognize microbes via specific pattern recognition receptors that are activated by microbe-associated molecular patterns (MAMPs), resulting in MAMP-triggered immunity (MTI). Successful pathogens bypass MTI in genetically diverse hosts via dep
Externí odkaz:
https://doaj.org/article/804d0639aff8498ea410591bf9b40613
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 10, p e1000962 (2010)
Heterotrimeric G proteins act as the physical nexus between numerous receptors that respond to extracellular signals and proteins that drive the cytoplasmic response. The Gα subunit of the G protein, in particular, is highly constrained due to its m
Externí odkaz:
https://doaj.org/article/d6e20b0dcf714d23adba38d7bfeb4059
Autor:
Denise G Teotico, Monica L Frazier, Feng Ding, Nikolay V Dokholyan, Brenda R S Temple, Matthew R Redinbo
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 7, p e1000111 (2008)
Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a conserved activation function-2 (AF-2) surface. While most nuclear receptor LBDs form homo- o
Externí odkaz:
https://doaj.org/article/f1758556d4e849d491ec7f8883923860
Autor:
Danielle L. Chappell, Praneet K. Sandhu, Jason P. Wong, Aadra P. Bhatt, Xiaoxi Liu, Sara J. Buhrlage, Brenda R. S. Temple, M. Ben Major, Blossom Damania
Publikováno v:
Journal of Virology. 97
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi sarcoma (KS), the plasmablastic form of multicentric Castleman’s disease, and primary effusion lymphoma. In sub-Saharan Africa, KS is the most common HIV-related ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2f8514e477cae16dfc3ceb4bcd8bcef
https://doi.org/10.1128/jvi.01763-22
https://doi.org/10.1128/jvi.01763-22
Autor:
Aaron T Crain, Stephen Klusza, Robin L Armstrong, Priscila Santa Rosa, Brenda R S Temple, Brian D Strahl, Daniel J McKay, A Gregory Matera, Robert J Duronio
Publikováno v:
Genetics
Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects of genome organization and function. Loss-of-function mutations in Drosophila melanogaster Set8 or mammalian KMT5A prevent H4K20me1 and disr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40b1cb886b1e522428935e1d6454897
https://doi.org/10.1093/genetics/iyac054
https://doi.org/10.1093/genetics/iyac054
Autor:
Kaeli A Welsh, Derek L Bolhuis, Anneroos E Nederstigt, Joshua Boyer, Brenda R S Temple, Thomas Bonacci, Li Gu, Alban Ordureau, J Wade Harper, Joshua P Steimel, Qi Zhang, Michael J Emanuele, Joseph S Harrison, Nicholas G Brown
Publikováno v:
The EMBO Journal. 41
Polyubiquitination by E2 and E3 enzymes is crucial to cell cycle control, epigenetic regulation, and development. The hallmark of the E2 family is the ubiquitin (Ub)-conjugating (UBC) domain that forms a dynamic thioester conjugate with ubiquitin (E2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00673c4b115bfcca0362b69cd17c6471
https://doi.org/10.15252/embj.2021108823
https://doi.org/10.15252/embj.2021108823
Publikováno v:
Arthritis Research & Therapy
Patients with systemic autoimmune diseases usually produce high levels of antibodies to self-antigens (autoantigens). The repertoire of common autoantigens is remarkably limited, yet no readily understandable shared thread links these apparently dive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6445f84e02a7bc28024e733f1e14b230
https://pubmed.ncbi.nlm.nih.gov/16277689
https://pubmed.ncbi.nlm.nih.gov/16277689
Publikováno v:
The Journal of biological chemistry. 279(21)
Protease-activated receptor-1 (PAR1), a G protein-coupled receptor (GPCR) for thrombin, is irreversibly proteolytically activated, internalized, and then sorted to lysosomes and degraded. Internalization and lysosomal sorting of activated PAR1 is cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37cabee3f027b6d21a42e37bd1275a2b
https://pubmed.ncbi.nlm.nih.gov/15023990
https://pubmed.ncbi.nlm.nih.gov/15023990