Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brenda Marrero‐Rosado"'
Autor:
Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain
Publikováno v:
Epilepsia Open, Vol 6, Iss 4, Pp 757-769 (2021)
Abstract Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl
Externí odkaz:
https://doaj.org/article/8353077f8b364edd90a8daf425f335b3
Autor:
Lucille Lumley, Fu Du, Brenda Marrero-Rosado, Michael Stone, Zora-Maya Keith, Caroline Schultz, Kimberly Whitten, Katie Walker, Cindy Acon-Chen, Linnzi Wright, Tsung-Ming Shih
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 896-907 (2021)
Animal models are essential for evaluating the toxicity of chemical warfare nerve agents (CWNAs) to extrapolate to human risk and are necessary to evaluate the efficacy of medical countermeasures. The Göttingen minipig is increasingly used for toxic
Externí odkaz:
https://doaj.org/article/15f8b06964f947a390606a8fa34d62cd
Autor:
Lucille Lumley, Dennis Miller, William T. Muse, Brenda Marrero‐Rosado, Marcio de Araujo Furtado, Michael Stone, Jeffrey McGuire, Christopher Whalley
Publikováno v:
Epilepsia Open, Vol 4, Iss 3, Pp 382-396 (2019)
Abstract Objective Our objective was to evaluate the protective efficacy of the neurosteroid pregnanolone (3α‐hydroxy‐5β pregnan‐20‐one), a GABAA receptor‐positive allosteric modulator, as an adjunct to benzodiazepine therapy against the
Externí odkaz:
https://doaj.org/article/42d2473c8f4c4c4f928e47706e64ac82
Autor:
Lucille A. Lumley, Franco Rossetti, Marcio de Araujo Furtado, Brenda Marrero-Rosado, Caroline R. Schultz, Mark K. Schultz, Jerome Niquet, Claude G. Wasterlain
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
This article investigated the efficacy of the combination of antiepileptic drug therapy in protecting against soman-induced seizure severity, epileptogenesis and performance deficits. Adult male rats with implanted telemetry transmitters for continuo
Externí odkaz:
https://doaj.org/article/05c592851a2d4f11b2f42351c5b2da20
Autor:
Loro L. Kujjo, Eun A. Chang, Ricardo J. G. Pereira, Shilpa Dhar, Brenda Marrero-Rosado, Satyaki Sengupta, Hongbing Wang, Jose B. Cibelli, Gloria I. Perez
Publikováno v:
PLoS ONE, Vol 6, Iss 3 (2011)
Externí odkaz:
https://doaj.org/article/84c1ddbfdb344d409336c53faf199cd8
Autor:
Loro L Kujjo, Eun A Chang, Ricardo J G Pereira, Shilpa Dhar, Brenda Marrero-Rosado, Satyaki Sengupta, Hongbing Wang, Jose B Cibelli, Gloria I Perez
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17877 (2011)
To our knowledge, there is no report on long-term reproductive and developmental side effects in the offspring of mothers treated with a widely used chemotherapeutic drug such as doxorubicin (DXR), and neither is there information on transmission of
Externí odkaz:
https://doaj.org/article/b29e976d0d56477f8a22f0e78b6d6d1d
Autor:
Jerome Niquet, Caroline R. Schultz, Brenda Marrero-Rosado, Franco Rossetti, Michael F. Stone, Claude G. Wasterlain, Lucille A. Lumley
Publikováno v:
Epilepsia Open, Vol 6, Iss 4, Pp 757-769 (2021)
Epilepsia Open
Epilepsia Open
Objective Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABAA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888b700314b4f4ce5ef649e2f6874642
https://doaj.org/article/8353077f8b364edd90a8daf425f335b3
https://doaj.org/article/8353077f8b364edd90a8daf425f335b3
Autor:
Marcio de Araujo Furtado, Brenda Marrero-Rosado, Michael F. Stone, Erica Kundrick, Lucille A. Lumley, Caroline R. Schultz
Publikováno v:
Neurotoxicology
Cannabidiol, approved for treatment of pediatric refractory epilepsy, has anti-seizure effects in various animal seizure models. Chemical warfare nerve agents, including soman, are organophosphorus chemicals that can induce seizure and death if untre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e569ee3a5918d2776ec1fc215871b28
https://doi.org/10.1016/j.neuro.2020.12.002
https://doi.org/10.1016/j.neuro.2020.12.002
Autor:
Katie Walker, Linnzi K.M. Wright, Tsung-Ming Shih, Fu Du, Michael F. Stone, Zora-Maya Keith, Caroline R. Schultz, Lucille A. Lumley, Brenda Marrero-Rosado, Kimberly A. Whitten, Cindy Acon-Chen
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 896-907 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757661aa0cf9bbfbadc91ef4471049fd
http://www.sciencedirect.com/science/article/pii/S2214750021000810
http://www.sciencedirect.com/science/article/pii/S2214750021000810
Autor:
Robyn B. Lee-Stubbs, Caroline R. Schultz, Lucille A. Lumley, Brenda Marrero-Rosado, Marcio de Araujo Furtado, Erica Kundrick, Michael F. Stone, Katie Walker
Publikováno v:
Ann N Y Acad Sci
Chemical warfare nerve agent exposure leads to status epilepticus (SE) that may progress to epileptogenesis and severe brain pathology when benzodiazepine treatment is delayed. We evaluated the dose–response effects of delayed midazolam on toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5368ac9f2f25277a9abddfcf1f3bb06
https://doi.org/10.1111/nyas.14311
https://doi.org/10.1111/nyas.14311