Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

Autor: Li, Wang, Markus H, Kainulainen, Nannan, Jiang, Han, Di, Gaston, Bonenfant, Lisa, Mills, Michael, Currier, Punya, Shrivastava-Ranjan, Brenda M, Calderon, Mili, Sheth, Brian R, Mann, Jaber, Hossain, Xudong, Lin, Sandra, Lester, Elizabeth A, Pusch, Joyce, Jones, Dan, Cui, Payel, Chatterjee, M Harley, Jenks, Esther K, Morantz, Gloria P, Larson, Masato, Hatta, Jennifer L, Harcourt, Azaibi, Tamin, Yan, Li, Ying, Tao, Kun, Zhao, Kristine, Lacek, Ashley, Burroughs, Wei, Wang, Malania, Wilson, Terianne, Wong, So Hee, Park, Suxiang, Tong, John R, Barnes, Mark W, Tenforde, Wesley H, Self, Nathan I, Shapiro, Matthew C, Exline, D Clark, Files, Kevin W, Gibbs, David N, Hager, Manish, Patel, Alison L, Halpin, Laura K, McMullan, Justin S, Lee, Hongjie, Xia, Xuping, Xie, Pei-Yong, Shi, C Todd, Davis, Christina F, Spiropoulou, Natalie J, Thornburg, M Steven, Oberste, Vivien G, Dugan, David E, Wentworth, Xiao-Yu, Zheng

Publikováno v: Nature Communications. 13

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were designated as variants of concern/interest (V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445364d5fe3d0c7ce3c81f402107a48f
https://doi.org/10.1038/s41467-022-31929-6

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

Autor: Lorenz Ulrich, Nico Joel Halwe, Adriano Taddeo, Nadine Ebert, Jacob Schön, Christelle Devisme, Bettina Salome Trüeb, Bernd Hoffmann, Manon Wider, Xiaoyu Fan, Meriem Bekliz, Manel Essaidi-Laziosi, Marie Luisa Schmidt, Daniela Niemeyer, Victor Max Corman, Anna Kraft, Aurélie Godel, Laura Laloli, Jenna N. Kelly, Brenda M. Calderon, Angele Breithaupt, Claudia Wylezich, Inês Berenguer Veiga, Mitra Gultom, Sarah Osman, Bin Zhou, Kenneth Adea, Benjamin Meyer, Christiane S. Eberhardt, Lisa Thomann, Monika Gsell, Fabien Labroussaa, Jörg Jores, Artur Summerfield, Christian Drosten, Isabella Anne Eckerle, David E. Wentworth, Ronald Dijkman, Donata Hoffmann, Volker Thiel, Martin Beer, Charaf Benarafa

Publikováno v: Nature
Ulrich, Lorenz; Halwe, Nico Joel; Taddeo, Adriano; Ebert, Nadine; Schön, Jacob; Devisme, Christelle; Trüeb, Bettina Salome; Hoffmann, Bernd; Wider, Manon; Fan, Xiaoyu; Bekliz, Meriem; Essaidi-Laziosi, Manel; Schmidt, Marie Luisa; Niemeyer, Daniela; Corman, Victor Max; Kraft, Anna; Godel, Aurélie; Laloli, Laura; Kelly, Jenna N; Calderon, Brenda M; ... (2022). Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta. Nature, 602(7896), pp. 307-313. Springer Nature 10.1038/s41586-021-04342-0

Emerging variants of concern (VOCs) are driving the COVID-19 pandemic1,2. Experimental assessments of replication and transmission of major VOCs and progenitors are needed to understand the mechanisms of replication and transmission of VOCs3. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72468d93d7b03eae09f65818ba78d565
https://pubmed.ncbi.nlm.nih.gov/34937050

Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency

Autor: Kathleen E. Sullivan, Paul Gray, Debayan Dey, Lars M. Koenig, Daniel F. R. Boehmer, Davide Montin, Matthias Griese, Tomohiro Morio, Tsubasa Okano, Hirokazu Kanegane, Thomas Magg, Francesco Licciardi, Samantha L. Schwartz, Julia Ley-Zaporozhan, Andrés Caballero-Oteyza, Meino Rohlfs, Karl Reiter, Esther N. Park, Jennifer Heimall, Kazutoshi Cho, Michael H. Albert, Brenda M. Calderon, Kento Inoue, Christoph Walz, Christoph Klein, Fabian Hauck, Ronald M. Ferdman, Graeme L. Conn

Analysis of autoinflammatory and immunodeficiency disorders elucidates human immunity and fosters the development of targeted therapies. Oligoadenylate synthetase 1 is a type I interferon-induced, intracellular double-stranded RNA (dsRNA) sensor that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5d3086f2b9ce81b7c525bee36de15a
https://hdl.handle.net/2318/1878269

Endothelial cell‐secreted MIF reduces pericyte contractility and enhances neutrophil extravasation

Autor: Yue Hou, Yi Zhang, Richard Bucala, Brenda M. Calderon, Rebecca Liu, Maor Sauler, Jordan S. Pober, Lin Leng, Pathricia V. Tilstam, Mariah R. Harris, Amanda S. Pellowe, Jonathan Merola, Anjelica L. Gonzalez, Holly M. Lauridsen, Patty J. Lee

Publikováno v: The FASEB Journal. 33:2171-2186

Dysregulated neutrophil extravasation contributes to the pathogenesis of many inflammatory disorders. Pericytes (PCs) have been implicated in the regulation of neutrophil transmigration, and previous work demonstrates that endothelial cell (EC)-deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5478e923c6e2010a5dd10f31f51420f6
https://doi.org/10.1096/fj.201800480r

Dysregulation of M segment gene expression contributes to influenza A virus host restriction

Autor: John Steel, Brenda M. Calderon, Ketaki Ganti, Shamika Danzy, Nathan T. Jacobs, Megan R. Hockman, Graeme L. Conn, Anice C. Lowen, Gabrielle K. Delima

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 8, p e1007892 (2019)

The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations. To elucidate the genetic contributions of the M segment to host adaptation, and the underlying mechanisms, we examined a panel of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16147d5d24e98b9592f77703917d4b25
http://europepmc.org/articles/PMC6695095