Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Brenda L Bass"'
Autor:
Claudia D Consalvo, Adedeji M Aderounmu, Helen M Donelick, P Joseph Aruscavage, Debra M Eckert, Peter S Shen, Brenda L Bass
Publikováno v:
eLife, Vol 13 (2024)
Invertebrates use the endoribonuclease Dicer to cleave viral dsRNA during antiviral defense, while vertebrates use RIG-I-like Receptors (RLRs), which bind viral dsRNA to trigger an interferon response. While some invertebrate Dicers act alone during
Externí odkaz:
https://doaj.org/article/a4b7fc7d9f3141feb17511bbe5b926d0
Publikováno v:
eLife, Vol 12 (2023)
Antiviral defense in ecdysozoan invertebrates requires Dicer with a helicase domain capable of ATP hydrolysis. But despite well-conserved ATPase motifs, human Dicer is incapable of ATP hydrolysis, consistent with a muted role in antiviral defense. To
Externí odkaz:
https://doaj.org/article/b8b7ef5a2534413491d9bf54bff6ef46
Publikováno v:
eLife, Vol 10 (2021)
Some RIG-I-like receptors (RLRs) discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3’-overhanging termini. We investigated the transient k
Externí odkaz:
https://doaj.org/article/3c5c4f78c71b441f8a641c0c3cbfd1db
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11217 (2010)
While studying small noncoding RNA in C. elegans, we discovered that protocols used for isolation of RNA are contaminated with small DNA pieces. After electrophoresis on a denaturing gel, the DNA fragments appear as a ladder of bands, approximately 1
Externí odkaz:
https://doaj.org/article/52c50525053e47128cfcb53a93f7595d
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4052 (2008)
C. elegans Dicer requires an accessory double-stranded RNA binding protein, RDE-4, to enact the first step of RNA interference, the cleavage of dsRNA to produce siRNA. While RDE-4 is typically essential for RNAi, we report that in the presence of hig
Externí odkaz:
https://doaj.org/article/0606cd392dd5475499f7ff2330d8ae19
Publikováno v:
Microscopy and Microanalysis. 27:1122-1124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99a497c4a95ff6c1be5282cfc88bbf29
https://doi.org/10.1017/s1431927621004219
https://doi.org/10.1017/s1431927621004219
Publikováno v:
Chem Commun (Camb)
Dicer-2 cleaves double-stranded RNA (dsRNA) into siRNAs in a terminus-dependent manner as part of D. melanogaster’s RNA interference pathway. Using ultrafast fluorescence, we probe the local environment of chromophores at the dsRNA terminus upon bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89322bc12e28c52b7392fd3651351d54
https://pubmed.ncbi.nlm.nih.gov/34590626
https://pubmed.ncbi.nlm.nih.gov/34590626
PKR activation by noncanonical ligands: a 5′-triphosphate requirement versus antisense contamination
Publikováno v:
RNA
Protein kinase RNA-activated (PKR) is an interferon-inducible kinase that is potently activated by long double-stranded RNA (dsRNA). In a previous study, we found that snoRNAs exhibit increased association with PKR in response to metabolic stress. Wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e998613305d9193a59d20c9efb1126c5
https://doi.org/10.1261/rna.071910.119
https://doi.org/10.1261/rna.071910.119