Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brenda L, Case"'
Autor:
Kaliappan Iyanar, Jessica D. Dietz, Graciela B. Arhancet, Horng-Chih Huang, Danny J. Garland, Marcia I. Heron, Silvia I. Pomposiello, Xiao Hu, Len F. Lee, Joe T. Collins, Scott S. Woodard, James Robert Blinn, Maria A. Payne, Brenda L. Case, Rhonda S. Woerndle
Publikováno v:
Journal of Medicinal Chemistry. 53:5970-5978
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9288e4053ed7e7f775bce265c4ec3184
https://doi.org/10.1021/jm100506y
https://doi.org/10.1021/jm100506y
Autor:
Barbara A. Schweitzer, Atli Thorarensen, Michael S. Davies, Steve R. Turner, Matthew James Pelc, James R. Kiefer, Brenda L. Case, Christie L. Funckes-Shippy, Jacqueline E. Day, Fengmei Hua, Dice Tom, William M. Abraham, Bradley E. Neal, John I. Trujillo, Joseph B. Moon, Blake Tanisha Danielle Rowe, Wei Huang, Craig D. Wegner, Dean Welsch, Chris P. Carron, Anup Zutshi, Bruce C. Hamper, Chad J. Warren, Rhonda S. Woerndle, Christine M. Kornmeier, Vickie M. Dilworth, Melanie L. Williams, Martin E. Dowty, Olson Kirk Lang, Melissa R. Radabaugh, Becky L. Hood, Jerry Z. Yang, Douglas C. Rohrer, Gina M. Jerome, Christine P. Bono
Publikováno v:
ACS Medicinal Chemistry Letters. 1:59-63
Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6559b7ee90a239bc2255e65f4dd700
https://doi.org/10.1021/ml900025z
https://doi.org/10.1021/ml900025z
Autor:
John J, Parlow, Mary W, Burney, Brenda L, Case, Thomas J, Girard, Kerri A, Hall, Peter K, Harris, Ronald R, Hiebsch, Rita M, Huff, Rhonda M, Lachance, Deborah A, Mischke, Stephen R, Rapp, Rhonda S, Woerndle, Michael D, Ennis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1388-1394
Efforts to refine the SAR of the piperazinyl-glutamate-pyridines for more potent analogs with improved pharmacokinetic profiles are described. Exploring substituted piperidines and other ring systems at the 4-pyridyl position led to compounds with im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa8e3393275c3b43dc35183d05b48db
https://doi.org/10.1016/j.bmcl.2009.12.110
https://doi.org/10.1016/j.bmcl.2009.12.110
Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation
Autor:
Kerri A. Hall, Rita M. Huff, Rhonda M. Lachance, Ennis Michael D, Rhonda S. Woerndle, Ronald R. Hiebsch, John J. Parlow, Stephen R. Rapp, Deborah A. Mischke, Brenda L. Case, Mary W. Burney, Thomas J. Girard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6148-6156
Piperazinyl-glutamate-pyrimidines were prepared with oxygen, nitrogen, and sulfur substitution at the 4-position of the pyrimidine leading to highly potent P2Y 12 antagonists. In particular, 4-substituted piperidine-4-pyrimidines provided compounds w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da90bff048b77255c54d7a7a094fdeb9
https://doi.org/10.1016/j.bmcl.2009.09.017
https://doi.org/10.1016/j.bmcl.2009.09.017
Publikováno v:
Tetrahedron. 55:6785-6796
A simple and efficient methodology for sequestering byproducts and excess starting reagent from the solution-phase Dess-Martin and Grieco-Dess-Martin periodinane mediated oxidation of primary or secondary alcohols to aldehydes or ketones is described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d90d4cf9beacc4a1fa6ea9281ea36396
https://doi.org/10.1016/s0040-4020(99)00342-7
https://doi.org/10.1016/s0040-4020(99)00342-7
Publikováno v:
ChemInform. 30
A simple and efficient methodology for sequestering byproducts and excess starting reagent from the solution-phase Dess-Martin and Grieco-Dess-Martin periodinane mediated oxidation of primary or secondary alcohols to aldehydes or ketones is described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8031692c782732f3426f30393cd320
https://doi.org/10.1002/chin.199938221
https://doi.org/10.1002/chin.199938221
Autor:
Olga V. Nemirovskiy, Mihir D. Parikh, Monica B. Norton, Jay M. Wendling, Michael S. Davies, Robert J. Mourey, Lakshman E. Rajagopalan, Toni A. Steiner, Ben S. Zweifel, Hideaki Shimada, Christine M. Kornmeier, Thomas P. Misko, Jaime L. Masferrer, Maria A. Payne, Larry E. Kahn, Stephen A. Kolodziej, Richard F Loeffler, Brenda L. Case
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 333(3)
Rho kinase, is the most widely studied downstream effector of the small Rho GTPase RhoA. Two Rho kinase isoforms have been described and are frequently referred to in the literature as ROCK1 and ROCK2. The RhoA-Rho kinase pathway has been implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a050f8933535407b1ce23153cb1f8587
https://pubmed.ncbi.nlm.nih.gov/20228155
https://pubmed.ncbi.nlm.nih.gov/20228155
Autor:
Michael S. South, John J. Parlow, James A Szalony, Rhonda M. Lachance, Susan G Panzer-Knodle, Jason D. Blom, Rhonda S Wood, Anita K. Salyers, Brenda L. Case, Nancy S. Nicholson, Osman D. Suleymanov
Publikováno v:
Thrombosis research. 112(3)
Introduction : Pharmacological treatment of deep vein thrombosis (DVT) in the future may target inhibitors of specific procoagulant proteins. This study used a non-human primate model to test the effect of PHA-798, a specific inhibitor of the tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3bc577e9fa53aae2358f8839f3cea9
https://pubmed.ncbi.nlm.nih.gov/14967414
https://pubmed.ncbi.nlm.nih.gov/14967414
Autor:
Graciela B. Arhancet, Scott S. Woodard, Kaliappan Iyanar, Brenda L. Case, Rhonda Woerndle, Jessica D. Dietz, Danny J. Garland, Joe T. Collins, Maria A. Payne, James R. Blinn, Silvia I. Pomposiello, Xiao Hu, Marcia I. Heron, Horng-Chih Huang, Len F. Lee
Publikováno v:
Journal of Medicinal Chemistry; Aug2010, Vol. 53 Issue 16, p5970-5978, 9p