Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Brenda K. Shell"'
Autor:
Johan Ericsson, John M. Greene, Kenneth C. Carter, Brenda K. Shell, D. Roxanne Duan, Charles Florence, Peter A. Edwards
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 9, Pp 1731-1739 (1998)
We report the nucleotide sequence of human geranylgeranyl diphosphate (GGPP) synthase cDNA isolated from a fetal heart library. The 2.5 kb cDNA encodes a protein of 34 kDa. The protein contains six domains that have been identified previously in many
Externí odkaz:
https://doaj.org/article/d2311d0917744433a4eae5e16c96697a
Autor:
Kenneth C. Carter, Charles Florence, Johan Ericsson, John M. Greene, D. Roxanne Duan, Brenda K. Shell, Peter A. Edwards
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 9, Pp 1731-1739 (1998)
We report the nucleotide sequence of human geranylgeranyl diphosphate (GGPP) synthase cDNA isolated from a fetal heart library. The 2.5 kb cDNA encodes a protein of 34 kDa. The protein contains six domains that have been identified previously in many
Publikováno v:
Biochemical and Biophysical Research Communications. 241:675-681
Two novel human genes encoding putative potassium channels, kH1 and kH2, were identified from a human fetal brain cDNA library. Sequence analysis showed that kH1 and kH2 are homologous to rat IK8 and rat K13, respectively. The kH1 encodes a polypepti
Autor:
Meena Augustus, P J Sciavolino, Wei Wu He, Brenda K. Shell, Kenneth C. Carter, D J Tindall, Cory Abate-Shen, P S Meissner, J Wing, D G Bostwick, P Hudson, R T Curtis, Edward P. Gelmann
Publikováno v:
Genomics. 43:69-77
We have isolated a prostate-specific gene (NKX3.1) in humans that is homologous to the Drosophila NK homeobox gene family. Northern blot analyses indicate that this gene is expressed at high levels in adult prostate and at a much lower level in testi
Publikováno v:
Genomics. 40:497-500
The chromosomal locations and the tissue expression patterns of the human transcriptional adaptors TADA2L and GCN5L2 have been determined. Northern blot analysis across a range of human tissues revealed that both the TADA2L and the GCN5L2 mRNAs are e
Autor:
Kenneth W. Kinzler, Kenneth C. Carter, Brenda K. Shell, Nicholas C. Nicolaides, Nickolas Papadopoulos, Bert Vogelstein
Publikováno v:
Genomics. 30:195-206
The hPMS2 gene (HGMW-approved symbol PMS2 ) encodes a mutL homolog that causes hereditary nonpolyposis colon cancer (HNPCC) when inherited in mutant form. We have here characterized the genomic structure of the hPMS2 gene to facilitate its analysis i
Autor:
Ying-Fei Wei, Peter Robins, Kenneth Carter, Keith Caldecott, Darryl J. C. Pappin, Guo-Liang Yu, Rui-Ping Wang, Brenda K. Shell, Rachel A. Nash, Primo Schär, Deborah E. Barnes, William A. Haseltine, Tomas Lindahl
Publikováno v:
Molecular and Cellular Biology. 15:3206-3216
Three distinct DNA ligases, I to III, have been found previously in mammalian cells, but a cloned cDNA has been identified only for DNA ligase I, an essential enzyme active in DNA replication. A short peptide sequence conserved close to the C terminu
Publikováno v:
DNA and cell biology. 17(6)
To establish immunologic autotolerance, self-reactive immature thymocytes are eliminated by negative selection during T-cell development in the thymus. Self-reactive clones undergo apoptosis after stimulation via the T-cell receptor (TCR). The proces
Publikováno v:
Nucleic acids research. 24(5)
The Escherichia coli AlkB protein is involved in protecting cells against mutation and cell death induced specifically by SN2-type alkylating agents such as methyl methanesulfonate (MMS). A human cDNA encoding a polypeptide homologous to E.coli AlkB
Autor:
Johan De Rooij, Maureen Biggerstaff, Rafael R. Ariza, Kenneth C. Carter, Elizabeth Evans, Ying Fei Wei, Mariska C. De Jong, Wouter de Laat, Nicolaas G. J. Jaspers, Suzanne Rademakers, Jonathan G. Moggs, Richard D. Wood, Jan H.J. Hoeijmakers, Brenda K. Shell, Anneke M. Sijbers
Publikováno v:
Cell. (5):811-822
Nucleotide excision repair, which is defective in xeroderma pigmentosum (XP), involves incision of a DNA strand on each side of a lesion. We isolated a human gene homologous to yeast Rad1 and found that it corrects the repair defects of XP group F as