Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brenda Janice Sanchez"'
Autor:
Derek T Hall, Takla Griss, Jennifer F Ma, Brenda Janice Sanchez, Jason Sadek, Anne Marie K Tremblay, Souad Mubaid, Amr Omer, Rebecca J Ford, Nathalie Bedard, Arnim Pause, Simon S Wing, Sergio Di Marco, Gregory R Steinberg, Russell G Jones, Imed‐Eddine Gallouzi
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 7, Pp n/a-n/a (2018)
Abstract Activation of AMPK has been associated with pro‐atrophic signaling in muscle. However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be ben
Externí odkaz:
https://doaj.org/article/a8b3c211642c4712934b7dbd386af718
Autor:
Sergio Di Marco, Jean-Philippe Leduc-Gaudet, Jennifer F. Ma, Imed-Eddine Gallouzi, Erzsébet Nagy Kovács, Brittany L. Phillips, Anne-Marie K. Tremblay, Patricia L. Hallauer, Kenneth E. M. Hastings, Dimitris L. Kontoyiannis, Souad Mubaid, Derek T Hall, Brenda Janice Sanchez, Sabah N. A. Hussain, Katherine E. Vest, Anita H. Corbett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
The master posttranscriptional regulator HuR promotes muscle fiber formation in cultured muscle cells. However, its impact on muscle physiology and function in vivo is still unclear. Here, we show that muscle-specific HuR knockout (muHuR-KO) mice hav
Autor:
Anita H. Corbett, Grace K. Pavlath, Ayan Banerjee, Sergio Di Marco, Brittany L. Phillips, Imed-Eddine Gallouzi, Brenda Janice Sanchez
Publikováno v:
Nucleic Acids Research
RNA processing is critical for proper spatial and temporal control of gene expression. The ubiquitous nuclear polyadenosine RNA binding protein, PABPN1, post-transcriptionally regulates multiple steps of gene expression. Mutations in the PABPN1 gene
Autor:
Derek T Hall, Anne-Marie K. Tremblay, Sergio Di Marco, Jennifer F. Ma, Brenda Janice Sanchez, Imed-Eddine Gallouzi
Publikováno v:
EMBO Molecular Medicine. 9:622-637
Cachexia is a debilitating syndrome characterized by involuntary muscle wasting that is triggered at the late stage of many cancers. While the multifactorial nature of this syndrome and the implication of cytokines such as IL‐6, IFNγ, and TNFα is
Autor:
Sergio Di Marco, Jennifer F. Ma, Virginie Dormoy-Raclet, Amr Omer, Scott A. Tenenbaum, Souad Mubaid, Brenda Janice Sanchez, Samantha Robinson, Imed-Eddine Gallouzi, Kholoud Ashour, Anne Cammas, Sridar V. Chittur, Xian J. Lian
Debilitating cancer-induced muscle wasting, a syndrome known as cachexia, is lethal. Here we report a posttranscriptional pathway involving the RNA-binding protein HuR as a key player in the onset of this syndrome. Under these conditions, HuR switche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba97dd8420a8f321305d36027391695
https://europepmc.org/articles/PMC6717253/
https://europepmc.org/articles/PMC6717253/
Destabilization of Nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fiber formation
Autor:
Matteo Giovarelli, Virginie Dormoy-Raclet, Brenda Janice Sanchez, Jennifer F. Ma, Stefania Millevoi, Anne Cammas, Roberto Gherzi, John B. Richardson, Isabel López de Silanes, Imed-Eddine Gallouzi, Kate van der Giessen, Carol J. Wilusz, Xian Jin Lian, Sergio Di Marco, Myriam Gorospe
Publikováno v:
Nature communications
HuR promotes myogenesis by stabilizing the MyoD, myogenin and p21 mRNAs during the fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA destabilizing activity, promotes the early steps of myogenesis by reducing the express
Autor:
Brenda Janice Sánchez, Anne-Marie K. Tremblay, Jean-Philippe Leduc-Gaudet, Derek T. Hall, Erzsebet Kovacs, Jennifer F. Ma, Souad Mubaid, Patricia L. Hallauer, Brittany L. Phillips, Katherine E. Vest, Anita H. Corbett, Dimitris L. Kontoyiannis, Sabah N. A. Hussain, Kenneth E. M. Hastings, Sergio Di Marco, Imed-Eddine Gallouzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mR
Externí odkaz:
https://doaj.org/article/abbd8d839dcd49f5a47e7010f27a777f