Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Brenda J Andrews"'
Autor:
Yuko Arita, Griffin Kim, Zhijian Li, Helena Friesen, Gina Turco, Rebecca Y Wang, Dale Climie, Matej Usaj, Manuel Hotz, Emily H Stoops, Anastasia Baryshnikova, Charles Boone, David Botstein, Brenda J Andrews, R Scott McIsaac
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 6, Pp 1-23 (2021)
Abstract The ability to switch a gene from off to on and monitor dynamic changes provides a powerful approach for probing gene function and elucidating causal regulatory relationships. Here, we developed and characterized YETI (Yeast Estradiol strain
Externí odkaz:
https://doaj.org/article/e823bfdfa6794a8b99835ae6fd0838ee
Autor:
Michelle M Conti, Julie M Ghizzoni, Ana Gil-Bona, Wen Wang, Michael Costanzo, Rui Li, Mackenzie J Flynn, Lihua Julie Zhu, Chad L Myers, Charles Boone, Brenda J Andrews, Jennifer A Benanti
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010349 (2022)
A network of transcription factors (TFs) coordinates transcription with cell cycle events in eukaryotes. Most TFs in the network are phosphorylated by cyclin-dependent kinase (CDK), which limits their activities during the cell cycle. Here, we invest
Externí odkaz:
https://doaj.org/article/ee09442a30bf4dfe8cda0546781b70c7
Autor:
Jolanda van Leeuwen, Carles Pons, Guihong Tan, Zi Yang Wang, Jing Hou, Jochen Weile, Marinella Gebbia, Wendy Liang, Ermira Shuteriqi, Zhijian Li, Maykel Lopes, Matej Ušaj, Andreia Dos Santos Lopes, Natascha van Lieshout, Chad L Myers, Frederick P Roth, Patrick Aloy, Brenda J Andrews, Charles Boone
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 9, Pp 1-24 (2020)
Abstract Essential genes tend to be highly conserved across eukaryotes, but, in some cases, their critical roles can be bypassed through genetic rewiring. From a systematic analysis of 728 different essential yeast genes, we discovered that 124 (17%)
Externí odkaz:
https://doaj.org/article/27e5a5f4f3414f1c97c8f31d1a196803
Autor:
Mojca Mattiazzi Usaj, Nil Sahin, Helena Friesen, Carles Pons, Matej Usaj, Myra Paz D Masinas, Ermira Shuteriqi, Aleksei Shkurin, Patrick Aloy, Quaid Morris, Charles Boone, Brenda J Andrews
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 2, Pp 1-27 (2020)
Abstract Our ability to understand the genotype‐to‐phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single‐cell level. To systematically assess cell‐to‐cell phenotypic variability, we combined auto
Externí odkaz:
https://doaj.org/article/7986b1484d9d4e6cac836c9b612e4d93
Autor:
Brenda J Andrews
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/8b88ef03d83845f08995322d26ea480e
Autor:
Mahfuzur Rahman, Maximilian Billmann, Michael Costanzo, Michael Aregger, Amy H Y Tong, Katherine Chan, Henry N Ward, Kevin R Brown, Brenda J Andrews, Charles Boone, Jason Moffat, Chad L Myers
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 5, Pp n/a-n/a (2021)
Abstract We present FLEX (Functional evaluation of experimental perturbations), a pipeline that leverages several functional annotation resources to establish reference standards for benchmarking human genome‐wide CRISPR screen data and methods for
Externí odkaz:
https://doaj.org/article/b77f0c4de34540ad85f7efa1a9046e4b
Autor:
Reiko Kintaka, Koji Makanae, Shotaro Namba, Hisaaki Kato, Keiji Kito, Shinsuke Ohnuki, Yoshikazu Ohya, Brenda J Andrews, Charles Boone, Hisao Moriya
Publikováno v:
eLife, Vol 9 (2020)
Overproduction (op) of proteins triggers cellular defects. One of the consequences of overproduction is the protein burden/cost, which is produced by an overloading of the protein synthesis process. However, the physiology of cells under a protein bu
Externí odkaz:
https://doaj.org/article/e6787edb0fe14313bbb3ee62e8ff839b
Autor:
Oren Z Kraus, Ben T Grys, Jimmy Ba, Yolanda Chong, Brendan J Frey, Charles Boone, Brenda J Andrews
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 4, Pp 1-15 (2017)
Abstract Existing computational pipelines for quantitative analysis of high‐content microscopy data rely on traditional machine learning approaches that fail to accurately classify more than a single dataset without substantial tuning and training,
Externí odkaz:
https://doaj.org/article/7d17f04c8f62472f87fec588070afc4e
Autor:
Alex X Lu, Yolanda T Chong, Ian Shen Hsu, Bob Strome, Louis-Francois Handfield, Oren Kraus, Brenda J Andrews, Alan M Moses
Publikováno v:
eLife, Vol 7 (2018)
The evaluation of protein localization changes on a systematic level is a powerful tool for understanding how cells respond to environmental, chemical, or genetic perturbations. To date, work in understanding these proteomic responses through high-th
Externí odkaz:
https://doaj.org/article/53a7eae98e7f4b198f6b9657f1119bc4
Autor:
Fan Yang, Song Sun, Guihong Tan, Michael Costanzo, David E Hill, Marc Vidal, Brenda J Andrews, Charles Boone, Frederick P Roth
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006779 (2017)
To better understand the health implications of personal genomes, we now face a largely unmet challenge to identify functional variants within disease-associated genes. Functional variants can be identified by trans-species complementation, e.g., by
Externí odkaz:
https://doaj.org/article/2f29d2a8d69541efa935142b9503e2ee