Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Brenda I. Gerwin"'
Publikováno v:
International Journal of Cancer. 83:564-570
Overexpression of the growth factor receptor ErbB-2/Her2/Neu has been implicated in the development of non-small-cell lung cancer. We have reported that the transformation of human lung epithelial cells by c-erbB-2 also requires an active ErbB-1 (EGF
Autor:
Karin Mattson, Harvey I. Pass, Kaija Linnainmaa, Brenda I. Gerwin, Lixin Xu, Susan Ungar, Barbara J. Flynn
Publikováno v:
Carcinogenesis. 20:773-783
Normal human mesothelial cells from individual donors were studied for susceptibility to asbestos-induction of apoptosis and generation of an extended lifespan population. Such populations were generated after death of the majority of cells and arose
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 275:L165-L171
A failure of normal apoptosis, often due to mutant p53, may contribute to the formation of a cancer and to its resistance to therapy. Mesothelioma, an asbestos-induced tumor, is highly resistant to therapy but generally expresses wild-type p53. We as
Publikováno v:
British Journal of Cancer
Over-expression of erbB-2 is associated with shortened survival of patients with lung adenocarcinomas. We demonstrated that human lung epithelial cells, overexpressing erbB-2, formed tumours in nude mice only when high levels of transforming growth f
Publikováno v:
Environmental Health Perspectives
Invariably mesothelioma is diagnosed late in the development of the disease when treatment is no longer effective. Therefore, a key to reducing the mortality rate of this neoplasm is knowledge of the general sequence of genetic events between initiat
Publikováno v:
British Journal of Cancer
Prior analysis of 20 human mesothelioma cell lines for p53 status revealed only two mutations and one p53 null cell line, although p53 expression was detected in most cell lines. In addition, mRNA and protein expression of the retinoblastoma gene pro
Autor:
David Zahra, Noel J. Whitaker, R. De Silva, Mary G. McMenamin, Roger R. Reddel, Curtis C. Harris, Yang Ke, E. M. Rogan, Emma L. Duncan, Brenda I. Gerwin
Publikováno v:
International Journal of Cancer. 61:199-205
Non-tumorigenic SV40-immortalized human cells may be transformed to tumorigenicity by activated oncogenes, but the molecular genetics of this process are still poorly understood. We describe here 4SV40-transformed bronchial epithelial (BE) cell lines
Autor:
Curtis C. Harris, Thea D. Tlsty, Jennifer Kispert, Janet H. Sanchez, Brenda I. Gerwin, Kathleen Forrester
Publikováno v:
Molecular Carcinogenesis. 11:34-41
Infection of an SV40 large-T antigen-"immortalized" human bronchial epithelial cell line with a Zip-v-Ha-ras retroviral vector resulted in a mass culture that was tumorigenic in athymic nude mice. A tumor cell line derived from passage of the mass cu
Autor:
Anne Van der Meeren, Brenda I. Gerwin, John F. Lechner, Christer Betsholtz, Michael B. Seddon
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 8:214-221
Overexpression of platelet-derived growth factor (PDGF)-A as well as PDGF-B chain mRNA has previously been reported in human mesothelioma cell lines. In this report, it has been established that the A but not the B chain protein is expressed at detec
Autor:
Helen K. Reddel, Roger R. Reddel, Anne Van der Meeren, Edward Gabrielson, Curtis C. Harris, Brenda I. Gerwin
Publikováno v:
Carcinogenesis. 13:1359-1363
To determine if asbestos exposure could contribute to mesothelial cell carcinogenesis by selection and/or expansion of an initiated cell population, we compared normal human pleural mesothelial cells to either human mesothelioma cell lines or mesothe