Výsledky vyhledávání - "Brenda G Hogue"

Akademický článek

Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection

Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-19 (2023)

Abstract SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐s

Externí odkaz: https://doaj.org/article/173774a4d3874632894de3a50c2ec7e5

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Akademický článek

Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide.

Autor: Arpan Deb, William A Johnson, Alexander P Kline, Boston J Scott, Lydia R Meador, Dustin Srinivas, Jose M Martin-Garcia, Katerina Dörner, Chad R Borges, Rajeev Misra, Brenda G Hogue, Petra Fromme, Tsafrir S Mor

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172529 (2017)

Viral protein U (Vpu) is a type-III integral membrane protein encoded by Human Immunodeficiency Virus-1 (HIV- 1). It is expressed in infected host cells and plays several roles in viral progeny escape from infected cells, including down-regulation of

Externí odkaz: https://doaj.org/article/b4bf8b971cc542fbb57eb2ed80c4af4c

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Akademický článek

Immunological Characterization of Plant-Based HIV-1 Gag/Dgp41 Virus-Like Particles.

Autor: Sarah A Kessans, Mark D Linhart, Lydia R Meador, Jacquelyn Kilbourne, Brenda G Hogue, Petra Fromme, Nobuyuki Matoba, Tsafrir S Mor

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151842 (2016)

It is widely anticipated that a prophylactic vaccine may be needed to control the HIV/AIDS epidemic worldwide. Despite over two decades of research, a vaccine against HIV-1 remains elusive, although a recent clinical trial has shown promising results

Externí odkaz: https://doaj.org/article/f4351c501c2b4ea6bbd95c4fc6a17706

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Akademický článek

Biophysical Characterization of a Vaccine Candidate against HIV-1: The Transmembrane and Membrane Proximal Domains of HIV-1 gp41 as a Maltose Binding Protein Fusion.

Autor: Zhen Gong, Jose M Martin-Garcia, Sasha M Daskalova, Felicia M Craciunescu, Lusheng Song, Katerina Dörner, Debra T Hansen, Jay-How Yang, Joshua LaBaer, Brenda G Hogue, Tsafrir S Mor, Petra Fromme

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0136507 (2015)

The membrane proximal region (MPR, residues 649-683) and transmembrane domain (TMD, residues 684-705) of the gp41 subunit of HIV-1's envelope protein are highly conserved and are important in viral mucosal transmission, virus attachment and membrane

Externí odkaz: https://doaj.org/article/917a8eca855a4257aace46c69202a36f

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Akademický článek

Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501YMA30 Strain of SARS-CoV-2

Autor: Karen V. Kibler, Mateusz Szczerba, Douglas Lake, Alexa J. Roeder, Masmudur Rahman, Brenda G. Hogue, Lok-Yin Roy Wong, Stanley Perlman, Yize Li, Bertram L. Jacobs

Publikováno v: Vaccines, Vol 10, Iss 8, p 1172 (2022)

The Omicron SARS-CoV-2 variant has been designated as a variant of concern because its spike protein is heavily mutated. In particular, the Omicron spike is mutated at five positions (K417, N440, E484, Q493, and N501) that have been associated with e

Externí odkaz: https://doaj.org/article/9b8ece6e86844cca8f4922d870287460

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Nuclear export inhibitor Selinexor targeting XPO1 enhances coronavirus replication

Autor: Masmudur M. Rahman, Bereket Estifanos, Honor L. Glenn, Karen Kibler, Yize Li, Bertram Jacobs, Grant McFadden, Brenda G. Hogue

Publikováno v: bioRxiv

Nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication. Thus, inhibiting XPO1-mediated nuclear export with sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd40cb2e8b3072a95b862ef87748eb5d
https://europepmc.org/articles/PMC9948980/

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Intranasal immunization with a vaccinia virus vaccine vector expressing pre-fusion stabilized SARS-CoV-2 spike fully protected mice against lethal challenge with the heavily mutated mouse-adapted SARS2-N501Y

Autor: Karen V, Kibler, Mateusz, Szczerba, Douglas, Lake, Alexa J, Roeder, Masmudur, Rahman, Brenda G, Hogue, Lok-Yin, Roy Wong, Stanley, Perlman, Yize, Li, Bertram L, Jacobs

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1

The Omicron SARS-CoV-2 variant has been designated a variant of concern because its spike protein is heavily mutated. In particular, Omicron spike is mutated at 5 positions (K417, N440, E484, Q493 and N501) that have been associated with escape from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8a60244e421301adb351647b0d2abb1c
https://pubmed.ncbi.nlm.nih.gov/35893821

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