Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brenda DeGray"'
Autor:
Zhou Han, Joseph Ueland, Dennis Hernandez, Vincent Vellucci, Brenda DeGray, Sandra Hartman-Neumann, Fiona McPhee, Nannan Zhou
Publikováno v:
Journal of Antimicrobial Chemotherapy. 71:3495-3505
OBJECTIVE Daclatasvir (DCV) is a pan-genotypic non-structural protein 5A (NS5A) inhibitor that is approved for treatment of hepatitis C virus (HCV) genotype (GT)1 and GT3 in the USA and GT1, GT3 and GT4 in Europe. We set out to examine the impact of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793a3e0bde2f9f656492ea4295f27795
https://doi.org/10.1093/jac/dkw336
https://doi.org/10.1093/jac/dkw336
Autor:
Barbara E. Ehrlich, Michael E. Hodsdon, Chengpeng Fan, Camille Keeler, Jennifer H. Benbow, Brenda DeGray, Elias Lolis, Taylor Mann
Publikováno v:
Journal of Biological Chemistry. 287:37907-37916
Peripheral neuropathy is one of the most severe and irreversible side effects caused by treatment from several chemotherapeutic drugs, including paclitaxel (Taxol®) and vincristine. Strategies are needed that inhibit this unwanted side effect withou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8399ab6cda68a2db0ce8691273542fb
https://doi.org/10.1074/jbc.m112.385070
https://doi.org/10.1074/jbc.m112.385070
Publikováno v:
Journal of Biological Chemistry. 286:34575-34582
Paclitaxel (Taxol) is one of the most effective treatment options for patients suffering from a variety of cancers. A major side effect seen in a high percentage of patients treated with paclitaxel is irreversible peripheral neuropathy. We previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88223c6b9788737def3efd85debc21ef
https://doi.org/10.1074/jbc.m111.265751
https://doi.org/10.1074/jbc.m111.265751
Publikováno v:
Journal of Molecular and Cellular Cardiology. 49:829-835
Paclitaxel (Taxol) is a microtubule-stabilizing compound that is used for cancer chemotherapy. However, Taxol administration is limited by serious side effects including cardiac arrhythmia, which cannot be explained by its microtubule-stabilizing eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a3150f11622672bc003a369ba1f48b
https://doi.org/10.1016/j.yjmcc.2010.08.018
https://doi.org/10.1016/j.yjmcc.2010.08.018
Publikováno v:
The Journal of Neuroscience. 25:2853-2864
Ca2+signals in neurons use specific temporal and spatial patterns to encode unambiguous information about crucial cellular functions. To understand the molecular basis for initiation and propagation of inositol 1,4,5-trisphosphate (InsP3)-mediated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256f0c2d6a70d94886d57792cd8db346
https://doi.org/10.1523/jneurosci.4313-04.2005
https://doi.org/10.1523/jneurosci.4313-04.2005
Publikováno v:
Journal of Biological Chemistry. 274:17518-17524
We investigated whether the renal brush border Na+/H+ exchanger NHE3 exists in assemblies with other proteins in native kidney membranes. To this end we generated monoclonal antibodies (mAbs) against affinity purified NHE3 protein complexes. Hybridom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db6e761b0de95f594a2fcd60fdf3d4f
https://doi.org/10.1074/jbc.274.25.17518
https://doi.org/10.1074/jbc.274.25.17518
Publikováno v:
Journal of Biological Chemistry. 273:12391-12396
Experimental data indicate that the relatively hydrophilic carboxyl-terminal domains of Na+-H+ exchangers mediate the regulation of transporter activity through interactions with cytoskeletal effectors. It has therefore been assumed that this entire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e38a4861c285b308a4f2c688a1a90f5
https://doi.org/10.1074/jbc.273.20.12391
https://doi.org/10.1074/jbc.273.20.12391
Autor:
Ewa Folta-Stogniew, Titus J. Boggon, Edward T. Petri, Jozefina Casuscelli, Brenda DeGray, Stefan Schmidt, Andjelka S. Ćelić, Barbara E. Ehrlich
Publikováno v:
American journal of physiology. Renal physiology. 297(5)
Autosomal dominant polycystic kidney disease (ADPKD) arises following mutations of either Pkd1 or Pkd2. The proteins these genes encode, polycystin-1 (PC1) and polycystin-2 (PC2), form a signaling complex using direct intermolecular interactions. Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32ebb279d6f85fea199f61c5ada29ee
https://pubmed.ncbi.nlm.nih.gov/19726544
https://pubmed.ncbi.nlm.nih.gov/19726544
Autor:
Klara Szigeti-Buck, Anurag Varshney, Yogendra Sharma, Christina Schlecker, Wolfgang Boehmerle, Brenda DeGray, Barbara E. Ehrlich, Andreas Jeromin
Regulation and dysregulation of intracellular calcium (Ca2+) signaling via the inositol 1,4,5-trisphosphate receptor (InsP3R) has been linked to many cellular processes and pathological conditions. In the present study, addition of neuronal calcium s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d5fd329354b3d0674dd11567065648
https://europepmc.org/articles/PMC1459068/
https://europepmc.org/articles/PMC1459068/
Autor:
Brenda DeGray, Eunkyung Lee, Pietro De Camilli, Per Uhlén, Markus R. Wenk, Barbara E. Ehrlich, Friedrich W. Johenning
Publikováno v:
The Biochemical journal. 382(Pt 2)
Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] plays an important physiological role as a precursor for the InsP3-mediated intracellular calcium (Ca2+) signalling cascade. It also regulates membrane trafficking, actin function and transmembran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5e5e91738a3e966f241df9f036aa13
https://pubmed.ncbi.nlm.nih.gov/15080793
https://pubmed.ncbi.nlm.nih.gov/15080793