Výsledky vyhledávání - "Brenda Cirincione"

Model-Based Evaluation of Exenatide Effects on the QT Interval in Healthy Subjects Following Continuous IV Infusion

Autor: Brenda Cirincione, Frank LaCreta, Donald E. Mager, Philip T. Sager

Publikováno v: The Journal of Clinical Pharmacology. 57:956-965

Investigation of the cardiovascular proarrhythmic potential of a new chemical entity is now an integral part of drug development. Studies suggest that meals and glycemic changes can influence QT intervals, and a semimechanistic model has been develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad9526cb63afc4da914c15983af4050c
https://doi.org/10.1002/jcph.882

Zobrazit plný text záznamu

Influence of Meals and Glycemic Changes on QT Interval Dynamics

Autor: Brenda Cirincione, Philip T. Sager, Donald E. Mager

Publikováno v: Journal of Clinical Pharmacology

Thorough QT/QTc studies have become an integral part of early drug development programs, with major clinical and regulatory implications. This analysis expands on existing pharmacodynamic models of QT interval analysis by incorporating the influence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474563682739b70a8e564f05950b58d9
https://doi.org/10.1002/jcph.933

Zobrazit plný text záznamu

Population pharmacokinetics of exenatide

Autor: Donald E. Mager, Brenda Cirincione

Publikováno v: British Journal of Clinical Pharmacology. 83:517-526

Aim The aim of the present analysis was to develop a core population pharmacokinetic model for the pharmacokinetic properties of immediate-release (IR) exenatide, which can be used in subsequent analyses of novel sustained-release formulations. Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92c83a4f1342a950ac51dbac419d8891
https://doi.org/10.1111/bcp.13135

Zobrazit plný text záznamu

The renal elimination of apixaban: the totality of data relating to the renal clearance of apixaban in patients with impaired renal function: response to Hellfritzschet al

Autor: Brenda Cirincione, Wonkyung Byon, Rebecca A. Boyd, Gregory Di Russo, Frank LaCreta

Publikováno v: Pharmacoepidemiology and Drug Safety. 26:603-605

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::077ecf41bcc7c4ee7804e238c751dc45
https://doi.org/10.1002/pds.4163

Zobrazit plný text záznamu

Population Pharmacokinetics of Apixaban in Subjects With Nonvalvular Atrial Fibrillation

Autor: Brenda Cirincione, Masayo Oishi, Charles Frost, Takayo Ueno, Xiaoli Wang, Frank LaCreta, Rebecca A. Boyd, Kenneth G. Kowalski, Jace Nielsen, Wonkyung Byon, Neelima Thanneer, Tarek A. Leil, Amit Roy

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology

This analysis describes the population pharmacokinetics (PPK) of apixaban in nonvalvular atrial fibrillation (NVAF) subjects, and quantifies the impact of intrinsic and extrinsic factors on exposure. The PPK model was developed using data from phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc141bc266a71739b681cffc579b2620
https://pubmed.ncbi.nlm.nih.gov/30259707

Zobrazit plný text záznamu

Plný text ve formátu HTML

Exenatide at therapeutic and supratherapeutic concentrations does not prolong the QT c interval in healthy subjects

Autor: Malcolm Mitchell, Leigh MacConell, Brenda Cirincione, Larry Z. Shen, Wenying Huang, Borje Darpo, Philip T. Sager, Lisa Porter, Jenny Han, Jaret Malloy, Christine Schulteis

Publikováno v: British Journal of Clinical Pharmacology

Aims Exenatide has been demonstrated to improve glycaemic control in patients with type 2 diabetes, with no effect on heart rate corrected QT (QTc) at therapeutic concentrations. This randomized, placebo- and positive-controlled, crossover, thorough

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d9deb0f38b2d017c90a2e8a9caa0c0
https://doi.org/10.1111/j.1365-2125.2012.04416.x

Zobrazit plný text záznamu