Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brenda C. Edwards"'
Autor:
Michael F. Hughes, Brenda C Edwards
Publikováno v:
Journal of toxicology and environmental health. Part A. 79(2)
Exposure to pyrethroid pesticides is a potential cause for concern. The objective of this study was to examine the in vivo dermal absorption of bifenthrin, deltamethrin, and permethrin in the rat. Dorsal hair on adult male Long-Evans rats was removed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5229e1376325bbd2914037914deec6
https://pubmed.ncbi.nlm.nih.gov/26817658
https://pubmed.ncbi.nlm.nih.gov/26817658
1. Pyrethroids are neurotoxic and parent pyrethroid appears to be toxic entity. This study evaluated the oral disposition and bioavailability of bifenthrin in the adult male Long-Evans rat. 2. In the disposition study, rats were administered bifenthr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669417308907a9061b4bf289df71290f
Autor:
Miroslav Styblo, Karen Herbin-Davis, Michael F. Hughes, David J. Thomas, Jesse Saunders, Brenda C. Edwards
Publikováno v:
Toxicology and Applied Pharmacology. 249:217-223
Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes formation of mono-, di-, and tri-methylated metabolites of inorganic arsenic. Distribution and retention of arsenic were compared in adult female As3mt knockout mice and wild-type C57B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2d0fd51302f7f6dd813a83a8a79c0a
https://doi.org/10.1016/j.taap.2010.09.017
https://doi.org/10.1016/j.taap.2010.09.017
Publikováno v:
Food and Chemical Toxicology. 39:1263-1270
Flame retardant chemicals may be used in furniture fabric in the future to reduce the flammability of the fabric. As a part of the process to evaluate the potential for exposure to these chemicals, this study examined the in vitro dermal absorption o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713d7c7bd8f2877a6e0c8e845c11e02f
https://doi.org/10.1016/s0278-6915(01)00074-6
https://doi.org/10.1016/s0278-6915(01)00074-6
Publikováno v:
Journal of Toxicology and Environmental Health. 45:279-290
The objective of this study was to investigate the in vitro dermal absorption of [14C]dimethylarsinic acid. This organic arsenical is used as a herbicide and is a product of the mammalian metabolism of inorganic arsenic. Discs of preclipped dorsal sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08f52ccf2d51241b3f6456ff0de9acb
https://doi.org/10.1080/15287399509531996
https://doi.org/10.1080/15287399509531996
Autor:
Michael F. Hughes, Brenda C. Edwards
Publikováno v:
Toxicology and applied pharmacology. 246(1-2)
Dermal exposure to pyrethroid pesticides can occur during manufacture and application. This study examined the in vitro dermal absorption of pyrethroids using rat and human skin. Dermatomed skin from adult male Long Evans rats or human cadavers was m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4111ad7540a456f602bb0bd9796901f1
https://pubmed.ncbi.nlm.nih.gov/20398685
https://pubmed.ncbi.nlm.nih.gov/20398685
Autor:
Surendra P. Shrivastava, Martha R. Sumler, Michael F. Hughes, Brenda C. Edwards, John H. Goodwin, Larry L. Hall, P. V. Shah, Henry L. Fisher
Publikováno v:
Journal of Toxicology and Environmental Health. 37:57-71
The purpose of this study was to investigate the dermal absorption of chemicals in different physical forms when applied to female F344 rats. Chemicals were applied either as a solid, aqueous paste, suspension, or dissolved in the volatile vehicle et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26560c5afc3307d4fd2744ab7458209d
https://doi.org/10.1080/15287399209531657
https://doi.org/10.1080/15287399209531657
Autor:
Michael F. Hughes, John T. Creed, David J. Thomas, X. Chris Le, Hua Naranmandura, Miroslav Styblo, Noboyu Maeda, Kevin M. Kubachka, Karen Herbin-Davis, Brenda C. Edwards, Zuzana Drobná
The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured human cells controls arsenic methylation phenotypes, suggesting a critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e797adfcd762b59dd8c70ba942b571a
Autor:
Michael F. Hughes, Luz M. Del Razo, Brenda C. Edwards, Carol T. Mitchell, Elaina M. Kenyon, David J. Thomas
Publikováno v:
Toxicology and applied pharmacology. 191(3)
Exposure to the human carcinogen inorganic arsenic (iAs) occurs daily. However, the disposition of arsenic after repeated exposure is not well known. This study examined the disposition of arsenic after repeated po administration of arsenate. Whole-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5ec6eb2457218171428e696bc814fc
https://pubmed.ncbi.nlm.nih.gov/13678653
https://pubmed.ncbi.nlm.nih.gov/13678653
Publikováno v:
Toxicology. 137(2)
Recent studies have suggested that polymorphisms in the methylation of inorganic arsenic (iAs) exist in animals and humans. Methylation of iAs is an important step in the elimination of arsenic. The objective of this study was to examine whether ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db26a81d83807d90d35cd8612eb4c67
https://pubmed.ncbi.nlm.nih.gov/10521146
https://pubmed.ncbi.nlm.nih.gov/10521146