Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brenda C Shields"'
Publikováno v:
eLife, Vol 5 (2016)
Clarifying gene expression in narrowly defined neuronal populations can provide insight into cellular identity, computation, and functionality. Here, we used next-generation RNA sequencing (RNA-seq) to produce a quantitative, whole genome characteriz
Externí odkaz:
https://doaj.org/article/bc00c371cd904ac88cdb99d060391d0a
Autor:
Hod Dana, Tsai-Wen Chen, Amy Hu, Brenda C Shields, Caiying Guo, Loren L Looger, Douglas S Kim, Karel Svoboda
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108697 (2014)
Genetically-encoded calcium indicators (GECIs) facilitate imaging activity of genetically defined neuronal populations in vivo. The high intracellular GECI concentrations required for in vivo imaging are usually achieved by viral gene transfer using
Externí odkaz:
https://doaj.org/article/84ee2ea372c043e3875da1b639043a5b
Autor:
Trevor J Wardill, Tsai-Wen Chen, Eric R Schreiter, Jeremy P Hasseman, Getahun Tsegaye, Benjamin F Fosque, Reza Behnam, Brenda C Shields, Melissa Ramirez, Bruce E Kimmel, Rex A Kerr, Vivek Jayaraman, Loren L Looger, Karel Svoboda, Douglas S Kim
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77728 (2013)
Fluorescent protein-based sensors for detecting neuronal activity have been developed largely based on non-neuronal screening systems. However, the dynamics of neuronal state variables (e.g., voltage, calcium, etc.) are typically very rapid compared
Externí odkaz:
https://doaj.org/article/260c05b0e92b4cd0a03c4417df7ccb10
Autor:
Brenda C. Shields, Haidun Yan, Shaun S.X. Lim, Sasha C. Burwell, Elizabeth A. Fleming, Celine M. Cammarata, Elizabeth W. Kahuno, Purav P. Vagadia, Marie H. Loughran, Lei Zhiquan, Mark E. McDonnell, Miranda L. Scalabrino, Mishek Thapa, Tammy M. Hawley, Allen B. Reitz, Gary E. Schiltz, Court Hull, Greg D. Field, Lindsey L. Glickfeld, Michael R. Tadross
SUMMARYCell-specific pharmaceutical technologies promise mechanistic insight into clinical drugs―those that treat, and often define, human disease. In particular,DART(drug acutely restricted by tethering) achieves genetically programmable control o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f6a4d1c5d75b1491bfae2f568e14d0c
https://doi.org/10.1101/2022.10.18.512779
https://doi.org/10.1101/2022.10.18.512779
Autor:
Brad A. Grueter, Kevin M. Manz, Carrie A. Grueter, Brenda C Shields, Benjamin C. Coleman, Michael R. Tadross
Publikováno v:
J Neurosci
The nucleus accumbens shell (NAcSh) receives extensive monoaminergic input from multiple midbrain structures. However, little is known how norepinephrine (NE) modulates NAc circuit dynamics. Using a dynamic electrophysiological approach with optogene
Autor:
Brett D. Mensh, Joshua T. Dudman, Jayaram Chandrashekar, Johan Winnubst, Chenghao Liu, James W Phillips, Wyatt Korff, Erina Hara, Andrew L. Lemire, Brenda C Shields, Lihua Wang, Anton Schulmann, Adam W. Hantman, Vera Valakh, Sacha B. Nelson
Publikováno v:
Nature neuroscience
The thalamus is the central communication hub of the forebrain and provides the cerebral cortex with inputs from sensory organs, subcortical systems and the cortex itself. Multiple thalamic regions send convergent information to each cortical region,
Publikováno v:
Journal of Neural Engineering. 19:024001
Objective. The micro-electrode array (MEA) is a cell-culture surface with integrated electrodes used for assays of electrically excitable cells and tissues. MEAs have been a workhorse in the study of neurons and myocytes, owing to the scalability and
Autor:
Max E. Joffe, James Maksymetz, Joseph R. Luschinger, Shalini Dogra, Anthony S. Ferranti, Deborah J. Luessen, Isabel M. Gallinger, Zixiu Xiang, Hannah Branthwaite, Patrick R. Melugin, Kellie M. Williford, Samuel W. Centanni, Brenda C. Shields, Craig W. Lindsley, Erin S. Calipari, Cody A. Siciliano, Colleen M. Niswender, Michael R. Tadross, Danny G. Winder, P. Jeffrey Conn
Publikováno v:
Neuron
Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited understanding of the molecular and experience-dependent mechanisms that regulate synaptic plasticity across PFC microcircuits. We discovered that mGlu(5) rece
Autor:
Brenda C. Shields, Jonathan B. Grimm, Eric R. Schreiter, Laurel M. Heckman, Luke D. Lavis, Mark A. Verdecia, Charles Kim
Publikováno v:
Angewandte Chemie (International Ed. in English)
Photolabile protecting groups (or “photocages”) enable precise spatiotemporal control of chemical functionality and facilitate advanced biological experiments. Extant photocages exhibit a simple input–output relationship, however, where applica
Autor:
Matthew G. Phillips, Johan Winnubst, Jayaram Chandrashekar, Mark S. Cembrowski, Brenda C. Shields, Salvatore F DiLisio, Erhan Bas, Nelson Spruston
Publikováno v:
Cell. 174(4)
The mammalian hippocampus, comprised of serially connected subfields, participates in diverse behavioral and cognitive functions. It has been postulated that parallel circuitry embedded within hippocampal subfields may underlie such functional divers