HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.

Autor: Brenda C O'Connell, Katie O'Callaghan, Bonnie Tillotson, Mark Douglas, Nafeeza Hafeez, Kip A West, Howard Stern, Janid A Ali, Paul Changelian, Christian C Fritz, Vito J Palombella, Karen McGovern, Jeffery L Kutok

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115228 (2014)

HSP90 inhibitors are currently undergoing clinical evaluation in combination with antimitotic drugs in non-small cell lung cancer (NSCLC), but little is known about the cellular effects of this novel drug combination. Therefore, we investigated the m

Externí odkaz: https://doaj.org/article/9d093119cf444dc3945b927b8fef1652

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

Autor: J. Wade Harper, Jennifer Svendsen, Stephen J. Elledge, Agata Smogorzewska, Mathew E. Sowa, Steven P. Gygi, Brenda C. O'Connell

Publikováno v: Cell. 138:63-77

Summary Structure-specific endonucleases mediate cleavage of DNA structures formed during repair of collapsed replication forks and double-strand breaks (DSBs). Here, we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63d93bcc0269da7393f60a8f77afa30
https://doi.org/10.1016/j.cell.2009.06.030

A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns

Autor: Ann F. Cheung, John M. Sedivy, Maria K. Mateyak, Brenda C. O'Connell, Carl P. Simkevich, Xiaojia Ren, Wanny Tam

Publikováno v: Journal of Biological Chemistry. 278:12563-12573

The myc proto-oncogenes encode transcriptional regulators whose inappropriate expression is correlated with a wide array of human malignancies. Up-regulation of Myc enforces growth, antagonizes cell cycle withdrawal and differentiation, and in some s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424e5d7bf72dc34fac4f467765b73681
https://doi.org/10.1074/jbc.m210462200

Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest

Autor: Javier León, Nuria Ferrandiz, Verónica Torrano, John M. Sedivy, Carlos Richard, M. Dolores Delgado, Juan C. Acosta, Gabriel Bretones, Rosa M. Blanco, Brenda C. O'Connell

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Acosta, J C, Ferrándiz, N, Bretones, G, Torrano, V, Blanco, R, Richard, C, O'Connell, B, Sedivy, J, Delgado, M D & León, J 2008, ' Myc Inhibits p27-Induced Erythroid Differentiation of Leukemia Cells by Repressing Erythroid Master Genes without Reversing p27-Mediated Cell Cycle Arrest ', Molecular and Cellular Biology, vol. 28, no. 24, pp. 7286-7295 . https://doi.org/10.1128/MCB.00752-08

Inhibition of differentiation has been proposed as an important mechanism for Myc-induced tumorigenesis, but the mechanisms involved are unclear. We have established a genetically defined differentiation model in human leukemia K562 cells by conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e94da7132ae808a1c614f11d27b6292
http://hdl.handle.net/10261/50201

Ubiquitin proteasome system (UPS): what can chromatin do for you?

Autor: J. Wade Harper, Brenda C. O'Connell

Publikováno v: Current opinion in cell biology. 19(2)

Cul4-Ddb1, a RING H2 ubiquitin ligase, plays an important role in many vital cellular processes including DNA replication, DNA repair and transcription. Recent research reveals strong links between Cul4-mediated signaling pathways and chromatin biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d002bf82361f9d0a44836386ae51999
https://pubmed.ncbi.nlm.nih.gov/17314036