Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Brenda Ames"'
Autor:
Jin Wang, Andrea Hall, Geoffrey W. Henson, Brenda Ames, Mohamed Aljarah, Andrea Brancale, Elena Gorovits, Arnaud Gilles, John Vernachio, Karolina Madela, Babita Ganguly, Stanley D. Chamberlain, Jerry Muhammad, Nicola Zonta, Joseph M. Patti, Jeff T. Hutchins, Christopher McGuigan, Alexander A. Kolykhalov
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4850-4854
We herein report a novel double pro-drug approach applied to the anti-HCV agent 2'-beta-C-methyl guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug moiety are combined to generate lipophilic prodrugs of the monophosphate of th
Autor:
Andrea Hall, Christopher McGuigan, K. Dawn Bryant, Babita Ganguly, Arnaud Gilles, Robin Walters, Jerry Muhammad, John Vernachio, Mohamed Aljarah, Nicholas Raja, Elena Gorovits, Geoffrey W. Henson, Jin Wang, Sabrina Holl, Damound Hunley, Brenda Ames, Alexander A. Kolykhalov, Stanley D. Chamberlain, Karolina Madela, Yule Liu, Sarah Jones, Jeff T. Hutchins
Publikováno v:
Journal of Medicinal Chemistry. 53:4949-4957
Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies. Nucleoside analogues with improved exposure, efficacy, and selectivity are recognized as likely key components of future HCV therapy. 2'-C-Methylgua
Autor:
John Vernachio, Jeff T. Hutchins, Andrea Hall, Paul Domanski, Elena Gorovits, Brenda Ames, Cathy Y. Chang, Joseph M. Patti, Peter J. Syribeys
Publikováno v:
Microbial Pathogenesis. 43:55-66
Enterococci are opportunistic pathogens known to cause numerous clinical infections and complications in humans. Adhesin-mediated binding to extracellular matrix (ECM) proteins of the host is thought to be a crucial step in the pathogenesis of these
Autor:
Joseph M. Patti, Bradley D. Prater, Brenda Ames, Yule Liu, John Vernachio, Elena Gorovits, Peter J. Syribeys
Publikováno v:
Infection and Immunity. 72:6237-6244
Staphylococcus capitis ( S. capitis ) has been implicated in a large proportion of coagulase-negative staphylococcal infections in very-low-birth-weight infants. To identify potential therapeutic targets, the S. capitis genome was probed for the pres
Autor:
Amy Schneider, Thuan P. Le, John Vernachio, Brenda Ames, Bradley D. Prater, Yin-Li Chai, Peter J. Syribeys, Joseph M. Patti, Jeff Robbins, Arnold S. Bayer
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:3400-3406
SA-IGIV is a human polyclonal immunoglobulin containing elevated levels of antibodies specific for the fibrinogen-binding MSCRAMM protein clumping factor A (ClfA). In vitro, SA-IGIV specifically recognized ClfA that was expressed on the surface ofSta
Autor:
Geoffrey W. Henson, Jin Wang, K. Dawn Bryant, Christopher McGuigan, Brenda Ames, Joseph M. Patti, Karen Williams, Alexander A. Kolykhalov, Yule Liu, Mohamed Aljarah, Elena Gorovits, Jeff T. Hutchins, Jerry Muhammad, Blair Bleiman, John Vernachio, Damound Hunley, Nicholas Raja, Andrea Hall, Karolina Madela, Arnaud Gilles, Babita Ganguly, C. Robin Walters, Stanley D. Chamberlain
Publikováno v:
Antimicrobial agents and chemotherapy. 55(5)
INX-08189 is an aryl-phosphoramidate of 6- O -methyl-2′- C -methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10 ± 6 nM against hepatitis C genotype 1b at 72 h. The inhibitory effect on viral r
Autor:
Dawn Bryant, Bradley D. Prater, Joseph M. Patti, Brenda Ames, Elena Gorovits, John Vernachio, Arnold S. Bayer, Peter J. Syribeys
A human donor-selected immunoglobulin G for intravenous injection (IGIV) product with elevated titers against the staphylococcal fibrinogen-binding MSCRAMM proteins ClfA and SdrG (INH-A21) was tested in vitro and in vivo. INH-A21 contained a signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c3de7a15a292d321875ce6b728e8af
https://europepmc.org/articles/PMC1366878/
https://europepmc.org/articles/PMC1366878/
Autor:
Christopher McGuigan, Arnaud Gilles, Karolina Madela, Mohamed Aljarah, Sabrina Holl, Sarah Jones, John Vernachio, Jeff Hutchins, Brenda Ames, K. Dawn Bryant, Elena Gorovits, Babita Ganguly, Damound Hunley, Andrea Hall, Alexander Kolykhalov, Yule Liu, Jerry Muhammad, Nicholas Raja, Robin Walters, Jin Wang
Publikováno v:
Journal of Medicinal Chemistry; Jul2010, Vol. 53 Issue 13, p4949-4957, 9p