Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brenda, Martino"'
Autor:
Brenda Martino, Diana L. Donnelly-Roberts, Jill M. Wetter, Marie E. Uchic, Kennan C. Marsh, Ahmed A. Hakeem, Sherry Nelson, Teodozyj Kolasa, Gin C. Hsieh, Odile F. El-Kouhen, Kathleen H. Mortell, Rohde Jeffrey J, Meena V. Patel, Ruth L. Martin, Marlon D. Cowart, Peter R. Hollingsworth, Marc A. Terranova, Andrew O. Stewart, Robert B. Moreland, and Jorge D. Brioni, Mark A. Matulenko, Loan N. Miller, Gary A. Gintant, James P. Sullivan, Marian T. Namovic, John F. Darbyshire, Renjie Chang, Masaki Nakane
Publikováno v:
Journal of Medicinal Chemistry. 49:7450-7465
The goal of this study was to identify a structurally distinct D(4)-selective agonist with superior oral bioavailability to our first-generation clinical candidate 1a (ABT-724) for the potential treatment of erectile dysfunction. Arylpiperazines such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f481cffca5c5c281238800552907e71e
https://doi.org/10.1021/jm060662k
https://doi.org/10.1021/jm060662k
Autor:
Michael W. Decker, Arthur L. Nikkel, Jorge D. Brioni, Stephani Otte, Brenda Martino, Robert B. Moreland, Pramila Bhatia, Robert S. Bitner, Andrew O. Stewart, Eve H. Barlow
Publikováno v:
Neuropharmacology. 50:521-531
The dopamine D4 receptor has been investigated for its potential role in several CNS disorders, notably schizophrenia and more recently, erectile dysfunction. Whereas studies have investigated dopamine D4 receptor-mediated signaling in vitro, there h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46926044ff02d556743304a9ea6d8c80
https://doi.org/10.1016/j.neuropharm.2005.10.009
https://doi.org/10.1016/j.neuropharm.2005.10.009
Autor:
Prisca Honore, Brenda Martino, Arthur L. Nikkel, Michael W. Decker, Chang Z. Zhu, Robert S. Bitner
Publikováno v:
European Journal of Pharmacology. 531:108-117
Previous studies have demonstrated that Fos-like immunoreactivity is increased in spinal dorsal horn neurons in several pain models, and have suggested that Fos-like immunoreactivity could be used as a marker of neurons activated by painful stimulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37749e161f84e8730ce99a251ce06efe
https://doi.org/10.1016/j.ejphar.2005.12.019
https://doi.org/10.1016/j.ejphar.2005.12.019
Autor:
Joseph P. Mikusa, Peter R. Hollingsworth, Robert B. Moreland, Brenda Martino, R. Scott Bitner, Gin C. Hsieh
Publikováno v:
Pharmacology Biochemistry and Behavior. 81:797-804
A series of in vivo studies in a conscious rat model was conducted to investigate the role of oxytocinergic and dopaminergic neurotransmission in the central regulation of penile erection. Oxytocin, when administrated either intracerebroventricularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400ff4706ac8eab81e0b9a82a146ed8e
https://doi.org/10.1016/j.pbb.2005.06.003
https://doi.org/10.1016/j.pbb.2005.06.003
Autor:
Arthur L. Nikkel, Brenda Martino, Stella Markosyan, Robert S. Bitner, Rodrigo Medeiros, Achim Moeller, Jill-Desiree Brederson
Publikováno v:
Neuropharmacology. 63(4)
Calcium-mediated pathologic activation of the cysteine protease calpain has been linked to neurodegenerative disorders such as Alzheimer's disease (AD) through the cleavage of proteolytic substrates that negatively affect neuronal function. Hyperphos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8581b10f0a526a4434b8663d00af201d
https://pubmed.ncbi.nlm.nih.gov/22613839
https://pubmed.ncbi.nlm.nih.gov/22613839
Autor:
Stella Markosyan, Michael W. Decker, Robert S. Bitner, James P. Sullivan, Hans Schoemaker, Achim Moeller, Alfred Hahn, Brenda Martino, Arthur L. Nikkel
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea1da4dc219b8d8999691cda66b7a9b1
https://doi.org/10.1016/j.jalz.2008.05.1456
https://doi.org/10.1016/j.jalz.2008.05.1456
Autor:
Teodozyj Kolasa, Kathleen Mortell, Renje Chang, Jorge D. Brioni, Meena V. Patel, Marc A. Terranova, Brenda Martino, Masaki Nakane, Robert B. Moreland, Odile F. El Kouhen, Andrew O. Stewart, Marian T. Namovic, Pramila Bhatia, Mark A. Matulenko, Diana L. Donnelly-Roberts, Peter R. Hollingsworth, Marie E. Uchic, Loan N. Miller, Kennan C. Marsh, Gin C. Hsieh, Rodger F. Henry, Ahmed A. Hakeem, Jill M. Wetter
Publikováno v:
Journal of medicinal chemistry. 49(17)
A new series of dopamine D4 receptor agonists, 1-aryl-3-(4-pyridinepiperazin-1-yl)propanone oximes, was designed through the modification of known dopamine D4 receptor agonist PD 168077. Replacement of the amide group with a methylene-oxime moiety pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e50ed5e8c7b8542a2808ed29eccec91
https://pubmed.ncbi.nlm.nih.gov/16913699
https://pubmed.ncbi.nlm.nih.gov/16913699
Autor:
Katharine L. Chu, Arthur L. Nikkel, Michael F. Jarvis, Robert S. Bitner, Rachid El Kouhen, Edward C. Burgard, Brenda Martino, Connie R. Faltynek, Ping Han, Steve McGaraughty
Publikováno v:
Journal of neurophysiology. 90(4)
It is well established that the vanilloid receptor, VR1, is an important peripheral mediator of nociception. VR1 receptors are also located in several brain regions, yet it is uncertain whether these supraspinal VR1 receptors have any influence on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c89f1fbc9b8e98df20581bb321863ed
https://pubmed.ncbi.nlm.nih.gov/12815018
https://pubmed.ncbi.nlm.nih.gov/12815018
Autor:
C, Hsieh Gin, R, Hollingsworth Peter, Brenda, Martino, Renjie, Chang, A, Terranova Marc, B, O'Neill Alyssa, J, Lynch James, B, Moreland Robert, L, Donnelly-Roberts Diana, Teodozyi, Kolasa, P, Mikusa Joseph, M, McVey Jill, C, Marsh Kennan, P, Sullivan James, D, Brioni Jorge
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; January 2004, Vol. 308 Issue: 1 p330-8, 9p