Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Brenda, Lilly"'
Autor:
Isaac Stanberry, David Cunningham, Shiqiao Ye, Matthew Alonzo, Ming-Tao Zhao, Vidu Garg, Brenda Lilly
Publikováno v:
Stem Cell Research, Vol 72, Iss , Pp 103213- (2023)
Alagille syndrome (ALGS) is a multisystem disease with high variability in clinical features. ALGS is predominantly caused by pathogenic variants in the Notch ligand JAG1. An iPSC line, NCHi011-A, was generated from a ALGS patient with complex cardia
Externí odkaz:
https://doaj.org/article/76446d6f621a40738f84a8d0537f9766
Autor:
David Cunningham, Isaac Stanberry, Shiqiao Ye, Matthew Alonzo, Ming-Tao Zhao, Vidu Garg, Brenda Lilly
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103177- (2023)
Alagille syndrome (ALGS) is an autosomal dominant disease affecting the liver, heart and other organs with high variability. About 95% of ALGS cases are associated with pathogenic variants in JAG1, encoding the Jagged1 ligand that binds to Notch rece
Externí odkaz:
https://doaj.org/article/e6ae087feb1f4ef8823214d3d75727ed
MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways
Autor:
Dwitiya Sawant, Brenda Lilly
Publikováno v:
Vascular Biology, Vol 2, Iss 1, Pp 115-128 (2020)
miRNAs are small regulatory RNAs which govern gene expression post-transcriptionally by primarily binding to the 3'-UTR of mRNA target genes. miR-145 is a well-studied miRNA that has been implicated in controlling a range of biological processes. miR
Externí odkaz:
https://doaj.org/article/85f1933b6a9d49198679a26e61370d3c
Autor:
Shelby Thomas, Sathiyanarayanan Manivannan, Dwitiya Sawant, Karthik M. Kodigepalli, Vidu Garg, Simon J. Conway, Brenda Lilly
Publikováno v:
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Abstract Background Both downregulation and elevation of microRNA miR‐145 has been linked to an array of cardiopulmonary phenotypes, and a host of studies suggest that it is an important contributor in governing the differentiation of cardiac and v
Externí odkaz:
https://doaj.org/article/58925ac48bdd40b1b4e257d816ec05bc
Autor:
Randa M. Breikaa, Brenda Lilly
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry
Externí odkaz:
https://doaj.org/article/718bd7933cc441738ebf7ff67e521951
Autor:
Patricia E. McCallinhart, Lauren A. Biwer, Olivia E. Clark, Brant E. Isakson, Brenda Lilly, Aaron J. Trask
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
RationaleMyoendothelial junctions (MEJs) within the fenestrae of the internal elastic lamina (IEL) are critical sites that allow for endothelial cell (EC) - vascular smooth muscle cell (VSMC) contact and communication. Vascular Notch signaling is a c
Externí odkaz:
https://doaj.org/article/0939308b340248e0811fa1ed02c88730
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 2, Iss 1, Pp 17-30 (2015)
Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV) and aortopa
Externí odkaz:
https://doaj.org/article/02c504b9cb0e4911881404bfaef3261c
Autor:
Jaspreet Sachdeva, Advitiya Mahajan, Jeeyun Cheng, Jeremy T Baeten, Brenda Lilly, Helena Kuivaniemi, Chetan P Hans
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178538 (2017)
Infiltration of macrophages and apoptosis of vascular smooth muscle cells (VSMCs) promote the development of abdominal aortic aneurysm (AAA). Previously, we demonstrated that global Notch1 deficiency prevents the formation of AAA in a mouse model. He
Externí odkaz:
https://doaj.org/article/8f82fdc5d96d4d0b8fbac9c98c4a5b8f
Autor:
Randa M. Breikaa, Kimberly Denman, Yukie Ueyama, Patricia E. McCallinhart, Aiman Q. Khan, Gunjan Agarwal, Aaron J. Trask, Vidu Garg, Brenda Lilly
Publikováno v:
Vascular pharmacology. 145
Notch signaling is an evolutionarily conserved pathway that functions via direct cell-cell contact. The Notch ligand Jagged1 (Jag1) has been extensively studied in vascular development, particularly for its role in smooth muscle cell maturation. Endo
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 6, Iss 2, p 24 (2019)
Mammalian Kiaa1211 and Kiaa1211-like are a homologous pair of uncharacterized, highly conserved genes cloned from fetal and adult brain cDNA libraries. Herein we map the in utero spatiotemporal expression of mKiaa1211 and mKiaa1211L mRNA and their ex
Externí odkaz:
https://doaj.org/article/d48d321398134129bc439b3337287e89