Biochemical and crystallographic studies of L,D-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate.

Autor: de Munnik M; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, UK., Lang PA; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, UK., Calvopiña K; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, UK., Rabe P; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, UK., Brem J; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, UK.; Enzymology and Applied Biocatalysis Research Center, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, Romania., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk.

Publikováno v: Communications biology [Commun Biol] 2024 Sep 18; Vol. 7 (1), pp. 1173. Date of Electronic Publication: 2024 Sep 18.

Bioaccesibilidad in vitro y concentraciones totales de minerales esenciales en carne de dorado (Salminus brasiliensis) crudo y cocido. (Spanish)

Autor: Trulls, H. E., Ortiz, M. L., Picot, J. A., Zach, A., Brem, J. C.

Publikováno v: Revista Veterinaria; 2023, Vol. 34 Issue 2, p111-116, 6p

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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.

Autor: Brem J; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. jurgen.brem@chem.ox.ac.uk., Panduwawala T; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Hansen JU; Statens Serum Institut, Copenhagen, Denmark., Hewitt J; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Liepins E; Latvian Institute of Organic Synthesis, Riga, Latvia., Donets P; Latvian Institute of Organic Synthesis, Riga, Latvia., Espina L; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Farley AJM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Shubin K; Latvian Institute of Organic Synthesis, Riga, Latvia., Campillos GG; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Kiuru P; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Shishodia S; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Krahn D; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Leśniak RK; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Schmidt Adrian J; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Calvopiña K; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Turrientes MC; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., Kavanagh ME; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Lubriks D; Latvian Institute of Organic Synthesis, Riga, Latvia., Hinchliffe P; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Langley GW; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Charles River Laboratories, Saffron Walden, UK., Aboklaish AF; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Eneroth A; Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden., Backlund M; Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden., Baran AG; Latvian Institute of Organic Synthesis, Riga, Latvia., Nielsen EI; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Speake M; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Kuka J; Latvian Institute of Organic Synthesis, Riga, Latvia., Robinson J; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Grinberga S; Latvian Institute of Organic Synthesis, Riga, Latvia., Robinson L; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., McDonough MA; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Rydzik AM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Research and Early Development, Respiratory & Immunology, AstraZeneca, Mölndal, Sweden., Leissing TM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Jimenez-Castellanos JC; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.; Chemical Biology of Antibiotics, Centre for Infection & Immunity (CIIL), Pasteur Institute, INSERM U1019 - CNRS UMR 9017, Lille, France., Avison MB; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Da Silva Pinto S; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Pannifer AD; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Martjuga M; Latvian Institute of Organic Synthesis, Riga, Latvia., Widlake E; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Priede M; Latvian Institute of Organic Synthesis, Riga, Latvia., Hopkins Navratilova I; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Gniadkowski M; Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland., Belfrage AK; Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden., Brandt P; Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden.; Beactica Therapeutics AB, Uppsala, Sweden., Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Bacque E; Evotec Infectious Diseases Lyon, Marcy l'Etoile, France., Page MGP; Jacobs University Bremen gGmbH, Bremen, Germany., Björkling F; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Tyrrell JM; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK.; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Spencer J; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Lang PA; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Baranczewski P; Department of Pharmacy, SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics Facility, Uppsala University, Uppsala, Sweden., Cantón R; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., McElroy SP; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Jones PS; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Baquero F; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., Suna E; Latvian Institute of Organic Synthesis, Riga, Latvia., Morrison A; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Walsh TR; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Schofield CJ; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk.

Publikováno v: Nature chemistry [Nat Chem] 2022 Jan; Vol. 14 (1), pp. 15-24. Date of Electronic Publication: 2021 Dec 13.

A dual covalent binder for labelling and inhibiting serine and metallo-carbapenemases.

Autor: Chen C; Department of Forestry Chemical Engineering, Shaanxi Key Laboratory of Economic Plant Resources Development and Utilization, Forestry College, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China. cchen@nwafu.edu.cn., Xu Y; Key Laboratory Synthetic and Natural Functional Molecular Chemistry of Ministry of Education, Chemical Biology Innovation Laboratory, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, P. R. China. kwyang@nwu.edu.cn., Oelschlaeger P; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona 91766, California, USA., Brem J; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.; Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford OX1 3TA, UK.; Janssen Research & Development, Janssen Pharmaceuticals, Beerse B-2340, Belgium., Liu L; Key Laboratory Synthetic and Natural Functional Molecular Chemistry of Ministry of Education, Chemical Biology Innovation Laboratory, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, P. R. China. kwyang@nwu.edu.cn., Wang D; Department of Forestry Chemical Engineering, Shaanxi Key Laboratory of Economic Plant Resources Development and Utilization, Forestry College, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China. cchen@nwafu.edu.cn., Sun H; Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China., Yang KW; Key Laboratory Synthetic and Natural Functional Molecular Chemistry of Ministry of Education, Chemical Biology Innovation Laboratory, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, P. R. China. kwyang@nwu.edu.cn.

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Jul 25; Vol. 59 (60), pp. 9227-9230. Date of Electronic Publication: 2023 Jul 25.