Neuroinflammation in Alzheimer disease.

Autor: Heneka MT; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette/Belvaux, Luxembourg. michael.heneka@uni.lu., van der Flier WM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands., Jessen F; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Hoozemanns J; Department of Pathology, Amsterdam Neuroscience, Amsterdam University Medical Centre, Amsterdam, The Netherlands., Thal DR; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.; Laboratory for Neuropathology, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Laboratory for Neuropathology, Department of Imaging and Pathology, Leuven Brain Institute (LBI), Leuven, Belgium., Boche D; Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Teunissen C; Department of Laboratory Medicine, VUMC Amsterdam, Amsterdam, The Netherlands., Zetterberg H; Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden., Jacobs AH; European Institute for Molecular Imaging, University of Münster, Münster, Germany., Edison P; Division of Neurology, Department of Brain Sciences, Imperial College London, London, UK., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.; Cluster of Excellence Cellular Stress Response in Aging-associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Cruchaga C; Department of Psychiatry, Washington School of Medicine in St. Louis, St. Louis, MO, USA., Lambert JC; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France., Laza AR; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain., Sanchez-Mut JV; Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Alicante, Spain., Fischer A; Clinic for Psychiatry and Psychotherapy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.; Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Centre for Neurodegenerative Disease (DZNE), Göttingen, Germany., Castro-Gomez S; Center for Neurology, Clinic of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany.; Institute of Physiology II, University Hospital Bonn, University of Bonn, Bonn, Germany.; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany., Stein TD; Boston University Alzheimer's Disease Research Center and CTE Center, Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Kleineidam L; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurodegenerative Disease and Geriatric Psychiatry, University Hospital Bonn, University of Bonn, Bonn, Germany., Wagner M; Department of Neurodegenerative Disease and Geriatric Psychiatry, University Hospital Bonn, University of Bonn, Bonn, Germany., Neher JJ; Biomedical Center Munich, Biochemistry, Medical Faculty, LMU Munich, Munich, Germany.; Neuroimmunology and Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Cunningham C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, Dublin, Ireland.; Trinity College Institute of Neuroscience (TCIN), Trinity College Dublin, Dublin, Ireland., Singhrao SK; Brain and Behaviour Centre, Faculty of Clinical and Biomedical Sciences, School of Dentistry, University of Central Lancashire, Preston, UK., Prinz M; Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.; Signalling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Glass CK; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Schlachetzki JCM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Butovsky O; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kleemann K; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., De Jaeger PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Scheiblich H; Center for Neurology, Clinic of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany., Brown GC; Deparment of Biochemistry, University of Cambridge, Cambridge, UK., Landreth G; School of Medicine, Indiana University, Indianapolis, IN, USA., Moutinho M; School of Medicine, Indiana University, Indianapolis, IN, USA., Grutzendler J; Department of Neurology, Yale School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA., Gomez-Nicola D; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., McManus RM; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Andreasson K; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Ising C; Cluster of Excellence Cellular Stress Response in Aging-associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Karabag D; Cluster of Excellence Cellular Stress Response in Aging-associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Baker DJ; Department of Paediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Liddelow SA; Neuroscience Institute, NYU Grossman School of Medicine, New York City, NY, USA.; Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York City, NY, USA.; Department of Ophthalmology, NYU Grossman School of Medicine, New York City, NY, USA., Verkhratsky A; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Tansey M; College of Medicine, University of Florida, Gainsville, FL, USA., Monsonego A; Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Aigner L; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria., Dorothée G; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine (CRSA), Hôpital Saint-Antoine, Paris, France., Nave KA; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Simons M; Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany., Constantin G; Section of General Pathology, Department of Medicine, University of Verona, Verona, Italy., Rosenzweig N; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Pascual A; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Petzold GC; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Vascular Neurology, University of Bonn, Bonn, Germany., Kipnis J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA., Venegas C; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette/Belvaux, Luxembourg.; Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain.; Instituto Biosanitario de Granada (ibs.Granada), Granada, Spain., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Walter J; Center of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany., Tenner AJ; Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, USA.; Department of Neurobiology and Behaviour, University of California Irvine, Irvine, CA, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA., O'Banion MK; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.; Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA., Steinert JR; Faculty of Medicine and Health Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Feinstein DL; Department of NeuroAnesthesia, University of Illinois at Chicago, Chicago, IL, USA., Sastre M; Department of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK., Bhaskar K; Department of Molecular Genetics & Microbiology and Neurology, University of New Mexico, Albuquerque, NM, USA., Hong S; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Schafer DP; Department of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Golde T; Department of Pharmacology and Chemical Biology, Emory Center for Neurodegenerative Disease, Emory University, Atlanta, GA, USA.; Department of Neurology, Emory Center for Neurodegenerative Disease, Emory University, Atlanta, GA, USA., Ransohoff RM; Third Rock Ventures, Boston, MA, USA., Morgan D; Department of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA., Breitner J; Department of Psychiatry, McGill University Faculty of Medicine, Montreal, Québec, Canada., Mancuso R; Microglia and Inflammation in Neurological Disorders (MIND) Lab, VIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Riechers SP; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette/Belvaux, Luxembourg.

Publikováno v: Nature reviews. Immunology [Nat Rev Immunol] 2024 Dec 09. Date of Electronic Publication: 2024 Dec 09.

How Do Modifiable Risk Factors Affect Alzheimer's Disease Pathology or Mitigate Its Effect on Clinical Symptom Expression?

Autor: Ourry V; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada. Electronic address: valentin.ourry@gmail.com., Binette AP; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada; Clinical Memory Research Unit, Department of Clinical Sciences, Lunds Universitet, Malmö, Sweden., St-Onge F; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada; Integrated Program in Neuroscience, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Strikwerda-Brown C; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada; School of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia., Chagnot A; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom., Poirier J; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada., Breitner J; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada., Arenaza-Urquijo EM; Environment and Health over the Lifecourse Programme, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Rabin JS; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Harquail Centre for Neuromodulation, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada; Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada., Buckley R; Melbourne School of Psychological Sciences University of Melbourne, Parkville, Victoria, Australia; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts., Gonneaud J; Normandie University, UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging of Neurological Disorders,' Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Caen, France., Marchant NL; Division of Psychiatry, University College London, London, United Kingdom., Villeneuve S; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. Electronic address: sylvia.villeneuve@mcgill.ca.

Publikováno v: Biological psychiatry [Biol Psychiatry] 2024 Jun 01; Vol. 95 (11), pp. 1006-1019. Date of Electronic Publication: 2023 Sep 07.

Contactin 5 and Apolipoproteins Interplay in Alzheimer's Disease.

Autor: Dauar MT; Douglas Mental Health University Institute, Montréal, Canada.; Centre for the Studies in the Prevention of Alzheimer's Disease, Montréal, Canada.; McGill University, Montreal, Canada.; CAPES Foundation, Ministry of Education of Brazil, Brasília, Brazil., Picard C; Douglas Mental Health University Institute, Montréal, Canada.; Centre for the Studies in the Prevention of Alzheimer's Disease, Montréal, Canada., Labonté A; Douglas Mental Health University Institute, Montréal, Canada.; Centre for the Studies in the Prevention of Alzheimer's Disease, Montréal, Canada., Breitner J; Douglas Mental Health University Institute, Montréal, Canada.; Centre for the Studies in the Prevention of Alzheimer's Disease, Montréal, Canada.; McGill University, Montreal, Canada.; Department of Psychiatry, McGill University, Montreal, Canada., Rosa-Neto P; McGill University, Montreal, Canada.; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Verdun, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada., Villeneuve S; Douglas Mental Health University Institute, Montréal, Canada.; Centre for the Studies in the Prevention of Alzheimer's Disease, Montréal, Canada.; McGill University, Montreal, Canada.; Department of Psychiatry, McGill University, Montreal, Canada., Poirier J; Douglas Mental Health University Institute, Montréal, Canada.; Centre for the Studies in the Prevention of Alzheimer's Disease, Montréal, Canada.; McGill University, Montreal, Canada.; Department of Psychiatry, McGill University, Montreal, Canada.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 98 (4), pp. 1361-1375.

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