In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells

Autor: Wosikowski, K., Biedermann, E., Rattel, B., Breiter, N., Jank, P., Löser, R., Gerrit Jansen, Peters, G. J.

Publikováno v: Wosikowski, K, Biedermann, E, Rattel, B, Breiter, N, Jank, P, Löser, R, Jansen, G & Peters, G J 2003, ' In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells ', Clinical Cancer Research, vol. 9, no. 5, pp. 1917-26 .
Scopus-Elsevier
Clinical Cancer Research, 9(5), 1917-26. American Association for Cancer Research Inc.

To avoid systemic toxicity of the cytotoxic drug methotrexate (MTX) and to improve tumor selectivity, MTX was bound to human serum albumin (HSA) as a drug carrier. To understand more about the mechanism of action of MTX conjugated to HSA (MTX-HSA), t

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https://research.vumc.nl/en/publications/a86959bc-0a01-46f3-b8b0-025d8083d87e

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Direct radiograpical high magnification mammography using a new microfocus tube. Experimental analysis of the resolution and radiation exposure.

Autor: Post, Karin, Hermann, K.-P., Funke, M., Hundertmark, C., Breiter, N., Grabbe, E.

Publikováno v: Der Radiologe; Aug1997, Vol. 37 Issue 8, p604-609, 6p

Polyethylene Glycol Conjugates of Methotrexate Varying in Their Molecular Weight from MW 750 to MW 40000:  Synthesis, Characterization, and Structure−Activity Relationships in Vitro and in Vivo

Autor: Riebeseel, K., Biedermann, E., Loser, R., Breiter, N., Hanselmann, R., Mulhaupt, R., Unger, C., Kratz, F.

Publikováno v: Bioconjugate Chemistry; July 2002, Vol. 13 Issue: 4 p773-785, 13p