Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Bree B Aldridge"'
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006774 (2019)
Drug combinations are a promising approach to achieve high efficacy at low doses and to overcome resistance. Drug combinations are especially useful when drugs cannot achieve effectiveness at tolerable doses, as occurs in cancer and tuberculosis (TB)
Externí odkaz:
https://doaj.org/article/f8fab638529b4dbc98c9eb873dab8b44
Autor:
Katherine M Mann, Deborah L Huang, Anna J Hooppaw, Michelle M Logsdon, Kirill Richardson, Hark Joon Lee, Jacqueline M Kimmey, Bree B Aldridge, Christina L Stallings
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007115 (2017)
DNA replication is fundamental for life, yet a detailed understanding of bacterial DNA replication is limited outside the organisms Escherichia coli and Bacillus subtilis. Many bacteria, including mycobacteria, encode no identified homologs of helica
Externí odkaz:
https://doaj.org/article/45b006c6d09f4d10b345839bf20fcd60
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-21 (2011)
Abstract Receptor‐mediated apoptosis proceeds via two pathways: one requiring only a cascade of initiator and effector caspases (type I behavior) and the second requiring an initiator–effector caspase cascade and mitochondrial outer membrane perm
Externí odkaz:
https://doaj.org/article/dce08ec02767452bb61c26043a4628ed
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004394 (2014)
Mycobacterium tuberculosis (Mtb) remains a major public health problem, with an effective vaccine continuing to prove elusive. Progress in vaccination strategies has been hampered by a lack of appreciation of the bacterium's response to dynamic chang
Externí odkaz:
https://doaj.org/article/9711b21be847439085cb5b8439e73408
Autor:
Michael C Chao, Karen J Kieser, Shoko Minami, Daniela Mavrici, Bree B Aldridge, Sarah M Fortune, Tom Alber, Eric J Rubin
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003197 (2013)
Peptidoglycan hydrolases are a double-edged sword. They are required for normal cell division, but when dysregulated can become autolysins lethal to bacteria. How bacteria ensure that peptidoglycan hydrolases function only in the correct spatial and
Externí odkaz:
https://doaj.org/article/30ff609cce2e49018fc57f5688d1a709
Autor:
Bree B Aldridge, Julio Saez-Rodriguez, Jeremy L Muhlich, Peter K Sorger, Douglas A Lauffenburger
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 4, p e1000340 (2009)
When modeling cell signaling networks, a balance must be struck between mechanistic detail and ease of interpretation. In this paper we apply a fuzzy logic framework to the analysis of a large, systematic dataset describing the dynamics of cell signa
Externí odkaz:
https://doaj.org/article/34f6dc7f8af2479fa4f3cfbd328bbd55
Autor:
Qingyun Liu, Junhao Zhu, Charles L. Dulberger, Sydney Stanley, Sean Wilson, Eun Seon Chung, Xin Wang, Peter Culviner, Yue J. Liu, Nathan D. Hicks, Gregory H. Babunovic, Samantha R. Giffen, Bree B. Aldridge, Ethan C. Garner, Eric J. Rubin, Michael C. Chao, Sarah M. Fortune
Publikováno v:
Science
The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis ( Mtb ) clinical isolates has identified an essential transcriptional reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d37880064609bcfc7844c5dacb52098
https://doi.org/10.1126/science.abq2787
https://doi.org/10.1126/science.abq2787
Publikováno v:
bioRxiv
The ability of bacterial pathogens to regulate growth is crucial to control homeostasis, virulence, and drug response. Yet, we do not understand the growth and cell cycle behaviors ofMycobacterium tuberculosis(Mtb), a slow-growing pathogen, at the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23204bea657c9acb1f90ae22e92a0f9a
https://europepmc.org/articles/PMC10245742/
https://europepmc.org/articles/PMC10245742/
Autor:
Talia Greenstein, Bree B. Aldridge
Publikováno v:
Frontiers in Cellular and Infection Microbiology. 12
Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed. The adaptation of Mycobacterium tuberculosis to various lesion mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4152e237938d06caf0f8fd5b1810dc4b
Publikováno v:
Curr Opin Microbiol
Interest in antibiotic combination therapy is increasing due to antimicrobial resistance and a slowing antibiotic pipeline. However, aside from specific indications, combination therapy in the clinic is often not administered systematically; instead,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712d789ffdc3ae78f700c583b3d2ea0c
https://doi.org/10.1016/j.mib.2021.09.006
https://doi.org/10.1016/j.mib.2021.09.006