Zobrazeno 1 - 10
of 3 968
pro vyhledávání: '"Breck A"'
Autor:
Nathan P. Bullen, Cydney N. Johnson, Shelby E. Andersen, Garima Arya, Sonia R. Marotta, Yan-Jiun Lee, Peter R. Weigele, John C. Whitney, Breck A. Duerkop
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The prevalence of multidrug resistant (MDR) bacterial infections continues to rise as the development of antibiotics needed to combat these infections remains stagnant. MDR enterococci are a major contributor to this crisis. A potential ther
Externí odkaz:
https://doaj.org/article/bb8b9b0015074f53b51e73e831da1801
Autor:
Jessie L Maier, Craig Gin, Benjamin Callahan, Emma K Sheriff, Breck A Duerkop, Manuel Kleiner
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012301 (2024)
Salmonella enterica Serovar Typhimurium (Salmonella) and its bacteriophage P22 are a model system for the study of horizontal gene transfer by generalized transduction. Typically, the P22 DNA packaging machinery initiates packaging when a short seque
Externí odkaz:
https://doaj.org/article/9030f2f517a648eea97367966336161b
Autor:
Madison E. Stellfox, Carolyn Fernandes, Ryan K. Shields, Ghady Haidar, Kailey Hughes Kramer, Emily Dembinski, Mihnea R. Mangalea, Garima Arya, Gregory S. Canfield, Breck A. Duerkop, Daria Van Tyne
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Enterococcus faecium is a member of the human gastrointestinal (GI) microbiota but can also cause invasive infections, especially in immunocompromised hosts. Enterococci display intrinsic resistance to many antibiotics, and most clinical E.
Externí odkaz:
https://doaj.org/article/9d1898c6b1d8494491170f7dce759c49
Autor:
James F. Colbert, Joshua M. Kirsch, Christopher L. Erzen, Christophe J. Langouët-Astrié, Grace E. Thompson, Sarah A. McMurtry, Jennifer M. Kofonow, Charles E. Robertson, Elizabeth J. Kovacs, Ryan C. Sullivan, Joseph A. Hippensteel, Namrata V. Sawant, Nicole J. De Nisco, Bruce D. McCollister, Robert S. Schwartz, Alexander R. Horswill, Daniel N. Frank, Breck A. Duerkop, Eric P. Schmidt
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host, however, has failed to identify therapies that improve sepsis outcomes in the elderly.
Externí odkaz:
https://doaj.org/article/3534f0ab7eb1418a8befb8cb4e008912
Autor:
Joshua M Kirsch, Shannon Ely, Madison E Stellfox, Karthik Hullahalli, Phat Luong, Kelli L Palmer, Daria Van Tyne, Breck A Duerkop
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011424 (2023)
Insertion sequences (IS) are simple transposons implicated in the genome evolution of diverse pathogenic bacterial species. Enterococci have emerged as important human intestinal pathogens with newly adapted virulence potential and antibiotic resista
Externí odkaz:
https://doaj.org/article/4244f4d858254be781c4732ef81c4ed2
Autor:
Javier C Urcuyo, Lee Curtin, Jazlynn M Langworthy, Gustavo De Leon, Barrett Anderies, Kyle W Singleton, Andrea Hawkins-Daarud, Pamela R Jackson, Kamila M Bond, Sara Ranjbar, Yvette Lassiter-Morris, Kamala R Clark-Swanson, Lisa E Paulson, Chris Sereduk, Maciej M Mrugala, Alyx B Porter, Leslie Baxter, Marcela Salomao, Kliment Donev, Miles Hudson, Jenna Meyer, Qazi Zeeshan, Mithun Sattur, Devi P Patra, Breck A Jones, Rudy J Rahme, Matthew T Neal, Naresh Patel, Pelagia Kouloumberis, Ali H Turkmani, Mark Lyons, Chandan Krishna, Richard S Zimmerman, Bernard R Bendok, Nhan L Tran, Leland S Hu, Kristin R Swanson
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0287767 (2023)
Brain cancers pose a novel set of difficulties due to the limited accessibility of human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet the mapping between MRI features and underlying bi
Externí odkaz:
https://doaj.org/article/9e0a2b9676eb4c9582d28ead00177ffa
LLM (large language model) practitioners commonly notice that outputs can vary for the same inputs, but we have been unable to find work that evaluates LLM stability as the main objective. In our study of 6 deterministically configured LLMs across 8
Externí odkaz:
http://arxiv.org/abs/2408.04667
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-17 (2020)
Abstract Background Horizontal gene transfer (HGT) plays a central role in microbial evolution. Our understanding of the mechanisms, frequency, and taxonomic range of HGT in polymicrobial environments is limited, as we currently rely on historical HG
Externí odkaz:
https://doaj.org/article/8923f706a0ee4526bca0bf7475779694
Autor:
Cydney N. Johnson, Dennise Palacios Araya, Viviane Schink, Moutusee Islam, Mihnea R. Mangalea, Emily K. Decurtis, Tuong‐Vi C. Ngo, Kelli L. Palmer, Breck A. Duerkop
Publikováno v:
MicrobiologyOpen, Vol 11, Iss 2, Pp n/a-n/a (2022)
Abstract The human microbiota harbors diverse bacterial and bacteriophage (phage) communities. Bacteria evolve to overcome phage infection, thereby driving phage evolution to counter bacterial resistance. Understanding how phages select for genetic a
Externí odkaz:
https://doaj.org/article/27e7a8cf413d44fabd87f4cddee9ef78
Autor:
Ashlan J. Kunz Coyne, Kyle Stamper, Razieh Kebriaei, Dana J. Holger, Amer El Ghali, Taylor Morrisette, Biswajit Biswas, Melanie Wilson, Michael V. Deschenes, Gregory S. Canfield, Breck A. Duerkop, Cesar A. Arias, Michael J. Rybak
Publikováno v:
Antibiotics, Vol 11, Iss 9, p 1175 (2022)
Multidrug-resistant (MDR) Enterococcus faecium is a challenging nosocomial pathogen known to colonize medical device surfaces and form biofilms. Bacterio (phages) may constitute an emerging anti-infective option for refractory, biofilm-mediated infec
Externí odkaz:
https://doaj.org/article/e296d9e2d0124deda1a74cc2f9037bc0