Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brecht Vanbillemont"'
Autor:
Brecht Vanbillemont, Anna-Lena Greiner, Vanessa Ehrl, Tim Menzen, Wolfgang Friess, Andrea Hawe
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100180- (2023)
Freeze-drying is a time and cost-intensive process. The primary drying phase is the main target in a process optimization exercise. Biopharmaceuticals require an amorphous matrix for stabilization, which may collapse during primary drying if the crit
Externí odkaz:
https://doaj.org/article/e764e9c5ffc64cc7acc9036b48afe182
Autor:
Brecht Vanbillemont, Thomas De Beer
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100057- (2020)
Oral lyophilizates also called orally disintegrating tablets (ODTs) are a patient friendly and convenient dosage form. They are manufactured by dosing a suspension in blister cups and subsequently freeze-drying these blisters to achieve porous tablet
Externí odkaz:
https://doaj.org/article/14ab8062f4e14c82b4b9e7ac1749e0f3
Autor:
Gust Nuytten, Susan Ríos Revatta, Pieter-Jan Van Bockstal, Ashish Kumar, Joris Lammens, Laurens Leys, Brecht Vanbillemont, Jos Corver, Chris Vervaet, Thomas De Beer
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2076 (2021)
During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis. The aqueous drug formulation subsequently spreads over the inner vial wall, while a cold gas f
Externí odkaz:
https://doaj.org/article/8426039a85ab42959ba7b16b7114420a
Autor:
Brecht Vanbillemont, Joris Lammens, Wannes Goethals, Chris Vervaet, Matthieu N. Boone, Thomas De Beer
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 430 (2020)
Maintaining chemical and physical stability of the product during freeze-drying is important but challenging. In addition, freeze-drying is typically associated with long process times. Therefore, mechanistic models have been developed to maximize dr
Externí odkaz:
https://doaj.org/article/78f58310d5594c37a141353a2d984fe6
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 181 (2020)
The standard operation of a batch freeze-dryer is protocol driven. All freeze-drying phases (i.e., freezing, primary and secondary drying) are programmed sequentially at fixed time points and within each phase critical process parameters (CPPs) are t
Externí odkaz:
https://doaj.org/article/b18345b20fdf456e8e4661b9b32b8bd9
Autor:
T. De Beer, Laurens Leys, Jos Corver, P.J. Van Bockstal, G. Nuytten, Chris Vervaet, Brecht Vanbillemont, Joris Lammens
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 157:97-107
An innovative continuous spin-freeze-drying technology for unit doses was recently developed. For this technology, a mechanistic primary drying model was developed allowing the calculation of the optimal dynamic drying trajectory for spin-frozen form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d193a89f8bff1d17e610f01acfa34e11
https://doi.org/10.1016/j.ejpb.2020.09.009
https://doi.org/10.1016/j.ejpb.2020.09.009
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3308-3318
The long-term stability of therapeutic protein products can be extended by freeze-drying. However, the freeze-drying process itself has several harmful stresses. A rationalized formulation design can significantly mitigate protein damage caused by fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed0d5bb45d11aaf768fc4e2680d4060
https://doi.org/10.1016/j.xphs.2020.07.023
https://doi.org/10.1016/j.xphs.2020.07.023
Publikováno v:
European Journal of Pharmaceutical Sciences. 132:106-117
Recently, an innovative continuous manufacturing technology for a pharmaceutical oral suspension was proposed, based on two consecutive mixing units. A limitation of this technology is the need to dissolve or disperse powder-based raw materials in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe23a5ac768c8afbe72841e4ba0ecb8
https://doi.org/10.1016/j.ejps.2019.02.036
https://doi.org/10.1016/j.ejps.2019.02.036
Autor:
Brecht Vanbillemont, Thomas De Beer
Publikováno v:
International Journal of Pharmaceutics. 624:121891
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86016df17623f4e4f18dc648579d9a7
https://doi.org/10.1016/j.ijpharm.2022.121891
https://doi.org/10.1016/j.ijpharm.2022.121891
Publikováno v:
Pharmaceutics
Volume 12
Issue 2
Pharmaceutics, Vol 12, Iss 2, p 181 (2020)
PHARMACEUTICS
Volume 12
Issue 2
Pharmaceutics, Vol 12, Iss 2, p 181 (2020)
PHARMACEUTICS
The standard operation of a batch freeze-dryer is protocol driven. All freeze-drying phases (i.e., freezing, primary and secondary drying) are programmed sequentially at fixed time points and within each phase critical process parameters (CPPs) are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b73b6096ea0d7a9400c4471d8d29b4