Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells

Autor: Sebastian Reith, Brecht A. G. Willems, Michael J. Jacobs, Elham Bidar, Barend Mees, Ehsan Natour, Nadina Stadler, Nikolaus Marx, Malgorzata Furmanik, Mathias Burgmaier, Kathrin Burgmaier, Sylvia Heeneman, Leon J. Schurgers, Ploingarm Petsophonsakul, Florian Kahles, Chris P. M. Reutelingsperger, Felix Gremse

Publikováno v: Cardiovascular research 118(9), 2196-2210 (2022). doi:10.1093/cvr/cvab244
Cardiovascular Research, 118(9), 2196-2210. Oxford University Press

Aims Smokers are at increased risk of cardiovascular events. However, the exact mechanisms through which smoking influences cardiovascular disease resulting in accelerated atherosclerosis and vascular calcification are unknown. The aim of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fe15d22a7eb27c9de2da9f49018679
https://doi.org/10.1093/cvr/cvab244

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling

Autor: Marjolein M. J. Caron, Martijn L. Chatrou, Tim J. M. Welting, Leon J. Schurgers, Michael Stock, Malgorzata Furmanik, Chris P. M. Reutelingsperger, Carla Viegas, Marta S. Rafael, Brecht A. G. Willems, Dennis H. M. Kusters, Cees Vermeer, Dina C. Simes

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports, 8:4961. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports

Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e2de2037b337aad5e2bb08a62a07e2
https://cris.maastrichtuniversity.nl/en/publications/0ee51a21-933b-4c0a-9b51-6f4ddbcd068e

The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification

Autor: Cees Vermeer, Leon J. Schurgers, Chris P. M. Reutelingsperger, Brecht A. G. Willems

Publikováno v: Molecular Nutrition & Food Research, 58(8), 1620-1635. Wiley

In the past few decades vitamin K has emerged from a single-function "haemostasis vitamin" to a "multi-function vitamin." The use of vitamin K antagonists (VKA) inevitably showed that the inhibition was not restricted to vitamin K dependent coagulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1399225c4374bcb43199adc0a4127b
https://doi.org/10.1002/mnfr.201300743

Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet

Autor: Mauro Perretti, Chris P. M. Reutelingsperger, Leon J. Schurgers, Dennis H. M. Kusters, Martijn L. Chatrou, Erik A.L. Biessen, Brecht A. G. Willems, Matthias Bauwens, Emiel P. C. van der Vorst, Marijke De Saint-Hubert, Stefania Bena

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130484 (2015)
PLoS ONE
PLOS ONE, 10(6):e0130484. Public Library of Science

OBJECTIVE: To investigate therapeutic effects of annexin A1 (anxA1) on atherogenesis in LDLR-/- mice. METHODS: Human recombinant annexin A1 (hr-anxA1) was produced by a prokaryotic expression system, purified and analysed on phosphatidylserine (PS) b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147b7d20050c32be274b6f11b2f0d508
https://cris.maastrichtuniversity.nl/en/publications/623bdd53-9848-4709-8cb5-aa92fa0bae19

Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and gamma-carboxylation status

Autor: Carla Viegas, Acácio Ramos, Dina C. Simes, Sofia Rebelo Santos, Elke Theuwissen, Marta S. Rafael, Cees Vermeer, Brecht A. G. Willems, Marjolein Herfs, Sofia Cavaco

Publikováno v: Molecular Nutrition & Food Research, 58(8), 1636-1646. Wiley

Scope Gla-rich protein (GRP) is a vitamin K dependent protein, characterized by a high density of γ-carboxylated Glu residues, shown to accumulate in mouse and sturgeon cartilage and at sites of skin and vascular calcification in humans. Therefore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcca1e54974a0ce4a59b443c8c604dac
https://cris.maastrichtuniversity.nl/en/publications/9a6e2d34-694e-4fb6-9c77-8aec9dc4ac27