Výsledky vyhledávání - "Breast cancer vaccine"

Akademický článek

Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines

Autor: Sruthi Ravindranathan, Khue G. Nguyen, Samantha L. Kurtz, Haven N. Frazier, Sean G. Smith, Bhanu prasanth Koppolu, Narasimhan Rajaram, David A. Zaharoff

Publikováno v: Breast Cancer Research, Vol 20, Iss 1, Pp 1-17 (2018)

Abstract Background Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current adjuvant therapies a

Externí odkaz: https://doaj.org/article/3c4716e6a28d4df888466a1360de98b4

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Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines

Autor: Samantha L. Kurtz, Sruthi Ravindranathan, Bhanu prasanth Koppolu, Haven N. Frazier, Khue G. Nguyen, Sean G. Smith, Narasimhan Rajaram, David A. Zaharoff

Publikováno v: Breast Cancer Research : BCR
Breast Cancer Research, Vol 20, Iss 1, Pp 1-17 (2018)

Background Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current adjuvant therapies are unable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f4e899f07ff0b96d9d9f9ad312820c
https://doi.org/10.1186/s13058-018-1054-3

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Autor: Manuela Milani, Francesco Lanza, Daniele Spada, Daniele Generali, Angela Gobbi, Paolo Pedrazzoli, Massimo Martino, Laura Zanotti, Alberto Bottini, Andrea Ravelli, Simone Anfossi, Maria Rosa Cappelletti, James M. Reuben

Publikováno v: Expert review of anticancer therapy. 15(6)

Because its original use as a treatment for hematologic disease, more recently immunotherapy has emerged as a novel effective therapeutic strategy for solid malignancies, such as melanoma and prostate carcinoma. For breast carcinoma, an immunologic t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8342b39cb022f3e60fa3e5f3a5bb51d2
https://pubmed.ncbi.nlm.nih.gov/25927868

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A Phase I Vaccine Safety and Chemotherapy Dose-Finding Trial of an Allogeneic GM-CSF–Secreting Breast Cancer Vaccine Given in a Specifically Timed Sequence with Immunomodulatory Doses of Cyclophosphamide and Doxorubicin. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland

Autor: Steven Piantadosi, Janice M. Davis-Sproul, Barbara A. Biedrzycki, John H. Fetting, Reilly Rt, Irena Tartakovsky, Antonio C. Wolff, K Visvanathan, Nancy E. Davidson, Stearns, Elizabeth M. Jaffee, Leisha A. Emens, Deborah K. Armstrong, Beth Onners

Publikováno v: Human Gene Therapy. 15:313-337

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41c17ad2c43e5bc085c85aac5c838bb0
https://doi.org/10.1089/104303404322886165

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Enhancement of an Allogeneic GM-CSF-Secreting Breast Cancer Vaccine by Immunomodulatory Doses of Cyclophosphamide and Doxorubicin

Autor: Elizabeth M. Jaffee, Leisha A. Emens

Advanced breast cancer is managed with hormonal agents or conventional cytotoxic drugs, but intrinsic drug resistance ultimately causes treatment failure. We have applied the use of tumor cells genetically modified to secrete GM-CSF to the preclinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c49a413d165e0ee2bd27cfb5468c2e2b
https://doi.org/10.21236/ada417167

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A phase I study of an autologous GM-CSF-secreting breast cancer vaccine

Autor: Julie Najita, Erica L. Mayer, Karen S. Anderson, M Hassett, B Shoji, Sahar Sibani, EP Winer, Joshua LaBaer, Jessica Wong, K Hannagan, Glenn Dranoff, Y Colson, FS Hodi, Christine Canning, Tetsuro Sasada

Publikováno v: Cancer Research. 69:4124

Abstract #4124 Background: Vaccination with tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GM-CSF) generates potent, specific, and long-lasting anti-tumor immunity in multiple tumor models. At DF/HCC, over 100 pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4f3355fd71e8573de2469e0ba6f8ee3
https://doi.org/10.1158/0008-5472.sabcs-4124

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