Zobrazeno 1 - 10
of 1 625
pro vyhledávání: '"Breast cancer resistance protein"'
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 57 (2024)
Rivaroxaban is a direct factor Xa inhibitor. Its interindividual variability is large and may be connected to the occurrence of adverse drug reactions or drug inefficacy. Pharmacogenetics studies concentrating on the reasons underlying rivaroxaban's
Externí odkaz:
https://doaj.org/article/db6507ca7e5242c3a602cea4dd53b3b9
Autor:
Lydia Kuhnert, Robert Kuhnert, Menyhárt B. Sárosi, Cathleen Lakoma, Birte K. Scholz, Peter Lönnecke, Evamarie Hey‐Hawkins, Walther Honscha
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 280-290 (2024)
Success of chemotherapy is often hampered by multidrug resistance. One mechanism for drug resistance is the elimination of anticancer drugs through drug transporters, such as breast cancer resistance protein (BCRP; also known as ABCG2), and causes a
Externí odkaz:
https://doaj.org/article/e96a44f6f69c429da99bfd278b0a0705
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30207- (2024)
P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) multidrug resistance (MDR) transporters are localized at the luminal surface of the blood-brain barrier (BBB). They confer fetal brain protection against harmful compounds that may be
Externí odkaz:
https://doaj.org/article/688ecff3f64448daa6516d6e1fe942b5
Autor:
Odelia Tepper-Shimshon, Nino Tetro, Roa’a Hamed, Natalia Erenburg, Emmanuelle Merquiol, Gourab Dey, Agam Haim, Tali Dee, Noa Duvdevani, Talin Kevorkian, Galia Blum, Eylon Yavin, Sara Eyal
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1211 (2024)
The space environment can affect the function of all physiological systems, including the properties of cell membranes. Our goal in this study was to explore the effect of simulated microgravity (SMG) on the cellular uptake of small molecules based o
Externí odkaz:
https://doaj.org/article/a437c92619c2452886187536e3081d90
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 992 (2024)
Of the 450 cell membrane transporters responsible for shuttling substrates, nutrients, hormones, neurotransmitters, antioxidants, and signaling molecules, approximately nine are associated with clinically relevant drug–drug interactions (DDIs) due
Externí odkaz:
https://doaj.org/article/e673aa70b048492ea899e5b6e6643a58
Altered Expression of BCRP Impacts Fetal Accumulation of Rosuvastatin in a Rat Model of Preeclampsia
Autor:
Wanying Dai, Micheline Piquette-Miller
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 884 (2024)
Expression of the breast cancer resistance protein (BCRP/ABCG2) transporter is downregulated in placentas from women with preeclampsia (PE) and in an immunological rat model of PE. While many drugs are substrates of this important efflux transporter,
Externí odkaz:
https://doaj.org/article/1a8e69d2455d4e28b1f842cf50cc7c03
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Autor:
Isaac Tuffour, Setor Amuzu, Hala Bayoumi, Iram Surtaj, Colin Parrish, Rachel Willand-Charnley
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Cancers utilize sugar residues to engage in multidrug resistance. The underlying mechanism of action involving glycans, specifically the glycan sialic acid (Sia) and its various functional group alterations, has not been explored. ATP-binding cassett
Externí odkaz:
https://doaj.org/article/eb84a0775c4346ecbc9bd124f74f1130