Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis.

Autor: Brea K Hampton, Kenneth S Plante, Alan C Whitmore, Colton L Linnertz, Emily A Madden, Kelsey E Noll, Samuel P Boyson, Breantie Parotti, James G Xenakis, Timothy A Bell, Pablo Hock, Ginger D Shaw, Fernando Pardo-Manuel de Villena, Martin T Ferris, Mark T Heise

Publikováno v: PLoS Genetics, Vol 18, Iss 12, p e1010548 (2022)

Variation in immune homeostasis, the state in which the immune system is maintained in the absence of stimulation, is highly variable across populations. This variation is attributed to both genetic and environmental factors. However, the identity an

Externí odkaz: https://doaj.org/article/15976cb8c23a4cb6bff3f652de673521

Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis.

Autor: Hampton, Brea K.^1,2 (AUTHOR), Plante, Kenneth S.² (AUTHOR), Whitmore, Alan C.² (AUTHOR), Linnertz, Colton L.² (AUTHOR), Madden, Emily A.³ (AUTHOR), Noll, Kelsey E.³ (AUTHOR), Boyson, Samuel P.^1,2 (AUTHOR), Parotti, Breantie² (AUTHOR), Xenakis, James G.² (AUTHOR), Bell, Timothy A.² (AUTHOR), Hock, Pablo² (AUTHOR), Shaw, Ginger D.² (AUTHOR), de Villena, Fernando Pardo-Manuel^2,4 (AUTHOR), Ferris, Martin T.² (AUTHOR) mtferris@email.unc.edu, Heise, Mark T.^2,3,4 (AUTHOR) mtferris@email.unc.edu

Publikováno v: PLoS Genetics. 12/27/2022, Vol. 18 Issue 12, p1-20. 20p.