Výsledky vyhledávání - "Breanna Wallace"

Supplementary Tables 1-5, Supplementary Methods and Materials from Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

Autor: Timothy Hoey, Austin Gurney, John Lewicki, Ann M. Kapoun, Chun Zhang, Min Wang, Breanna Wallace, Tracy Tang, Jalpa Shah, Aaron Sato, Rene Meisner, William R. Henner, Belinda Cancilla, Jennifer Cain, Christopher Bond, Fumiko Axelrod, Marcus M. Fischer, Wan-Ching Yen

Table S1: OMP-59R5 binding data as assessed by surface plasmon resonance (Biacore); Table S2. Histopathology of human pancreatic tumors; Table S3. Effect of anti-Notch2/3 antibody OMP-59R5 in combination with gemcitabine on growth of pancreatic xenog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf498724cd8f0c5646ff30984a2c9c4
https://doi.org/10.1158/1078-0432.22458093

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Data from Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

Purpose: The Notch pathway plays an important role in both stem cell biology and cancer. Dysregulation of Notch signaling has been reported in several human tumor types. In this report, we describe the development of an antibody, OMP-59R5 (tarextumab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f473b99c67334f0815470d792e6624
https://doi.org/10.1158/1078-0432.c.6523824.v1

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Supplementary Figures 1-8 from Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

Figure S1A. Binding affinities of OMP-59R5 to human (h) Notch1-4 receptors; Figure S1B. Alignment of the EGF repeats 10-15 of Notch2 and 9-14 of Notch3 from human (h), cynomolgus monkey (cyno), and mouse (m); Figure S2. Human NOTCH1, NOTCH2 and NOTCH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f59c2b422fb81b4b510586fa10a689b
https://doi.org/10.1158/1078-0432.22458096.v1

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Dual inhibition of VEGF and DLL4 ameliorates anti-DLL4 cardiac endothelial hypertrophy in cynomolgus monkeys

Autor: Gretchen Argast, Rene Meisner, Yu-Wang Liu, Tim Hoey, Breanna Wallace, Min Wang, Ann M. Kapoun

Publikováno v: Journal of Pharmacological and Toxicological Methods. 81:358

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ac5940b29091f1df54c5a4d6b13ea7d
https://doi.org/10.1016/j.vascn.2016.02.076

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Abstract A41: Use of patient-derived tumor xenografts (PDX) for discovery and development of an anti-Notch2/3 monoclonal antibody targeting cancer stem cells

Publikováno v: Clinical Cancer Research. 22:A41-A41

Accumulating evidence has suggested that tumors may arise and grow as a result of the formation of a subset cell population termed cancer stem cells (CSC) or tumor initiating cells. Several research reports have indicated that CSCs are relatively res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a27437dbb392d89d6e80e0d7b837b7a
https://doi.org/10.1158/1557-3265.pdx16-a41

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Abstract A33: Combined therapy of a novel anti-NOTCH2/3 antibody with paclitaxel inhibits tumor growth in a patient-derived breast tumor xenograft

Autor: Christopher Murriel, Austin L. Gurney, Breanna Wallace, John Lewicki, Jalpa Shah, Jennifer Cain, Tim Hoey, Aaron K. Sato, Jie Wei, Ann M. Kapoun, Tracy Tang, Cancilla Belinda, Min Wang

Publikováno v: Clinical Cancer Research. 21:A33-A33

Cancer stem cells (CSCs) have been identified as the small subpopulation of cells in many cancers and are thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug resistance. The NOTCH pathway, comprised of ligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a14cef99e05fc9dacd5e72eef2357f2
https://doi.org/10.1158/1557-3265.pms14-a33

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Abstract 213: Novel NOTCH3 activating mutations identified in tumors sensitive to OMP-59R5, a monoclonal antibody targeting the Notch2 and Notch3 receptors

Autor: Tracy Tang, Jalpa Shah, Jennifer Cain, Aaron K. Sato, Ann M. Kapoun, Belinda Cancilla, Breanna Wallace, Min Wang, Tim Hoey, Jie Wei, Austin L. Gurney, John Lewicki, Chris Muriel

Publikováno v: Cancer Research. 73:213-213

The Notch signaling pathway, driven by four Notch family receptors (NOTCH1-4) and five canonical Notch ligands (DLL1, DLL3, DLL4, JAG1, and JAG2) in humans, critically regulates key functions during embryonic development as well as stem cell maintena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::610c0f674d591ce6b7ca8a5859d3680d
https://doi.org/10.1158/1538-7445.am2013-213

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