Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Breanna S, Vollmar"'
Autor:
Thomas H. Pillow, Andrew G. Polson, Peter S. Dragovich, Hans K. Erickson, Pragya Adhikari, John Wai, Zijin Xu, Jinhua Chen, Katherine R. Kozak, Josefa dela Cruz-Chuh, Keyang Xu, Carl Ng, Amrita V. Kamath, Douglas D. Leipold, Shang-Fan Yu, Mary Ann T. Go, Geoffrey del Rosario, Fiona Zhong, Melissa M. Schutten, Chris Frantz, Breanna S. Vollmar
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5429ac6c382f94a2b29d630d8d1ebd26
https://doi.org/10.1158/1535-7163.22522233
https://doi.org/10.1158/1535-7163.22522233
Autor:
Thomas H. Pillow, Andrew G. Polson, Peter S. Dragovich, Hans K. Erickson, Pragya Adhikari, John Wai, Zijin Xu, Jinhua Chen, Katherine R. Kozak, Josefa dela Cruz-Chuh, Keyang Xu, Carl Ng, Amrita V. Kamath, Douglas D. Leipold, Shang-Fan Yu, Mary Ann T. Go, Geoffrey del Rosario, Fiona Zhong, Melissa M. Schutten, Chris Frantz, Breanna S. Vollmar
Calicheamicin antibody–drug conjugates (ADCs) are effective therapeutics for leukemias with two recently approved in the United States: Mylotarg (gemtuzumab ozogamicin) targeting CD33 for acute myeloid leukemia and Besponsa (inotuzumab ozogamicin)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953a865f6922c43da57998015e9032ac
https://doi.org/10.1158/1535-7163.c.6543312.v1
https://doi.org/10.1158/1535-7163.c.6543312.v1
Autor:
Breanna S. Vollmar, Mingjian Fei, Wei-Ching Liang, Daniel D. Bravo, Joy Wang, Lanlan Yu, Nick Corr, Gu Zhang, Erin McNamara, Shabkhaiz Masih, Elin Chee, Gawon Shin, Rachana Ohri, Douglas D. Leipold, Cong Wu, Edward Dere, Jianyong Wang, Haochu Huang, Yan Wu, Minhong Yan
Publikováno v:
Bioconjugate chemistry. 33(10)
Here, we explore whether PEGylation of antibodies can modulate their biodistribution to the eye, an organ once thought to be immune privileged but has recently been shown to be accessible to IV-administered large molecules, such as antibodies. We cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa651a8d252b4195b5e0c6a4232b6c8
https://pubmed.ncbi.nlm.nih.gov/36153839
https://pubmed.ncbi.nlm.nih.gov/36153839
Autor:
Jérémie Decalf, Jeffrey Tom, Elaine Mai, Hilda Hernandez-Barry, Cameron L. Noland, Breanna S. Vollmar, Alice Li, Hong Li, Daniel Xie, Lunchao Zhu, Jian Payandeh, Kelly M. Loyet, Cong Wu, Laetitia Comps-Agrar, Christine Moussion, Matthew L. Albert, Aimin Song
Publikováno v:
Bioorganic Chemistry. 120:105655
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325b6009dadec4cd5f94c52b2d5e05ea
https://doi.org/10.1016/j.bioorg.2022.105655
https://doi.org/10.1016/j.bioorg.2022.105655
Autor:
Chris Frantz, Keyang Xu, Katherine R. Kozak, Thomas H. Pillow, Zijin Xu, Geoffrey Del Rosario, Pragya Adhikari, Douglas D. Leipold, Andrew Polson, Jinhua Chen, Shang-Fan Yu, Mary Ann T. Go, Breanna S. Vollmar, Josefa dela Cruz-Chuh, Peter S. Dragovich, Amrita V. Kamath, Hans Erickson, Fiona Zhong, John S. Wai, Carl Ng, Melissa Schutten
Publikováno v:
Molecular cancer therapeutics. 20(6)
Calicheamicin antibody–drug conjugates (ADCs) are effective therapeutics for leukemias with two recently approved in the United States: Mylotarg (gemtuzumab ozogamicin) targeting CD33 for acute myeloid leukemia and Besponsa (inotuzumab ozogamicin)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ea774d110d9f3fb9ee986f88f4881a
https://pubmed.ncbi.nlm.nih.gov/33722856
https://pubmed.ncbi.nlm.nih.gov/33722856
Autor:
Leanna Staben, Josefa dela Cruz-Chuh, Hoa Le, Thomas H. Pillow, Binqing Wei, Dian Su, Peter S. Dragovich, Breanna S. Vollmar, Peter W. Fan, S. Cyrus Khojasteh, Gail Lewis Phillips, Yong Ma, Richard Vandlen, Cornelis E. C. A. Hop, Sudheer Bobba, Chenghong Zhang, Jun Guo, Donglu Zhang, Jack Sadowsky, Katherine R. Kozak
Publikováno v:
Bioconjugate Chemistry. 29:267-274
The valine-citrulline (Val-Cit) dipeptide and p-aminobenzyl (PAB) spacer have been commonly used as a cleavable self-immolating linker in ADC design including in the clinically approved ADC, brentuximab vedotin (Adcetris). When the same linker was us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa602fd575a49e02dae4f0df0c8480b
https://doi.org/10.1021/acs.bioconjchem.7b00576
https://doi.org/10.1021/acs.bioconjchem.7b00576
Autor:
Hilda Hernandez-Barry, Jérémie Decalf, Hong Li, Cameron L. Noland, Alice Li, Elaine Mai, Jian Payandeh, Daniel Xie, Laetitia Comps-Agrar, Lunchao Zhu, Aimin Song, Cong Wu, Matthew L. Albert, Jeffrey Tom, Breanna S. Vollmar, Christine Moussion
Publikováno v:
Bioorganic Chemistry. 116:105376
Antitumor immune responses depend on the infiltration of solid tumors by effector T cells, a process guided by chemokines. In particular, the chemokine CXCL10 has been shown to play a critical role in mediating recruitment of CXCR3 + cytolytic T and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1496c45fbc1fcf15dcda7afeb16abb
https://doi.org/10.1016/j.bioorg.2021.105376
https://doi.org/10.1016/j.bioorg.2021.105376
Autor:
Jianhui Zhou, Jintang He, Breanna S. Vollmar, Shang-Fan Yu, Hans Erickson, Sharon Yee, Greg A. Lazar, Binqing Wei, Aimee Fourie-O'Donohue, Genee Lee, Amrita V. Kamath, Douglas D. Leipold, Rachana Ohri, Guangmin Li, Gail Lewis Phillips, Ely Cosino, Keyang Xu, Katherine R. Kozak
Publikováno v:
Bioconjugate Chemistry. 28:2538-2548
The incorporation of cysteines into antibodies by mutagenesis allows for the direct conjugation of small molecules to specific sites on the antibody via disulfide bonds. The stability of the disulfide bond linkage between the small molecule and the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2136e028db58ed736a2814624d0b95
https://doi.org/10.1021/acs.bioconjchem.7b00365
https://doi.org/10.1021/acs.bioconjchem.7b00365
Autor:
Peter S. Dragovich, Keyang Xu, John S. Wai, Jason Oeh, Willem den Besten, Yong Ma, Richard Vandlen, Ellen Ingalla, Fang Fan, Ingrid E. Wertz, Chunjiao Chen, Steven R. Leong, Deepak Sampath, Jiawei Lu, Donglu Zhang, Katherine R. Kozak, Thomas H. Pillow, Steven J. Hartman, Breanna S. Vollmar, Changrong He, Zijin Xu, Robert A. Blake, Gail Lewis Phillips, Josefa Chuh, Rebecca K. Rowntree, Jinhua Chen, Michelle Nannini, Rachana Ohri, Jintang He, Aimee Fourie, Lingyao Meng
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(19)
A novel strategy to attach indole-containing payloads to antibodies through a carbamate moiety and a self-immolating, disulfide-based linker is described. This new strategy was employed to connect a selective estrogen receptor down-regulator (SERD) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017ee13e19eaac5efc51623fb581c8c3
https://pubmed.ncbi.nlm.nih.gov/29493023
https://pubmed.ncbi.nlm.nih.gov/29493023
Autor:
Breanna S, Vollmar, Binqing, Wei, Rachana, Ohri, Jianhui, Zhou, Jintang, He, Shang-Fan, Yu, Douglas, Leipold, Ely, Cosino, Sharon, Yee, Aimee, Fourie-O'Donohue, Guangmin, Li, Gail L, Phillips, Katherine R, Kozak, Amrita, Kamath, Keyang, Xu, Genee, Lee, Greg A, Lazar, Hans K, Erickson
Publikováno v:
Bioconjugate chemistry. 28(10)
The incorporation of cysteines into antibodies by mutagenesis allows for the direct conjugation of small molecules to specific sites on the antibody via disulfide bonds. The stability of the disulfide bond linkage between the small molecule and the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b791b92ea51141831a4202ffa7833e4
https://pubmed.ncbi.nlm.nih.gov/28885827
https://pubmed.ncbi.nlm.nih.gov/28885827