A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02).

Autor: Hiruy H; 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland., Fuchs EJ; 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland., Marzinke MA; 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland., Bakshi RP; 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland., Breakey JC; 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland., Aung WS; 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland., Manohar M; 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland., Yue C; 2 Department of Biostatistics, Johns Hopkins School of Public Health , Baltimore, Maryland., Caffo BS; 2 Department of Biostatistics, Johns Hopkins School of Public Health , Baltimore, Maryland., Du Y; 3 Department of Radiology, Johns Hopkins School of Medicine , Baltimore, Maryland., Abebe KZ; 4 Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania., Spiegel HM; 5 HJF-DAIDS, a Division of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health , Department of Health and Human Services, Bethesda, Maryland., Rohan LC; 4 Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.; 6 Magee-Womens Research Institute , Pittsburgh, Pennsylvania., McGowan I; 4 Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.; 6 Magee-Womens Research Institute , Pittsburgh, Pennsylvania., Hendrix CW; 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland.

Publikováno v: AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2015 Nov; Vol. 31 (11), pp. 1098-108. Date of Electronic Publication: 2015 Aug 24.