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Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1′-homo-3′-isoazanucleosides and evaluation of their anticancer activity

Autor: Ferreira da Costa, Joana, García-Mera, Xerardo, Caamaño, Olga, Brea, José Manuel, Loza, María Isabel

Publikováno v: In European Journal of Medicinal Chemistry 15 June 2015 98:212-220

1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A 2B adenosine receptor antagonists: Design, synthesis, structure–affinity and structure–selectivity relationships

Autor: Stefanachi, Angela, Nicolotti, Orazio, Leonetti, Francesco, Cellamare, Saverio, Campagna, Francesco, Loza, Maria Isabel, Brea, Jose Manuel, Mazza, Fernando, Gavuzzo, Enrico, Carotti, Angelo

Publikováno v: In Bioorganic & Medicinal Chemistry 2008 16(22):9780-9789

1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: Design, synthesis, structure–affinity and structure–selectivity relationships

Autor: Stefanachi Angela, Nicolotti Orazio, Leonetti Francesco, Cellamare Saverio, Campagna Francesco, Loza Maria Isabel, Brea Jose Manuel, Mazza Fernando, Gavuzzo Enrico, Carotti Angelo

Publikováno v: Bioorganic & medicinal chemistry
16 (2008): 9780–9789.
info:cnr-pdr/source/autori:Stefanachi Angela, Nicolotti Orazio, Leonetti Francesco, Cellamare Saverio, Campagna Francesco, Loza Maria Isabel, Brea Jose Manuel, Mazza Fernando, Gavuzzo Enrico, Carotti Angelo/titolo:1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: Design, synthesis, structure–affinity and structure–selectivity relationships/doi:/rivista:Bioorganic & medicinal chemistry (Print)/anno:2008/pagina_da:9780/pagina_a:9789/intervallo_pagine:9780–9789/volume:16

A number of 1,3-dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines were prepared and evaluated as ligands of recombinant human adenosine receptors (hARs). Several 1,3-dipropyl derivatives endowed with nanomolar binding affinity at hA2B receptors, but poor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::c5e9e7149c7844f2454575b8766f72c9
http://www.cnr.it/prodotto/i/19790

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