Zobrazeno 1 - 10
of 5 067
pro vyhledávání: '"Brd4"'
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Here, we investigated the potential interaction between bromodomain-containing protein 4 (BRD4), an established epigenetic modulator and transcriptional coactivator, and p63, a member of the p53 transcription factor family, essential for epi
Externí odkaz:
https://doaj.org/article/c4e86cabbd754ae682fe120ec093756c
Autor:
Songnan Sui, Mengjun Zhong, Shuxin Zhong, Xueting Peng, Lipeng Mao, Cunte Chen, Chengwu Zeng, Oscar Junhong Luo, Yangqiu Li
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Background Exhaustion is a key factor that influences the efficacy of chimeric antigen receptor T (CAR-T) cells. Our previous study demonstrated that a bromodomain protein 4 (BRD4) inhibitor can revise the phenotype and function of exhausted
Externí odkaz:
https://doaj.org/article/4ffb6b26b2d74680b653b6d87757a4c9
Autor:
Qun Wei, Cailing Gan, Meng Sun, Yuting Xie, Hongyao Liu, Taixiong Xue, Conghui Deng, Chunheng Mo, Tinghong Ye
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-30 (2024)
Abstract Fibrosis is an excessive wound-healing response induced by repeated or chronic external stimuli to tissues, significantly impacting quality of life and primarily contributing to organ failure. Organ fibrosis is reported to cause 45% of all-c
Externí odkaz:
https://doaj.org/article/3b69c5d2e6cb4cce925f11611ff9ec65
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background iPSC reprogramming technology exhibits significant promise in the realms of clinical therapeutics, disease modeling, pharmaceutical drug discovery, and various other applications. However, the extensive utilization of this technol
Externí odkaz:
https://doaj.org/article/741d377c95c5444086207e38024cbde8
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 207-218 (2024)
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases. Emerging investigations have unveiled the function of
Externí odkaz:
https://doaj.org/article/036944c09f8e4695852137b8a918b19d
Autor:
Mahya Ahmadpour Youshanlui, Amirhossein Yari, Seyedeh Zahra Bahojb Mahdavi, Mohammad Amini, Behzad Baradaran, Ramin Ahangar, Omid Pourbagherian, Amir Ali Mokhtarzadeh
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Gastric cancer remains a significant health challenge despite advancements in diagnosis and treatment. Early detection is critical to reducing mortality, necessitating the investigation of molecular mechanisms underlying gastric cancer progr
Externí odkaz:
https://doaj.org/article/d87ffa16cfad485ab4626b16ec140e67
Autor:
Di Wu, Hongli Yin, Chun Yang, Zimu Zhang, Fang Fang, Jianwei Wang, Xiaolu Li, Yi Xie, Xiaohan Hu, Ran Zhuo, Yanling Chen, Juanjuan Yu, Tiandan Li, Gen Li, Jian Pan
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhancers(SEs)have been repo
Externí odkaz:
https://doaj.org/article/062afa89ce6c401580b5461a311d4c4c
Autor:
Jiaxin DU, Xinwei ZHANG
Publikováno v:
Chinese Journal of Lung Cancer, Vol 27, Iss 6, Pp 466-470 (2024)
NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma famil
Externí odkaz:
https://doaj.org/article/a0cfa275526a4d7196116017481925bd
Autor:
Xiaoxia Xu, Hongbin Qiu
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Gouty arthritis (GA) is characterized by monosodium urate (MSU) crystal accumulation that instigates NLRP3-mediated pyroptosis; however, the underlying regulatory mechanisms have yet to be fully elucidated. The present research en
Externí odkaz:
https://doaj.org/article/57da4f78c4c24d2da0386df79be489fd
Autor:
Chenyang Fan, Xiaohong Guo, Jie Zhang, Wen Zheng, Chonglin Shi, Yongwei Qin, Haoliang Shen, Yang Lu, Yihui Fan, Yanli Li, Liuting Chen, Renfang Mao
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Ferroptosis, an iron-dependent form of programmed cell death, is a promising strategy for cancer treatment. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and a promising target for cancer therapeutics. However, the role of
Externí odkaz:
https://doaj.org/article/5372388f4d7543909a3004da3d6d5839