Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bray Denard"'
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018)
Abstract Background Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification of responsive patien
Externí odkaz:
https://doaj.org/article/0eece74a21bb4077974b77bdc708ef08
Publikováno v:
eLife, Vol 8 (2019)
G protein-coupled receptors (GPCRs) are a family of proteins containing seven transmembrane helices, with the N- and C-terminus of the protein located at the extracellular space and cytosol, respectively. Here, we report that ceramide or related sphi
Externí odkaz:
https://doaj.org/article/0138de10dfe7410e81b26ec53b94b75c
Autor:
Bray Denard, Andrea Pavia-Jimenez, Weina Chen, Noelle S Williams, Harris Naina, Robert Collins, James Brugarolas, Jin Ye
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129233 (2015)
Doxorubicin has been shown to inhibit proliferation of cancer cells through proteolytic activation of CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor synthesized as a membrane-bound precursor. Upon doxorubicin treatme
Externí odkaz:
https://doaj.org/article/13d1229d141540a5b643ffc9d0a2992d
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108528 (2014)
CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor synthesized as a membrane-bound precursor and activated through Regulated Intramembrane Proteolysis (RIP), is essential for collagen production by osteoblasts during bon
Externí odkaz:
https://doaj.org/article/8adbf80cb35a400ebdc815c92ce9351f
Publikováno v:
eLife, Vol 1 (2012)
Doxorubicin is used extensively for chemotherapy of diverse types of cancer, yet the mechanism through which it inhibits proliferation of cancer cells remains unclear. Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in
Externí odkaz:
https://doaj.org/article/d04bf0effca94a51bc8516bc76713f91
Autor:
Lisa N. Kinch, Nick V. Grishin, Ching En Lee, Jingcheng Wang, Bray Denard, Jin Ye, Elina Esmaeilzadeh Gharehdaghi
Publikováno v:
Journal of Biological Chemistry. 294:6054-6061
Adopting a proper topology is crucial for transmembrane proteins to perform their functions. We previously reported that ceramide regulates a transmembrane protein called TM4SF20 (transmembrane 4 L six family member 20) through topological inversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6306f1b2d61c0583b26087824bd63a
https://doi.org/10.1074/jbc.ra119.007681
https://doi.org/10.1074/jbc.ra119.007681
Publikováno v:
Molecular Cell. 63:567-578
Summary TM4SF20 (transmembrane 4 L6 family 20) is a polytopic membrane protein that inhibits proteolytic processing of CREB3L1 (cAMP response element-binding protein 3-like 1), a membrane-bound transcription factor that blocks cell division and activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530682d12e3eef262b8077b4e49a0daf
https://doi.org/10.1016/j.molcel.2016.06.032
https://doi.org/10.1016/j.molcel.2016.06.032
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
G protein-coupled receptors (GPCRs) are a family of proteins containing seven transmembrane helices, with the N- and C-terminus of the protein located at the extracellular space and cytosol, respectively. Here, we report that ceramide or related sphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1fd8c3d61a7748a003174c393f141d
https://pubmed.ncbi.nlm.nih.gov/30835201
https://pubmed.ncbi.nlm.nih.gov/30835201
Autor:
Bray Denard
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::095b63274d18de119f2faa1d1842ba6a
https://doi.org/10.1096/fasebj.2018.32.1_supplement.815.3
https://doi.org/10.1096/fasebj.2018.32.1_supplement.815.3