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Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states.

Autor: Wang H; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Flores RJ; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Yarur HE; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Limoges A; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.; Columbia University - NIH Graduate Partnership Program, National Institutes of Health, Bethesda, MD, USA., Bravo-Rivera H; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Casello SM; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Loomba N; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Enriquez-Traba J; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Arenivar M; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.; Brown University - NIH Graduate Partnership Program, National Institutes of Health, Bethesda, MD, USA., Wang Q; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., Ganley R; Molecular Genetics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA., Ramakrishnan C; Departments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Fenno LE; Departments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.; Current affiliation: Departments of Psychiatry and Neuroscience, University of Texas, Austin, Dell Medical School, Austin, TX, USA., Kim Y; Departments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Deisseroth K; Departments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Or G; Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA., Dong C; Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA., Hoon MA; Molecular Genetics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA., Tian L; Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.; Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA., Tejeda HA; Neuromodulation and Synaptic Integration Unit, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 09. Date of Electronic Publication: 2024 Jan 09.