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Factor analysis is among the most-widely used methods for dimensionality reduction in genome biology, with applications from personalized health to single-cell studies. Existing implementations of factor analysis assume independence of the observed s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::139b0b54eb2468252585c8434f9ee26f
https://doi.org/10.1101/2020.11.03.366674
https://doi.org/10.1101/2020.11.03.366674
Autor:
Braunger JM; Centre for Organismal Studies, Heidelberg University, Heidelberg, 69120, Germany., Velten B; Centre for Organismal Studies, Heidelberg University, Heidelberg, 69120, Germany.; Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, 69120, Germany.
Publikováno v:
Bioinformatics (Oxford, England) [Bioinformatics] 2024 Sep 02; Vol. 40 (9).
Autor:
Braunger JM; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Cammarata LV; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Statistics, Harvard University, Cambridge, Massachusetts, USA., Sornapudi TR; Division of Biology and Chemistry, Paul Scherrer Institute, Villigen, Switzerland., Uhler C; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Shivashankar GV; Division of Biology and Chemistry, Paul Scherrer Institute, Villigen, Switzerland.; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Publikováno v:
Aging cell [Aging Cell] 2024 Mar; Vol. 23 (3), pp. e14056. Date of Electronic Publication: 2023 Dec 07.
Autor:
Buergel T; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Steinfeldt J; Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Berlin, Germany., Ruyoga G; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Pietzner M; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Bizzarri D; Molecular Epidemiology, LUMC, Leiden, the Netherlands.; Leiden Computational Biology Center, LUMC, Leiden, The Netherlands., Vojinovic D; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Upmeier Zu Belzen J; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Loock L; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Kittner P; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Christmann L; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Hollmann N; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Strangalies H; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Braunger JM; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Wild B; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Chiesa ST; Institute of Cardiovascular Sciences, University College London, London, UK., Spranger J; Department of Endocrinology & Metabolism, Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Berlin, Germany.; Center for Cardiovascular Research, Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Berlin, Germany., Klostermann F; Department of Neurology, Humboldt-Universität zu Berlin and Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.; School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany., van den Akker EB; Molecular Epidemiology, LUMC, Leiden, the Netherlands.; Leiden Computational Biology Center, LUMC, Leiden, The Netherlands.; Delft Bioinformatics Lab, TU Delft, Delft, the Netherlands., Trompet S; Department of Internal Medicine, Division of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Mooijaart SP; Department of Internal Medicine, Division of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Lavrijssen B; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Slagboom E; Molecular Epidemiology, LUMC, Leiden, the Netherlands.; Max Planck Institute for the Biology of Ageing, Cologne, Germany., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK.; Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Langenberg C; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Deanfield J; Institute of Cardiovascular Sciences, University College London, London, UK., Eils R; Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. roland.eils@bih-charite.de.; Health Data Science Unit, Heidelberg University Hospital and BioQuant, Heidelberg, Germany. roland.eils@bih-charite.de., Landmesser U; Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Berlin, Germany.
Publikováno v:
Nature medicine [Nat Med] 2022 Nov; Vol. 28 (11), pp. 2309-2320. Date of Electronic Publication: 2022 Sep 22.
Autor:
Velten B; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. b.velten@dkfz.de.; Cellular Genetics Programme, Wellcome Sanger Institute, Cambridge, UK. b.velten@dkfz.de., Braunger JM; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Argelaguet R; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.; Epigenetics Programme, Babraham Institute, Cambridge, UK., Arnol D; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Wirbel J; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany., Bredikhin D; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.; Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Zeller G; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany., Stegle O; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. o.stegle@dkfz.de.; Cellular Genetics Programme, Wellcome Sanger Institute, Cambridge, UK. o.stegle@dkfz.de.; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany. o.stegle@dkfz.de.
Publikováno v:
Nature methods [Nat Methods] 2022 Feb; Vol. 19 (2), pp. 179-186. Date of Electronic Publication: 2022 Jan 13.