Combining T-cell–specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors

Autor: Frank, Annika M., Braun, Angela H., Scheib, Lea, Agarwal, Shiwani, Schneider, Irene C., Fusil, Floriane, Perian, Séverine, Sahin, Ugur, Thalheimer, Frederic B., Verhoeyen, Els, Buchholz, Christian J.

Publikováno v: In Blood Advances 24 November 2020 4(22):5702-5715

Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors.

Autor: Braun AH; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Frank AM; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany., Ho N; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany., Buchholz CJ; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2022 Dec 07; Vol. 28, pp. 90-98. Date of Electronic Publication: 2022 Dec 07 (Print Publication: 2023).