Aporte farmacométrico en el desarrollo de productos biotecnológicos cubanos

Autor: Gledys Reynaldo Fernández, Eduardo M. Fernández-Sánchez, Mayra Ramos Suzarte, Daniel Amaro, Roberto Menéndez, Helena Colom, Víctor Mangas-Sanjuan, Gilberto Castañeda, Jorge Duconge, Braulio Jiménez-Vélez, Niurys de Castro Suárez, Carmen Viada, Joaquín Solazábal, María de los A. Bécquer

Publikováno v: Anales de la Academia de Ciencias de Cuba, Vol 10, Iss 3 (2020)

Introducción. La farmacometría es una disciplina científica vibrante que está conformada por el ciclo de excelencia: integración, innovación e impacto. Objetivo: Evaluar diferentes enfoques farmacométricos en tres productos biotecnológicos cu

Externí odkaz: https://doaj.org/article/2596f3b4e5dc4692a1fa199da1097f0c

Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM2.5, Budesonide, and Cotreated Exposures

Autor: Jarline Encarnación-Medina, Rosa I. Rodríguez-Cotto, Joseph Bloom-Oquendo, Mario G. Ortiz-Martínez, Jorge Duconge, Braulio Jiménez-Vélez

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)

ATP-binding cassette subfamily C (ABCC) genes code for phase III metabolism proteins that translocate xenobiotic (e.g., particulate matter 2.5 (PM2.5)) and drug metabolites outside the cells. IL-6 secretion is related with the activation of the ABCC

Externí odkaz: https://doaj.org/article/1f07ed383a4b4f919fb9387596a05744

From air to heart: Particle pollution (PM2.5) and induced injury on cardioblast cells

Autor: Braulio Jiménez-Vélez, Alexandre Luz de Castro, Enrique Roy Dionisio Calderon, Carla Amorim Neves Gonçalves, Carolina Rosa Gioda, Adriana Gioda, Eduarda Santa-Helena, Tatiana D. Saint’ Pierre

Publikováno v: Atmospheric Pollution Research. 12:152-159

This study evaluated toxicological effects owing to fine particulate matter (PM2.5) exposure in cardioblast cells (H9c2 lineage). The cells were treated with different particulate matter extract solutions for 24 h, F100% (1g of filter containing PM2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e9e52c30b211e7be81da8530972f037
https://doi.org/10.1016/j.apr.2021.03.001

Aqueous particulate matter (PM2.5) from Brazil alters antioxidant profile responses and causes oxidative stress

Autor: Carolina Rosa Gioda, Julia Domingues Ferreiro, Braulio Jiménez-Vélez, Adriana Gioda, Maria Fernanda Cáceres Quijano, Joaquim de Paula Ribeiro, José Maria Monserrat

Publikováno v: Atmospheric Pollution Research. 11:511-519

In vitro assays were used to determine the effects of aqueous fine particulate matter (PM2.5) extracts on different homogenates of rat organs. The PM2.5 collected from two regions (Seropedica and Duque de Caxias) in Rio de Janeiro, Brazil, were used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c66638c42251283a35c27c2a946e5ae
https://doi.org/10.1016/j.apr.2019.11.023

Toxic Metals Depuration Profiles from a Population Adjacent to a Military Target Range (Vieques) and Main Island Puerto Rico

Autor: Braulio Jiménez-Vélez, Hector Jirau-Colón, Víctor Marcial-Vega, Ashley Cosme

Publikováno v: International Journal of Environmental Research and Public Health
Volume 17
Issue 1
International Journal of Environmental Research and Public Health, Vol 17, Iss 1, p 264 (2019)

Background: The island of Vieques (a municipality of Puerto Rico) was used as a military practice range by the US Navy for more than 60 years. Many studies have reported the presence of toxic metals in soil samples taken from Vieques. The bombing ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d899bdeeb1128528179f297d59eaf62
https://doi.org/10.37247/paenvr.1.2020.9