Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Braughler JM"'
Publikováno v:
Biochemical Pharmacology. 45:1477-1482
Oxidative injury was initiated by addition of ferrous ammonium sulfate (FAS) to a suspension of whole rat brain homogenate in Krebs buffer. After FAS addition, tissue vitamin E dropped sharply over a 30-sec interval and then recovered marginally for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ab2c638035b2fb2c7a01eb2e7a5796e
https://doi.org/10.1016/0006-2952(93)90048-2
https://doi.org/10.1016/0006-2952(93)90048-2
Autor:
Eric Jon Jacobsen, K. L. Belonga, VanDoornik Fj, David J. Houser, Braughler Jm, Edward D. Hall, Donald E. Ayer
Publikováno v:
Journal of Medicinal Chemistry. 35:4464-4472
A series of 2-(aminomethyl)chromans was developed as potent inhibitors of iron-dependent lipid peroxidation. Compounds within this class are extremely effective at inhibiting lipid peroxidation with IC50's as low as 0.2 microM. Selected members were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45a7d58fd342d956d75c9f0e2e2362a
https://doi.org/10.1021/jm00101a025
https://doi.org/10.1021/jm00101a025
Publikováno v:
Stroke. 22:361-366
We describe the effects of the 21-aminosteroid tirilazad mesylate (U-74006F) on postischemic lipid peroxidation (depletion of brain vitamin E) and cortical extracellular calcium recovery in gerbils subjected to 3 hours of unilateral carotid artery oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12704a688f026457a817527c3e3798ad
https://doi.org/10.1161/01.str.22.3.361
https://doi.org/10.1161/01.str.22.3.361
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Braughler Jm, Lainer Mj
Publikováno v:
Central Nervous System Trauma. 3:153-161
Using a scoring system designed to assess the severity of neurologic deficit in gerbils during and after temporary unilateral carotid occlusion, the effects of large doses of methylprednisolone sodium succinate (MPSS: Solu-Medrol sterile powder) on e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f4d9bed5af081916db886942e0e709
https://doi.org/10.1089/cns.1986.3.153
https://doi.org/10.1089/cns.1986.3.153
Autor:
Edward D. Hall, Braughler Jm
Publikováno v:
Free Radical Biology and Medicine. 6:289-301
The generation of oxygen radicals and the process of lipid perodixation have become a focus of attention for investigators in the fields of central nervous system (CNS) trauma and stroke (e.g., ischemia). Considering our level of understanding of fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0643f9da37d479d2b4b5e1b4ada5c4
https://doi.org/10.1016/0891-5849(89)90056-7
https://doi.org/10.1016/0891-5849(89)90056-7
Effects of treatment with U-74006F on neurological outcome following experimental spinal cord injury
Autor:
Thomas R. Waters, Edward D. Hall, Braughler Jm, Douglas K. Anderson, John M. McCall, Eugene D. Means
Publikováno v:
Journal of Neurosurgery. 69:562-567
✓ The compound U-74006F is one of a series of 21-aminosteroids that lack glucocorticoid or mineralocorticoid activity. These potent inhibitors of lipid peroxidation have been specifically developed for the acute treatment of central nervous system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12b92fbae03b6d82a1abd2cc2cd9973
https://doi.org/10.3171/jns.1988.69.4.0562
https://doi.org/10.3171/jns.1988.69.4.0562
Autor:
Braughler Jm, Pregenzer Jf
Publikováno v:
Free Radical Biology and Medicine. 7:125-130
The 21-aminosteroids U74006F and U74500A have been examined for their ability to scavenge the lipid peroxyl (LOO.) and phenoxy (PhO.) radicals. Lipid peroxidation was followed by measuring the formation of linoleic acid hydroperoxide (LOOH; 18:200H)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e135925630cdd4d59b38a9eea8931ba3
https://doi.org/10.1016/0891-5849(89)90003-8
https://doi.org/10.1016/0891-5849(89)90003-8
Publikováno v:
Pharmacology Biochemistry and Behavior. 18:477-482
Developmental changes in the behavior and brain biochemistry of rat pups were investigated in rats administered intracisternal injections of 6-hydroxydopamine (6-OHDA) or its vehicle at 5 days of age. Although pups of both groups were equivalent in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbffa3322445a7f603b065fe431ecac
https://doi.org/10.1016/0091-3057(83)90267-8
https://doi.org/10.1016/0091-3057(83)90267-8
Publikováno v:
Stroke. 19:997-1002
U74006F (21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-16 alpha-methylpregna-1,4,9(11)-triene-3,20-dione, monomethane sulfonate) is a novel and potent inhibitor of central nervous system tissue lipid peroxidation that is devoid of classi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e5a1b7c79a9a912f176ae85338aa60
https://doi.org/10.1161/01.str.19.8.997
https://doi.org/10.1161/01.str.19.8.997